Results 131 to 140 of about 9,044,537 (408)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Polymorphisms in Plasmodium falciparum chloroquine resistance transporter and multidrug resistance 1 genes: parasite risk factors that affect treatment outcomes for P. falciparum malaria after artemether-lumefantrine and artesunate-amodiaquine. [PDF]

, 2014
Adequate clinical and parasitologic cure by artemisinin combination therapies relies on the artemisinin component and the partner drug. Polymorphisms in the Plasmodium falciparum chloroquine resistance transporter (pfcrt) and P.
Adam, Ishag, Ademowo, George, Arze, Cesar, Asaq Molecular Marker Study Group, Baliraine, Frederick N, Berens-Riha, Nicole, Björkman, Anders, Borrmann, Steffen, Checchi, Francesco, Dahal, Prabin, Davis, Timothy ME, Desai, Meghna, Dhorda, Mehul, Djimdé, Abdoulaye A, Dorsey, Grant, El-Sayed, Badria B, Eshetu, Teferi, Eyase, Frederick, Falade, Catherine, Faucher, Jean-François, Fröberg, Gabrielle, Gadalla, Nahla B, Grivoyannis, Anastasia, Guérin, Philippe, Hamour, Sally, Houzé, Sandrine, Johnson, Jacob, Kamugisha, Erasmus, Kariuki, Simon, Kiechel, Jean-René, Kironde, Fred, Kofoed, Poul-Erik, LeBras, Jacques, Malmberg, Maja, Moriera, Clarissa, Mwai, Leah, Mårtensson, Andreas, Ménard, Didier, Ngasala, Billy, Nosten, Francois, Nsanzabana, Christian, Nsobya, Samuel L, Nzila, Alexis, Oguike, Mary, Ogutu, Bernhards, Otienoburu, Sabina Dahlström, Ouédraogo, Jean-Bosco, Piola, Patrice, Plowe, Christopher V, Price, Ric N, Rombo, Lars, Rosenthal, Philip J, Schramm, Birgit, Sibley, Carol Hopkins, Somé, A Fabrice, Stepniewska, Kasia, Sutherland, Colin J, Thwing, Julie, Ursing, Johan, Venkatesan, Meera, Wong, Rina PM, Zeynudin, Ahmed, Zongo, Issaka   +62 more
core   +4 more sources

Therapeutic Drug Monitoring of Antiepileptic Drugs

Journal of Nepal Medical Association, 2008
Commonly used conventional antiepileptic drugs for pharmacotherapy in epilepsy are phenytoin, carbamazepine and valproic acid. These drugs have complex pharmacokinetic properties leading to fluctuation in their plasma level at given same therapeutic dose. The present study was done to monitor their plasma levels.
Geeta Shakya, S Malla, R Shrestha, K N Shakya   +3 more
openaire   +4 more sources

Therapeutic Drug Monitoring in Oncology: International Association of Therapeutic Drug Monitoring and Clinical Toxicology Recommendations for 5‐Fluorouracil Therapy

Clinical pharmacology and therapy, 2018
5‐Fluorouracil (5‐FU) is dosed by body surface area, a practice unable to reduce the interindividual variability in exposure. Endorsed by the International Association of Therapeutic Drug Monitoring and Clinical Toxicology (IATDMCT), we evaluated ...
J. Beumer, E. Chu, C. Allegra, Y. Tanigawara, G. Milano, R. Diasio, Tae Won Kim, R. Mathijssen, Li Zhang, D. Arnold, K. Muneoka, N. Boku, M. Joerger   +12 more
semanticscholar   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Daily cigarette smoking among inpatients for substance use disorders in France, 2010–2020: Commonalities and specificities across substances

Tobacco Induced Diseases
Introduction This study aims to estimate the prevalence and factors associated with cigarette smoking among patients in treatment for substance use disorders (SUD) in France.
Eric Janssen, Mike Vuolo, Guillaume Airagnes   +2 more
doaj   +1 more source

Study of adverse drug reactions of atypical antipsychotic drugs in the department of psychiatry in a tertiary care hospital of Assam

Open Journal of Psychiatry and Allied Sciences, 2017
Objective: To monitor the adverse drug reactions (ADRs) of atypical antipsychotic drugs in the outpatient department (OPD) of psychiatry in Silchar Medical College and Hospital (SMCH) of Assam, and also to find out the causality and severity of ADRs ...
Pinaki Chakravarty, Parthajyoti Neog, Babul Dewan   +2 more
doaj   +1 more source

A dynamic Bayesian nonlinear mixed-effects model of HIV response incorporating medication adherence, drug resistance and covariates

, 2011
HIV dynamic studies have contributed significantly to the understanding of HIV pathogenesis and antiviral treatment strategies for AIDS patients. Establishing the relationship of virologic responses with clinical factors and covariates during long-term ...
Acosta, Edward P., Holden-Wiltse, Jeanne, Huang, Yangxin, Wu, Hulin   +3 more
core   +1 more source

The role of drug resistance in poor viral suppression in rural South Africa: findings from a population-based study. [PDF]

, 2020
BACKGROUND:Understanding factors driving virological failure, including the contribution of HIV drug resistance mutations (DRM), is critical to ensuring HIV treatment remains effective.
Barnhart, Scott, Gilmore, Hailey J, Grignon, Jessica S, Hunt, Gillian, Liegler, Teri, Lippman, Sheri A, Mooney, Alyssa C, Prach, Lisa M, Puren, Adrian, Truong, Hong-Ha M   +9 more
core  

Therapeutic Drug Monitoring of Antibody Drugs

Biological and Pharmaceutical Bulletin, 2022
In recent years, many antibody drugs that play an important role in the pharmacotherapy of several diseases have been developed. Antibody drugs exhibit immunogenicity in vivo leading to the development of antibodies against the antibody drug (anti-drug antibody). Nonetheless, other factors also affect the pharmacokinetics of antibody drugs.
openaire   +2 more sources