Results 141 to 150 of about 9,044,537 (408)
Association Between Prescription Drug Monitoring Programs and Nonfatal and Fatal Drug Overdoses
Annals of Internal Medicine, 2018 The overuse of prescription opioids during the past 2 decades has evolved into a major public health issue in the United States. Opioid prescribing increased 350% between 1999 and 2015, from 180 to 640 morphine milligram equivalents per capita (1), with ...
David S. Fink +10 more
semanticscholar +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
The Use of Self-Report and Drugs Tests in the Measurement of Illicit Drug Consumpiton [PDF]
We use data from the New England and Wales Arrestee Drug Abuse Monitoring (NEW-ADAM) programme to assess the validity of self-report measures of illicit drug use and to evaluate the use of alternative drug testing strategies within survey enquiries.
Stephen Pudney, Ziggy MacDonald
core
Ictal kissing: occurrence and etiology. [PDF]
, 2016 Ictal kissing is a rare semiological manifestation in patients with epilepsy. We tried to estimate its occurrence and characterize the underlying etiology.
Asadi-Pooya, Ali Akbar +1 more
core +2 more sources
A systematic review of the effect of therapeutic drug monitoring on patient health outcomes during treatment with penicillins [PDF]
, 2022 Timothy Luxton +4 more
openalex +1 more source
Practical Recommendations for Therapeutic Drug Monitoring of Kinase Inhibitors in Oncology
Clinical pharmacology and therapy, 2017 Despite the fact that pharmacokinetic exposure of kinase inhibitors (KIs) is highly variable and clear relationships exist between exposure and treatment outcomes, fixed dosing is still standard practice.
R. Verheijen +5 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Harm Reduction JournalBackground Consistent reports from health professionals suggest that heroin is commonly used by patients undergoing opioid maintenance treatment (OMT) in France, potentially jeopardizing their recovery process.
Eric Janssen +3 more
doaj +1 more source
Frontiers in NeurologyObjectiveThis meta-analysis aimed to assess the effectiveness and safety of novel antiepileptic drugs (AEDs) in treating epilepsy in patients with brain tumors (BTRE).MethodsA search was conducted on PubMed, EMBASE, Web of Science, and the Cochrane ...
Weiwei Zhai +5 more
doaj +1 more source
Challenges and Opportunities for the Implementation of Virological Testing in resource-limited settings [PDF]
, 2012 Though the advantages of routine virological monitoring for patients on anti-retroviral therapy have been established, cost and complexity limit its full implementation.
Bartlett +22 more
core +3 more sources