Results 71 to 80 of about 8,578,730 (368)

Electrochemical Aptamer-based Sensors for Improved Therapeutic Drug Monitoring and High-Precision, Feedback-controlled Drug Delivery.

ACS Sensors, 2019
The Electrochemical Aptamer-Based (E-AB) sensing platform appears a convenient (rapid, single-step, calibration-free), modular approach to measure concentrations of specific molecules (irrespective of their chemical reactivity) directly in blood and even
Philippe Dauphin-Ducharme, Kyungae Yang, N. Arroyo‐Currás, Kyle L Ploense, Yameng Zhang, Julian Gerson, M. Kurnik, T. Kippin, M. Stojanović, K. Plaxco   +9 more
semanticscholar   +1 more source

Social context prevents heat hormetic effects against mutagens during fish development

FEBS Letters, EarlyView.
This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere, Claudio Silva De Freitas, Adam Bates, Kenneth B. Storey, Pedro Beltran‐Alvarez, Katharina C. Wollenberg Valero   +5 more
wiley   +1 more source

Timeliness of Clinic Attendance is a good predictor of Virological Response and Resistance to Antiretroviral drugs in HIV-infected patients [PDF]

, 2012
Ensuring long-term adherence to therapy is essential for the success of HIV treatment. As access to viral load monitoring and genotyping is poor in resource-limited settings, a simple tool to monitor adherence is needed.
A Ammassari, A Calmy, AD Harries, AM Abaasa, AT Brennan, Cecilia Ferreyra, D Ross-Degnan, DR Bangsberg, EJ Mills, EJ Mills, Elisabeth Szumilin, GP Bisson, K Bhaskaran, L Ferradini, L Ferradini, LC Ivers, Loretxu Pinoges, M Bastard, M Pujades-Rodriguez, Mar Pujades-Rodriguez, Mathieu Bastard, Matthew P. Fox, N Ford, RW Shafer, Suna Balkan, TF Liu, TJ Cole, VD Lima, Z El-Khatib   +28 more
core   +4 more sources

A lab-on-a-disc platform enables serial monitoring of individual CTCs associated with tumor progression during EGFR-targeted therapy for patients with NSCLC [PDF]

, 2020
Rationale: Unlike traditional biopsy, liquid biopsy, which is a largely non-invasive diagnostic and monitoring tool, can be performed more frequently to better track tumors and mutations over time and to validate the efficiency of a cancer treatment ...
Cho, Yoon-Kyoung, Jeong, Hyoung-oh, Kim, Gwang Ha, Kim, Mi-Hyun, Lee, Kyusang, Lee, Semin, Lim, Minji, Lowe, Alarice C., Park, Hee Chul, Park, Juhee   +9 more
core   +1 more source

Mass Fragmentation Characteristics of t-Boc Substituted Drug Precursors

Zhipu Xuebao
To circumvent the supervision of law, illicit manufacturers turn to produce drug related precursors. Among them, tert-butoxycarbonyl (t-Boc) substituted drug precursors are the most common type recently.
Cui-mei LIU, Xue-yan LIU, Zhen-dong HUA, Hao TANG, Yu DU, Wei JIA   +5 more
doaj   +1 more source

BioDEX: Large-Scale Biomedical Adverse Drug Event Extraction for Real-World Pharmacovigilance [PDF]

arXiv, 2023
Timely and accurate extraction of Adverse Drug Events (ADE) from biomedical literature is paramount for public safety, but involves slow and costly manual labor. We set out to improve drug safety monitoring (pharmacovigilance, PV) through the use of Natural Language Processing (NLP).
arxiv  

Spot‐14 and its paralog Spot‐14R regulate expression of metabolic and thermogenic pathway genes in murine brown and beige adipocytes

FEBS Letters, EarlyView.
Spot‐14 and Spot‐14R play distinct roles in regulating metabolism in brown and beige adipocytes. While both influence lipid and glucose pathways, Spot‐14 uniquely controls thermogenic gene expression. This dual regulation balances energy storage and heat production, highlighting potential therapeutic targets for obesity and metabolic disorders. Spot 14
Lidia Itzel Castro‐Rodríguez, Cristina Velez‐delValle, Claudia Patricia Hernández‐Mosqueira, Walid Kuri‐Harcuch   +3 more
wiley   +1 more source

Quantifying Isoniazid Levels in Small Hair Samples: A Novel Method for Assessing Adherence during the Treatment of Latent and Active Tuberculosis. [PDF]

, 2016
BackgroundTuberculosis (TB) is the leading cause of death from an infectious pathogen worldwide and the most prevalent opportunistic infection in people living with HIV.
Bacchetti, Peter, Chin, Aaron T, Gandhi, Monica, Gerona, Roy, Koss, Catherine A, Metcalfe, John, Wen, Anita   +6 more
core   +1 more source

Quantitative Surveys in Hard-to-Reach Populations: The Experience of the ‘Observatoire Français Des Drogues Et Des Toxicomanies’

Methodological Innovations, 2010
This article presents a research device (drawn up by the ‘Observatoire français des drogues et des toxicomanies' or OFDT) for exploring drug consumption practices among ‘hard-to-reach users’.
Agnès Cadet-Taïrou, Catherine Reynaud-Maurupt, Jean-Michel Costes, Christophe Palle   +3 more
doaj   +1 more source

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source