Advanced Biology, EarlyView.The prodrug strategy used in this study offers new promise for cancer metabolism‐based therapies. JHU083, a prodrug that, when cleaved by protease in the tumor microenvironment, yields the glutamine antagonist DON. JHU083 inhibits tumor growth by targeting glutamine‐addicted cancer cells and suppressing glutamine‐dependent M2 macrophages, leading to a ...
Tianhe Li +10 more
wiley +1 more source
Unexpected Falsely High Vancomycin Concentrations in a Patient with Endocarditis During Routine Therapeutic Drug Monitoring. [PDF]
Eur J Case Rep Intern MedGalán-Caballero L +6 more
europepmc +1 more source
Intracavernosal Pressure Monitoring in Mice: Responses to Electrical Stimulation of the Cavernous Nerve and to Intracavernosal Drug Administration [PDF]
, 2000 Sena F. Sezen, Arthur L. Burnett
openalex +1 more source
Advanced Biology, EarlyView.This study develops a tissue‐engineered model of the atherosclerotic cap using human mesenchymal stromal cells (MSCs). After 2 weeks of culture to produce a collagenous matrix, a mineralizing medium induces microcalcifications over 4 weeks. These constructs, imaged with second harmonic generation microscopy, lead to reduced ultimate stress at rupture ...
Imke L. Jansen +4 more
wiley +1 more source
Therapeutic drug monitoring of vancomycin: A retrospective cross-sectional study of blood draw timing and clinical outcomes. [PDF]
Medicine (Baltimore)Alrasheed MA +9 more
europepmc +1 more source
A Calorimetric Study on Diflunisal Release from Poly(Lactide-co-Glycolide) Microspheres by Monitoring the Drug Effect on Dipalmitoylphosphatidylcholine Liposomes: Temperature and Drug Loading Influence [PDF]
, 2000 Francesco Castelli +3 more
openalex +1 more source
Advanced Biology, EarlyView.The glomerular filtration barrier (GFB) is the first step of blood filtration by the kidneys. The concerning increase of kidney diseases makes the development of new models essential. In this context, microphysiological glomerular filtration barriers focus on closely reproducing the physiological architecture of the in vivo GFB: podocytes, glomerular ...
Manon Miran +5 more
wiley +1 more source
Association of early therapeutic drug monitoring of adalimumab with biologic remission and drug survival in Crohn's Disease. [PDF]
Therap Adv GastroenterolRueda García JL +10 more
europepmc +1 more source
Identifying hospital admissions due to adverse drug events using a computer‐based monitor [PDF]
, 2001 Ashish K. Jha +4 more
openalex +1 more source
Advanced Biology, EarlyView.A detailed workflow for recombinant GALC production and characterization is presented to support enzyme replacement therapy for Krabbe disease. In vitro assays demonstrate that physiological GALC doses restore enzymatic activity and autophagic flux without affecting cell viability, whereas higher doses impair autophagy and reduce viability.
Ambra Del Grosso +5 more
wiley +1 more source