Results 101 to 110 of about 92,382 (306)
Investigating the Cytoskeleton of DRGs Using Cryo‐Electron Microscopy and Deep Learning
Cytoskeleton, EarlyView.ABSTRACT We describe a method for determining the ultrastructural organization of axons and varicosities of cultured dorsal root ganglion (DRG) neurons using cryogenic electron microscopy (cryo‐EM). Cryo‐EM reveals the dimensions, proximity, and overall organization of biological specimens in a near‐native state, avoiding artifacts of fixation and ...
M. Neal Waxham +3 more
wiley +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Clinical translation of novel therapies can be hindered by heterogeneity‐driven sample size inflation in late‐stage trials. In acetaminophen‐induced liver injury (APAP DILI), many patients recover spontaneously, diluting investigational drug efficacy signals.
Chris Humphries +8 more
wiley +1 more source
Former prisoners are most at risk from drug overdose after jail release or cash windfall. [PDF]
Former prisoners were most at risk from a drug overdose following a cash windfall, or immediately after leaving rehab or jail, a campaign to combat drug deaths said. An information sheet for vulnerable users said people also needed to be aware of “common
Foxe, Ken
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Clinical Pharmacology &Therapeutics, EarlyView.Personalized dosing is particularly important for drugs with narrow therapeutic indices in geriatric patients, who exhibit substantial physiological variability and limited pharmacokinetic (PK) evidence to guide individualized dose selection. Valproic acid (VPA) is an effective treatment option for bipolar disorder in older adults, yet dosing largely ...
Yoo Jin Jang +2 more
wiley +1 more source
The effects of the decriminalization of drug use in Portugal [PDF]
, 2007 In 2004, the Beckley Foundation reported on the legal changes that took place in Portugal in 2001 (Allen, Trace & Klein 2004). This report aims to provide an updated overview of the effects of these changes, using data from the evaluations that have been
Stevens, Alex, Hughes, Caitlin Elizabeth
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Describing at risk populations and emerging trends in opioid and stimulant co-occurrence in drug use, nonfatal overdoses, and fatal overdoses in the United States [PDF]
Background Drug overdose is one of the leading causes of injury death in the United States. Polysubstance use is the ingestion/injection of more than one substance at the same time, either intentionally or unknowingly, by the person using drugs.
Smith, Herschel W
core +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Antibody–drug conjugates (ADCs) combine the specificity of an antibody with the potency of a cytotoxic drug. Thirteen ADCs, utilizing seven unique cytotoxic payloads and targeting 11 distinct antigens, are currently approved by the US Food and Drug Administration as of June 2025, representing a rapidly growing and highly promising class of anticancer ...
Sijie Lu +6 more
wiley +1 more source
Drug Overdose Death Rates in America Are Now Higher in Rural Areas Than Urban Areas [PDF]
Learn more about how to prevent drug overdose.www.cdc.gov/drugoverdoseMMWR-Rural-Health-Series-drug-overdose-medium ...
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Strengthening Pharmacovigilance Reporting for Withdrawal Reactions to Support Deprescribing
Clinical Pharmacology &Therapeutics, EarlyView.Pharmacovigilance plays a crucial role in post‐marketing surveillance of medicines and relies on the spontaneous reporting of adverse drug reactions (ADRs). Discontinuation of a drug can cause clinically relevant signs and symptoms, including withdrawal reactions; however, this subset of ADRs is not fully accommodated in current pharmacovigilance ...
Zakir Khan, Frank Moriarty
wiley +1 more source
Who is Overdosing? An Updated Picture of Overdose Deaths From 2008 to 2015
Health Services Research & Managerial Epidemiology, 2017 Purpose: To determine the role of opioids in drug overdose deaths in Allen County, Indiana between January 1, 2008, and December 31, 2015. Methods: File review of 418 overdose deaths was performed using Indiana State Department of Health death ...
Gregory Eigner +6 more
doaj +1 more source