Results 71 to 80 of about 873,917 (301)
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Personalized therapy for oral anticancer drugs: an integrated approach based on therapeutic drug monitoring and pharmacogenetics for sunitinib and imatinib. [PDF]
, 2022 openOral anticancer drugs have substantially enhanced treatment options for patients with cancer: from the use of cytotoxic drugs and non-specific chemotherapy to chronic oral treatment with targeted molecular therapies.
ZINATO, MADDALENA
core
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Determination of α-hydroxy acids in cosmetics by UHPLC-MS/MS
Shanghai yufang yixueObjectiveTo establish a UHPLC-MS/MS quantitative method for the determination of glucuronic acid， tartaric acid， glycolic acid， malic acid， lactic acid， citric acid， DL-2-hydroxybutyric acid sodium， mandelic acid， benzilic acid， hydroxycaprylic acid ...
RU Ge +5 more
doaj +1 more source
Methodological Innovations, 2010 This article presents a research device (drawn up by the ‘Observatoire français des drogues et des toxicomanies' or OFDT) for exploring drug consumption practices among ‘hard-to-reach users’.
Agnès Cadet-Taïrou +3 more
doaj +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
PharmaceuticsBackground: This study aimed to evaluate different Bayesian algorithms and the first-order pharmacokinetics (PK) equation approach for forecasting vancomycin concentrations in critically ill pediatric patients and to identify influencing factors. Methods:
Ha T. Pham +11 more
doaj +1 more source
Therapeutic Drug Monitoring of Antibody Drugs
Biological and Pharmaceutical Bulletin, 2022 In recent years, many antibody drugs that play an important role in the pharmacotherapy of several diseases have been developed. Antibody drugs exhibit immunogenicity in vivo leading to the development of antibodies against the antibody drug (anti-drug antibody). Nonetheless, other factors also affect the pharmacokinetics of antibody drugs.
openaire +2 more sources
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Improving reporting of adverse drug reactions: Systematic review. [PDF]
, 2009 BACKGROUND: Adverse drug reactions (ADRs) are a significant cause of morbidity and mortality, with many being identified post-marketing. Improvement in current ADR reporting, including utility of underused or innovative methods, is crucial to improve ...
Molokhia, Mariam +8 more
core +1 more source