Results 101 to 110 of about 1,484,823 (337)

Evaluation of KRAS and NRAS mutations in metastatic colorectal cancer: an 8‐year study of 10 754 patients in Turkey

Molecular Oncology, EarlyView.
This nationwide study evaluated KRAS and NRAS mutations in 10 754 Turkish patients with metastatic colorectal cancer. The results revealed a mutation frequency of 51.1%, with 46.6% having KRAS mutations, 4.5% having NRAS mutations, and 48.5% being wild‐type for both.
Gozde Kavgaci, Izzet Akiva, Yavuz Hakan Ozon, Hakan Berkil, Huseyin Karadayi, Omer Dizdar, Suayib Yalcin   +6 more
wiley   +1 more source

Immunsuppressiva-Medikamentenspiegelmessung – reine Routine? / Immunosuppressant drug monitoring – a routine undertaking? [PDF]

, 2010
The quantitative assessment of immunosuppressant drug levels is still one of the most challenging therapeutic drug monitoring procedures in clinical routine. During the past years, several technical developments matured to useable methods. In addition to
Seger, Christoph, Vogeser, Michael
core   +1 more source

Landscape of BRAF transcript variants in human cancer

Molecular Oncology, EarlyView.
We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda, Danilo Tatoni, Gianluca Mattei, Alberto Magi, Romina D'Aurizio, Laura Poliseno   +5 more
wiley   +1 more source

Antiepileptic Drug Level Monitoring [PDF]

, 2008
Routine monitoring of antiepileptic drug levels does not alter seizure or side effect rates. (Strength of Recommendation [SOR]: B, based on a single randomized controlled trial [RCT] with less than 80 percent follow-up).
Malaty, Wail, Stigleman, Sue
core  

Measuring mental health in criminology research: Lessons from the Drug Use Monitoring in Australia program [PDF]

, 2013
Poor mental health among people in the Australian criminal justice system is increasingly being identified and targeted for remediation. This is evidenced by Australian and international governments establishing specialist services for prisoners with ...
Lubica Forsythe
core   +1 more source

Daily cigarette smoking among inpatients for substance use disorders in France, 2010–2020: Commonalities and specificities across substances

Tobacco Induced Diseases
Introduction This study aims to estimate the prevalence and factors associated with cigarette smoking among patients in treatment for substance use disorders (SUD) in France.
Eric Janssen, Mike Vuolo, Guillaume Airagnes   +2 more
doaj   +1 more source

Study of adverse drug reactions of atypical antipsychotic drugs in the department of psychiatry in a tertiary care hospital of Assam

Open Journal of Psychiatry and Allied Sciences, 2017
Objective: To monitor the adverse drug reactions (ADRs) of atypical antipsychotic drugs in the outpatient department (OPD) of psychiatry in Silchar Medical College and Hospital (SMCH) of Assam, and also to find out the causality and severity of ADRs ...
Pinaki Chakravarty, Parthajyoti Neog, Babul Dewan   +2 more
doaj   +1 more source

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

Molecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine, Sterenn Guillemot, Louis‐Bastien Weiswald, Romane Florent, Edwige Abeilard, Florence Giffard, Emilie Brotin, Mélanie Briand, Enora Dolivet, Laurent Poulain, Marie Villedieu   +10 more
wiley   +1 more source

Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer

Molecular Oncology, EarlyView.
Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte, Osheen Sharma, Laura Leuenberger, Emelie Wallin, Josefin Fernebro, Päivi Östling, Rebecka Bergström, Johan Lindberg, Ulrika Joneborg, Olli Kallioniemi, Brinton Seashore‐Ludlow   +10 more
wiley   +1 more source

Safety of medication use in primary care [PDF]

, 2015
© 2014 Royal Pharmaceutical Society.BACKGROUND: Medication errors are one of the leading causes of harmin health care. Review and analysis of errors have often emphasized their preventable nature and potential for reoccurrence.
Abramson, Abramson, Adubofour, Ahmad, Al Khaja, Al Khaja, Alldred, Alldred, Aronson, Aronson, Ashcroft, Avery, Avery, Avery, Barber, Bayoumi, Berner, Bernstein, Beso, Boockvar, Boockvar, Booij, Braund, Bregnhoj, Britt, Brown, Buurma, Campbell, Carruthers, Chen, Chua, Coleman, Dallenbach, Dean, Dean, Dean, Dean Franklin, Dean Franklin, Department of Health, Department of Health, Department of Health, Devine, Dhabali, Eslami, Field, Fischer, Flynn, Gagne, Gandhi, Gandhi, Gandhi, Garfield, Ghaleb, Ginzburg, Glassman, Green, Gurwitz, Hazlet, Howard, Hume, Humphries, Hämmerlein, Janice O. Olaniyan, Kaushal, Kaushal, Kennedy, Khoja, Knudsen, Knudsen, Kohn, Kuo, Lafata, Lasser, Leape, Lemer, Lewis, Lisby, Lopez-Picazo, Lynskey, Maisoon Ghaleb, Martínez Sánchez, Marwaha, Miller, Moniz, Nanji, Nemeth, Norden-Hagg, Palen, Paul Robinson, Pirmohamed, Raebel, Reason, Royal, Runciman, Sarvadikar, Sayers, Shah, Singh, Soraya Dhillon, Sorensen, Stefanovic, Sweidan, Szczepura, Tam, Tamblyn, Teinilä, Thomsen, Varkey, Vincent, Warholak, Wetzels, Wild, Wong, World Health Organisation   +113 more
core   +1 more source