Results 131 to 140 of about 8,578,730 (368)

Recreational Use of Nitrous Oxide – a Growing Concern in Europe

Emerging Trends in Drugs, Addictions, and Health
Introduction: Nitrous oxide, commonly known as laughing gas, is used medically as an analgesic and anaesthetic. It has been used recreationally for its brief euphoric effects for over 200 years, however, in the last decade, there has been a large ...
J. De Morais, L. Van Aerts, M. Evans-Brown, A. Gallegos, R. Christie, R. Jorge, T. Néfau, G. Planchuelo, R. Sedefov, C. Victorri-Vigneau, R. Povilanskiene, K. Grasaasen, D.F.t. Palmqvis, D. Mongan, K. Killeen, A.O. Duarte, A.S. Santos   +16 more
doaj  

The efficacy and safety of novel antiepileptic drugs in treatment of epilepsy of patients with brain tumors

Frontiers in Neurology
ObjectiveThis meta-analysis aimed to assess the effectiveness and safety of novel antiepileptic drugs (AEDs) in treating epilepsy in patients with brain tumors (BTRE).MethodsA search was conducted on PubMed, EMBASE, Web of Science, and the Cochrane ...
Weiwei Zhai, Weiwei Zhai, Qiaoling Yu, Qiaoling Yu, Huizhen Wu, Huizhen Wu   +5 more
doaj   +1 more source

GNTeam at 2018 n2c2: Feature-augmented BiLSTM-CRF for drug-related entity recognition in hospital discharge summaries [PDF]

arXiv, 2019
Monitoring the administration of drugs and adverse drug reactions are key parts of pharmacovigilance. In this paper, we explore the extraction of drug mentions and drug-related information (reason for taking a drug, route, frequency, dosage, strength, form, duration, and adverse events) from hospital discharge summaries through deep learning that ...
arxiv  

Etoposide‐induced cancer cell death: roles of mitochondrial VDAC1 and calpain, and resistance mechanisms

Molecular Oncology, EarlyView.
The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita, Varda Shoshan‐Barmatz   +1 more
wiley   +1 more source

Seasonal Use of Marijuana and Cocaine by Arrestees in Anchorage, Alaska [PDF]

, 2005
Previously presented at the Western Society of Criminology, Honolulu, HI, Feb 2005.This paper explores the relation between season (fall, winter, spring and summer) and drug use among arrestees.
Langworthy, Robert H., McKelvie, Alan R.
core  

Therapeutic Drug Monitoring of Oral Anticancer Drugs: The Dutch Pharmacology Oncology Group-Therapeutic Drug Monitoring Protocol for a Prospective Study.

Therapeutic Drug Monitoring, 2019
BACKGROUND Oral anticancer drugs show a high interpatient variability in pharmacokinetics (PK), leading to large differences in drug exposure. For many of these drugs, exposure has been linked to efficacy and toxicity. Despite this knowledge, these drugs
S. Groenland, Ruben A. G. van Eerden, R. Verheijen, S. Koolen, D. Moes, I. Desar, A. Reyners, H. Gelderblom, N. V. van Erp, R. Mathijssen, A. Huitema, N. Steeghs   +11 more
semanticscholar   +1 more source

Respiratory complex I‐mediated NAD+ regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21Cip1 expression by SIRT3 and SIRT7

Molecular Oncology, EarlyView.
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi, Kazunori Mori, Hidetsugu Nakagawa, Momoko Uchida, Fumihiro Ishikawa, Motoko Shibanuma   +5 more
wiley   +1 more source

Era of direct acting anti-viral agents for the treatment of hepatitis C. [PDF]

, 2018
Hepatitis C infection is universal and the most common indication of liver transplantation in the United States. The period of less effective interferon therapy with intolerable side effects has gone.
Ahmed, Monjur
core   +1 more source

An on-line solid phase extraction procedure for the routine quantification of caspofungin by liquid chromatography-tandem mass spectrometry [PDF]

, 2012
Background: Extensive sets of data are required to investigate the potential use of a therapeutic drug monitoring with individualization of dosage of the antimycotic compound caspofungin.
Kirchhoff, Fabian, Maier, Barbara, Ostermann, Helmut, Rieger, Christina, Spoehrer, Ute, Vogeser, Michael   +5 more
core   +1 more source

Predictors of concurrent heroin use among patients on opioid maintenance treatment in France: a multilevel study over 11 years

Harm Reduction Journal
Background Consistent reports from health professionals suggest that heroin is commonly used by patients undergoing opioid maintenance treatment (OMT) in France, potentially jeopardizing their recovery process.
Eric Janssen, Mike Vuolo, Stanislas Spilka, Guillaume Airagnes   +3 more
doaj   +1 more source