Results 111 to 120 of about 1,984,102 (295)

Experience of heroin overdose among drug users attending general practice. [PDF]

, 2000
Heroin overdose is responsible for significant mortality. It has not previously been highlighted as an important prevention or care issue for general practitioners involved in the management of drug misuse.
Langton, Deirdre, Cullen, Walter, Bury, Gerard   +2 more
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Polydatin Alleviates APAP‐Induced Hepatotoxicity by Targeting C/EBPβ to Suppress the NLRP3 Inflammasome Signaling Pathway

iNew Medicine, EarlyView.
PD alleviates APAP‐induced ALI by inhibiting the NLRP3 inflammasome signaling pathway. C/EBPβ is identified as a direct target via multimethod validation. PD promotes the deacetylation of C/EBPβ via Sirt1. The Sirt1/C/EBPβ/NLRP3 signaling axis is defined for PD's hepatoprotective effect.
Tian‐Yu Yang, Chen Wang, Yi Ding, Wei‐Kang Zhang, Ling Zheng, Li Yue, Lei Zhang   +6 more
wiley   +1 more source

Associations among drug acquisition and use behaviors, psychosocial attributes, and opioid-involved overdoses

BMC Public Health
Aims This study sought to develop and assess an exploratory model of how demographic and psychosocial attributes, and drug use or acquisition behaviors interact to affect opioid-involved overdoses.
James A. Swartz, Peipei Zhao, Ross Jacobucci, Dennis P. Watson, Mary Ellen Mackesy-Amiti, Dana Franceschini, A. David Jimenez   +6 more
doaj   +1 more source

Loneliness and fearfulness are associated with non-fatal drug overdose among people who inject drugs.

PLoS ONE
BackgroundPeople who inject drugs (PWID) experience high rates of drug overdose death with the risk of mortality increasing after each non-fatal event.
Oluwaseun Falade-Nwulia, Kathleen Ward, Karla D Wagner, Hamidreza Karimi-Sari, Jeffrey Hsu, Mark Sulkowski, Carl Latkin, Evaristus Nwulia   +7 more
doaj   +1 more source

Drug Overdose Death Rates in America Are Now Higher in Rural Areas Than Urban Areas

Learn more about how to prevent drug overdose.www.cdc.gov/drugoverdoseMMWR-Rural-Health-Series-drug-overdose-medium ...

core  

Microbial metabolite indole‐3‐propionic acid preserves astrocytic mitochondrial mitofusin 2 to limit neuroinflammation after traumatic brain injury

Interdisciplinary Medicine, EarlyView.
Following traumatic brain injury, indole‐3‐propionic acid (IPA) directly targets the aryl hydrocarbon receptor on astrocytes in the peri‐lesional cortex; this suppresses interferon regulatory factor 1‐driven transcription of the E3 ubiquitin ligase RFFL (ring finger and FYVE‐like domain containing E3 ubiquitin protein ligase).
Ziwen Zhang, Kai Wang, Liangbo Wang, Wencong Li, Hao Guo, Meng Xu, Tinghao Wang, Jiahui Ren, Ting Zhu, Jiahui Wang, Wenxing Cui, Jinpeng Zhou, Yang Tian, Liying Han, Chengxuan Guo, Shuoyao Ma, Qiang Wang, Zhihong Li, Yaning Cai, Jingyu Dong, Xun Wu, Haixiao Liu, Yan Qu   +22 more
wiley   +1 more source

Acute Modafinil Exposure Induces Neurobehavioral Alterations in Zebrafish: Implications for Off‐Label Cognitive Enhancement

Journal of Applied Toxicology, EarlyView.
ABSTRACT Modafinil (2‐(benzhydrylsulfinyl)acetamide) is a psychostimulant commonly prescribed for sleep disorders such as narcolepsy, excessive daytime sleepiness, and obstructive sleep apnea. Recently, its use has extended beyond clinical indications, with neurotypical individuals adopting it as a smart drug to enhance alertness and cognitive ...
Luciane Dellazari da Silva do Prado, Nicole Berton, Nicoli da Rosa Amaral, Inara Carbonera Biazus, Laíse Mattiollo, Jéssica Nardi, Karen Júlia de Souza dos Santos, Natália Freddo, Leonardo José Gil Barcellos, Luciana Grazziotin Rossato‐Grando   +9 more
wiley   +1 more source

Repeated Exposure to a Hair Bleaching Mixture Alters cGAS–STING Pathway Transcripts in Mice

Journal of Applied Toxicology, EarlyView.
ABSTRACT Hair bleaching products commonly contain ammonia and hydrogen peroxide, chemicals capable of generating reactive oxygen species (ROS). However, their effects on innate immune signaling pathways associated with DNA damage remain poorly understood.
Leticia Rodrigues Sampaio, Marjori Lima Boblitz Parente, Ronald Feitosa Pinheiro   +2 more
wiley   +1 more source

The Link Between Opioid Misuse and Suicidal Ideation Is Strongest Among Sexual Minorities

Journal of Clinical Psychology, EarlyView.
ABSTRACT Opioid misuse and suicidal ideation (SI) are significant public health concerns in the United States, and incidence rates may be elevated among sexual minority people. We used data from the 2021 National Survey on Drug and Health (heterosexual, n = 39,647, lesbian/gay n = 1329, bisexual n = 3774) to investigate rates of opioid misuse and ...
Katherine Musacchio Schafer, Rachel M. Schott, Julia C. Dodd, Jameson K. Hirsch   +3 more
wiley   +1 more source

Changes in Drug Overdose Mortality and Selected Drug Type by State in the United States, 2022 to 2023

This report describes changes in age-adjusted drug overdose death rates between 2022 and 2023 by state (and the District of Columbia) and selected types of ...

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