Results 101 to 110 of about 92,110 (306)

Applying machine learning to pharmacovigilance data: A proof‐of‐concept study

British Journal of Clinical Pharmacology, EarlyView.
Aim Machine learning (ML) applications in pharmacovigilance remain limited and underexplored. Using data from the French National pharmacovigilance database (FNPV), this proof‐of‐concept study aimed to assess the feasibility of using a ML algorithm—eXtreme Gradient Boosting (XGBoost)—combined with SHapley Additive exPlanations (SHAP) analysis, to ...
Romain Barus, Pauline Schiro, Jean‐Luc Faillie, Romane Freppel, Johana Béné, Claire de Canecaude, François Montastruc   +6 more
wiley   +1 more source

Tunable amylopectin graft copolymers for flocculating and dewatering iron ore tailings

The Canadian Journal of Chemical Engineering, EarlyView.
Abstract Polyacrylamide (PAM), the standard flocculant for mining tailings, often produces turbid supernatants and poorly dewatered sediments, limiting water reuse and tailings densification. We synthesized amylopectin‐graft‐poly[(2‐methacryloyloxy)ethyl]trimethylammonium chloride (AP‐g‐PMETAC) copolymers with systematically varied graft frequency (N = 
Gustavo P. Zago, Reinaldo Giudici, João B. P. Soares   +2 more
wiley   +1 more source

Who is Overdosing? An Updated Picture of Overdose Deaths From 2008 to 2015

Health Services Research & Managerial Epidemiology, 2017
Purpose: To determine the role of opioids in drug overdose deaths in Allen County, Indiana between January 1, 2008, and December 31, 2015. Methods: File review of 418 overdose deaths was performed using Indiana State Department of Health death ...
Gregory Eigner, Brian Henriksen, Philip Huynh, David Murphy, Christopher Brubaker, Jana Sanders, Deborah McMahan   +6 more
doaj   +1 more source

Investigating the Cytoskeleton of DRGs Using Cryo‐Electron Microscopy and Deep Learning

Cytoskeleton, EarlyView.
ABSTRACT We describe a method for determining the ultrastructural organization of axons and varicosities of cultured dorsal root ganglion (DRG) neurons using cryogenic electron microscopy (cryo‐EM). Cryo‐EM reveals the dimensions, proximity, and overall organization of biological specimens in a near‐native state, avoiding artifacts of fixation and ...
M. Neal Waxham, Mihir Relan, Matthew T. Swulius, Andrea K. H. Stavoe   +3 more
wiley   +1 more source

Prediction of Acute Liver Injury Trajectory in Patients Following Acetaminophen Overdose: A Multibiomarker Machine Learning Proof‐of‐Concept Study

Clinical Pharmacology &Therapeutics, EarlyView.
Clinical translation of novel therapies can be hindered by heterogeneity‐driven sample size inflation in late‐stage trials. In acetaminophen‐induced liver injury (APAP DILI), many patients recover spontaneously, diluting investigational drug efficacy signals.
Chris Humphries, Alastair M. Kilpatrick, Kathleen M. Scullion, Rhona Aird, Lorraine Bruce, Maria Elena Candela, Tak Yung Man, Stuart J. Forbes, James W. Dear   +8 more
wiley   +1 more source

Addressing Prescription Drug Abuse in the United States: Current Activities and Future Opportunities [PDF]

The United States is in the midst of an unprecedented drug overdose epidemic. Drug overdose death rates have increased five-fold since 1980.1 By 2009, drug overdose deaths outnumbered deaths due to motor vehicle crashes for the first time in the U.S ...

core  

Virtual Twin Approach Using Physiologically Based Pharmacokinetic Modeling to Support Precision Dosing of Valproic Acid in Geriatric Patients

Clinical Pharmacology &Therapeutics, EarlyView.
Personalized dosing is particularly important for drugs with narrow therapeutic indices in geriatric patients, who exhibit substantial physiological variability and limited pharmacokinetic (PK) evidence to guide individualized dose selection. Valproic acid (VPA) is an effective treatment option for bipolar disorder in older adults, yet dosing largely ...
Yoo Jin Jang, Dong‐Gyu Heo, Eunjin Hong   +2 more
wiley   +1 more source

Dependence, abuse, and psychosocial characteristics of patients transported to the emergency department due to overdose of over‐the‐counter drugs

PCN Reports
Aim This study examined the conditions of drug abuse and dependence as well as the psychosocial characteristics of patients transported to an emergency department for over‐the‐counter (OTC) drug overdose.
Saeko Kohara, Michiko Takai, Ryoko Kyan, Kenji Yamamoto, Hidehito Miyazaki, Masafumi Yoshimura, Yoshito Kamijo   +6 more
doaj   +1 more source

OVERDOSE PREVENTION RESEARCH PRIORITIES [PDF]

PROBLEM DESCRIPTION: The drug overdose epidemic in the United States continues to evolve and substantially impact individuals, families, and communities across the nation.

core  

Payload‐Based Clinical Pharmacology Review of Approved Antibody–Drug Conjugates: Commonalities and Considerations for Streamlined Development

Clinical Pharmacology &Therapeutics, EarlyView.
Antibody–drug conjugates (ADCs) combine the specificity of an antibody with the potency of a cytotoxic drug. Thirteen ADCs, utilizing seven unique cytotoxic payloads and targeting 11 distinct antigens, are currently approved by the US Food and Drug Administration as of June 2025, representing a rapidly growing and highly promising class of anticancer ...
Sijie Lu, Qingqing Xiao, Lixuan Qian, Siyuan Sun, Zhu Zhou, Michael Z. Liao, Chunze Li   +6 more
wiley   +1 more source