Results 251 to 260 of about 873,917 (301)

Therapeutic drug monitoring

Acta Neuropsychiatrica, 1999
SUMMARYThe cytochrome P450 iso-enzyme system plays a key role in the biotransformation of many drugs, including psychotropics. Its activity is determined by both genetic and environmental factors. The most important iso-enzymes for psychiatry in general are P450 IID6, 3A4 and 1A2.
J B, Noten, W M, Verhoeven, S, Tuinier, D, Touw   +3 more
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Antiarrhythmic Drug Monitoring

Clinics in Laboratory Medicine, 1981
The classification of antiarrhythmic agents by mechanism of action aids the clinician in selecting appropriate antiarrhythmic drug therapy. The pharmacokinetics, the side effects, and the interpretation of serum levels of quinidine, procainamide, disopyramide, lidocaine, and other agents are discussed.
J H, Howanitz, P J, Howanitz
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Free Drug Monitoring

Clinics in Laboratory Medicine, 1987
The principles, technique of measurement, and clinical significance of free drugs are reviewed. Albumin, alpha-1-acid glycoprotein, and lipoprotein are the main drug-binding proteins in blood. Variations of the concentrations of these proteins owing to disease would result in changes in the free drug levels.
S, Chan, B, Gerson
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Antineoplastic Drug Monitoring

Clinics in Laboratory Medicine, 1987
The ability to monitor biologically significant levels of antineoplastic drugs in patients' plasma is rapidly expanding. The expanded application of therapeutic drug monitoring to the clinical practice of oncology will require a better understanding of the relationship between drug levels, toxicity, and therapeutic benefit in particular patient ...
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Monitoring of Drug-Drug and Drug-Food Interactions

American Journal of Health-System Pharmacy, 1988
A program for detecting and preventing potentially serious drug-drug and drug-food interactions is described. Two clinical pharmacists developed drug interaction alert (DIA) cards for each potential interaction to be monitored. The cards contain information about the proposed mechanism and potential result of the interaction, as well as information ...
S M, Garabedian-Ruffalo, M, Syrja-Farber, P M, Lanius, A, Plucinski   +3 more
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Drug level monitoring of antiasthmatic drugs

Journal of Chromatography B: Biomedical Sciences and Applications, 1985
In general assays pertaining to drug level monitoring (DLM) of antiasthmatic agents (except theophylline), published during the period 1978-1983, used mostly high-performance liquid chromatographic (HPLC) methodology (approximately 45%) with mass spectrometric (MS) based assays in second place (approximately 30%) followed by immunochemical techniques ...
N, Kucharczyk, F H, Segelman
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Drug level monitoring: cardiovascular drugs

Journal of Chromatography B: Biomedical Sciences and Applications, 1985
Methods for the determination of cardiovascular drugs in blood and plasma are critically reviewed with emphasis on gas and liquid chromatographic techniques. The importance of the various procedures is discussed, in particular sample work-up where the conditions for isolation and derivatization of the compounds are decisive for the accuracy and ...
M, Ahnoff, M, Ervik, P O, Lagerström, B A, Persson, J, Vessman   +4 more
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Therapeutic Drug Monitoring of Antiarrhythmic Drugs

Clinical Pharmacokinetics, 2003
Most antiarrhythmic drugs fulfil the formal requirements for rational use of therapeutic drug monitoring, as they show highly variable plasma concentration profiles at a given dose and a direct concentration-effect relationship. Therapeutic ranges for antiarrhythmic drugs are, however, often very poorly defined.
Gesche, Jürgens, Niels A, Graudal, Jens P, Kampmann   +2 more
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