Results 111 to 120 of about 92,382 (306)

Effects of Fomepizole on Acetaminophen Oxidative Metabolism: A Randomized, Crossover Study in Human Volunteers

Clinical Pharmacology &Therapeutics, EarlyView.
Acetaminophen overdose can cause liver injury. Hepatotoxicity results from N‐acetyl‐p‐benzoquinone imine (NAPQI), generated via cytochrome P450‐2E1 (CYP2E1). Acetylcysteine is the mainstay of treatment, but efficacy may be reduced with delayed administration or large ingestions.
Sidharth Anand, Nicholas A. Buckley, Paul Stathakis, Laura James, Larry Parker, Mitchell R. McGill, Angela L Chiew   +6 more
wiley   +1 more source

Providing health education on accidental drug overdose. [PDF]

, 2006
There is an association between intravenous drug use and increased risk of death due to overdose. This article reports on the evaluation of a health promotion programme to educate drug users on preventing an overdose and how to deal with an overdose if ...
Grogan, Loretto, Branagan, Olive
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Prescription Sequence Symmetry Analysis of Glucagon‐Like Peptide‐1 Receptor Agonists and Neuropsychiatric Conditions

Clinical Pharmacology &Therapeutics, EarlyView.
Glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) are increasingly prescribed for type 2 diabetes and weight management. However, conflicting evidence from preclinical, clinical, and pharmacovigilance studies suggests potential neuropsychiatric effects.
Maria J. Alfonso Arvez, Sam Wade, Darshna Goordeen, Jenni Ilomäki, Amanda J. Cross, Monica Langiu, George S. Q. Tan   +6 more
wiley   +1 more source

Investigation of the In Vitro and In Vivo Metabolism and μ‐Opioid Receptor Affinity of the Nitazene N‐Pyrrolidino Fluetonitazene

Drug Testing and Analysis, EarlyView.
Eight metabolites for N‐pyrrolidino fluetonitazene were identified in vitro, three of which (M2, M6 and M8) were present in an authentic urine sample. M2 was the most abundant in vivo metabolite and is a common marker metabolite of nitazepyne‐type substances.
Severin Zemp, Gaia Alluisetti, Wolfgang Weinmann, Bettina Schrag, Frank Sporkert, Maurine Leclerc, Katharina Elisabeth Grafinger   +6 more
wiley   +1 more source

Addressing Prescription Drug Abuse in the United States: Current Activities and Future Opportunities [PDF]

The United States is in the midst of an unprecedented drug overdose epidemic. Drug overdose death rates have increased five-fold since 1980.1 By 2009, drug overdose deaths outnumbered deaths due to motor vehicle crashes for the first time in the U.S ...

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Dependence, abuse, and psychosocial characteristics of patients transported to the emergency department due to overdose of over‐the‐counter drugs

PCN Reports
Aim This study examined the conditions of drug abuse and dependence as well as the psychosocial characteristics of patients transported to an emergency department for over‐the‐counter (OTC) drug overdose.
Saeko Kohara, Michiko Takai, Ryoko Kyan, Kenji Yamamoto, Hidehito Miyazaki, Masafumi Yoshimura, Yoshito Kamijo   +6 more
doaj   +1 more source

Exploring Cerumen as an Alternative Matrix for Drug Detection and Quantification: Method Development and Application in Clinical Samples

Drug Testing and Analysis, EarlyView.
An LC–MS/MS method was developed for the detection of 33 psychoactive medications in cerumen (earwax) and applied to the samples of 60 psychiatric inpatient volunteers. The findings highlighted the utility of cerumen as an innovative biospecimen in clinical toxicological analysis.
Dimitrios Phaedon Kevrekidis, Helen G. Gika, Georgios Panagiotoglou, Eleni Parlapani, Pavlos Pavlidis, Nikolaos Raikos   +5 more
wiley   +1 more source

OVERDOSE PREVENTION RESEARCH PRIORITIES [PDF]

PROBLEM DESCRIPTION: The drug overdose epidemic in the United States continues to evolve and substantially impact individuals, families, and communities across the nation.

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Understanding Consumption of Illicit Drugs and New Psychoactive Substances in Australia by Triangulating Drug Checking and Wastewater‐Based Epidemiology

Drug Testing and Analysis, EarlyView.
First Australian study combining wastewater‐based epidemiology and drug checking, demonstrating how complementary data sources enhance monitoring of illicit drugs and emerging psychoactive substances during high‐use periods. ABSTRACT Consumption of psychotropic drugs is a major economic and public health challenge in Australia.
Muhammad Usman, Malcolm McLeod, Dhayaalini Nadarajan, Joseph Clokey, Pritesh Prasad, Rory Verhagen, Benjamin Tscharke, Maurizio Quinto, Richard Bade   +8 more
wiley   +1 more source

Public Health Drug Overdose Surveillance Training Series for Local/Territorial Jurisdictions : Cumulative Evaluation Report [PDF]

In 2019, the Council of State and Territorial Epidemiologists (CSTE) developed a series of multistate drug overdose surveillance training workshops for public health teams conducting drug overdose surveillance in the twenty (20) state jurisdictions ...

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