Results 111 to 120 of about 1,599,561 (306)

Daily cigarette smoking among inpatients for substance use disorders in France, 2010–2020: Commonalities and specificities across substances

Tobacco Induced Diseases
Introduction This study aims to estimate the prevalence and factors associated with cigarette smoking among patients in treatment for substance use disorders (SUD) in France.
Eric Janssen, Mike Vuolo, Guillaume Airagnes   +2 more
doaj   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Clinical proteomics for precision medicine: the bladder cancer case [PDF]

, 2017
Precision medicine can improve patient management by guiding therapeutic decision based on molecular characteristics. The concept has been extensively addressed through the application of –omics based approaches.
Frantzi, Maria, Latosinska, Agnieszka, Merseburger, Axel S., Mischak, Harald, Vlahou, Antonia   +4 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The Use of Self-Report and Drugs Tests in the Measurement of Illicit Drug Consumpiton [PDF]

We use data from the New England and Wales Arrestee Drug Abuse Monitoring (NEW-ADAM) programme to assess the validity of self-report measures of illicit drug use and to evaluate the use of alternative drug testing strategies within survey enquiries.
Stephen Pudney, Ziggy MacDonald
core  

Adherence to antiretroviral therapy assessed by drug level monitoring and self-report in cameroon [PDF]

, 2008
OBJECTIVES: To compare adherence to antiretroviral therapy using drug level monitoring and self-report and to explore the relation between these 2 methods and viral load measurements.
Alexandra Calmy, Bell, Berg, Chaix, Charles Kouanfack, Chesney, Christian Laurent, Claudine Essomba, Eitel Mpoudi-Ngolé, Eric Delaporte, Gill, Gilles Peytavin, Laniece, Laura Ciaffi, Laurent, Laurent, Maguy Ngolle, Mannheimer, Mills, Murphy, Nachega, Orrell, Osterberg, Oyugi, Sethi, Sinata Koulla-Shiro, Van Heeswijk, van Oosterhout, Wainberg, Yvette Mawamba Nkene   +29 more
core   +3 more sources

Predictors of concurrent heroin use among patients on opioid maintenance treatment in France: a multilevel study over 11 years

Harm Reduction Journal
Background Consistent reports from health professionals suggest that heroin is commonly used by patients undergoing opioid maintenance treatment (OMT) in France, potentially jeopardizing their recovery process.
Eric Janssen, Mike Vuolo, Stanislas Spilka, Guillaume Airagnes   +3 more
doaj   +1 more source

Therapeutic drug monitoring of cytotoxic drugs [PDF]

British Journal of Clinical Pharmacology, 2001
Therapeutic drug monitoring is not routinely used for cytotoxic agents. There are several reasons, but one major drawback is the lack of established therapeutic concentration ranges. Combination chemotherapy makes the establishment of therapeutic ranges for individual drugs difficult, the concentration‐effect relationship for a single drug may not be ...
openaire   +3 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Initial Development toward Non-Invasive Drug Monitoring via Untargeted Mass Spectrometric Analysis of Human Skin. [PDF]

, 2019
Drug monitoring is crucial for providing accurate and effective care; however, current methods (e.g., blood draws) are inconvenient and unpleasant. We aim to develop a non-invasive method for the detection and monitoring of drugs via human skin.
Bouslimani, Amina, da Silva, Ricardo R, Del Rosario, Krizia K, Dorrestein, Pieter C, Elijah, Emmanuel O, Ernst, Madeleine, Jarmusch, Alan K, Tsunoda, Shirley M, Vargas, Fernando, Wang, Mingxun   +9 more
core   +1 more source