Results 121 to 130 of about 92,110 (306)

Circumstances of Witnessed Drug Overdose in New York City: Implications for Intervention [PDF]

, 2005
Drug users frequently witness the nonfatal and fatal drug overdoses of their peers, but often fail to intervene effectively to reduce morbidity and mortality.We assessed the circumstances of witnessed heroin-related overdoses in NewYork City (NYC) among
Galea, Sandro, Tracy, Melissa, Bucciarelli, Angela, Ompad, Danielle C., Coffin, Phillip O., Piper, Tinka Markham, Vlahov, David   +6 more
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Investigation of the In Vitro and In Vivo Metabolism and μ‐Opioid Receptor Affinity of the Nitazene N‐Pyrrolidino Fluetonitazene

Drug Testing and Analysis, EarlyView.
Eight metabolites for N‐pyrrolidino fluetonitazene were identified in vitro, three of which (M2, M6 and M8) were present in an authentic urine sample. M2 was the most abundant in vivo metabolite and is a common marker metabolite of nitazepyne‐type substances.
Severin Zemp, Gaia Alluisetti, Wolfgang Weinmann, Bettina Schrag, Frank Sporkert, Maurine Leclerc, Katharina Elisabeth Grafinger   +6 more
wiley   +1 more source

Drug overdose deaths among women 1999–2021 in the United States: Differences by race, ethnicity, and age

Women's Health
Background: The U.S. drug overdose epidemic is increasingly severe and steep increases have been seen among women. Objective: To explore trends in drug overdose deaths among women in the United States by race, ethnicity, and age group. Design: This study
Abenaa A Jones, Joel E Segel, Emma M Skogseth, Hannah B Apsley, Alexis R Santos-Lozada   +4 more
doaj   +1 more source

2018 Annual surveillance report of drug-related risks and outcomes -- United States [PDF]

This is the second annual surveillance report summarizing the latest information at the national level for prescribing patterns, drug use, and nonfatal and fatal overdose related to the current drug overdose epidemic in the United States.

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Exploring Cerumen as an Alternative Matrix for Drug Detection and Quantification: Method Development and Application in Clinical Samples

Drug Testing and Analysis, EarlyView.
An LC–MS/MS method was developed for the detection of 33 psychoactive medications in cerumen (earwax) and applied to the samples of 60 psychiatric inpatient volunteers. The findings highlighted the utility of cerumen as an innovative biospecimen in clinical toxicological analysis.
Dimitrios Phaedon Kevrekidis, Helen G. Gika, Georgios Panagiotoglou, Eleni Parlapani, Pavlos Pavlidis, Nikolaos Raikos   +5 more
wiley   +1 more source

Changes in Drug Overdose Mortality and Selected Drug Type by State in the United States, 2022 to 2023

This report describes changes in age-adjusted drug overdose death rates between 2022 and 2023 by state (and the District of Columbia) and selected types of ...

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Dapagliflozin alleviates high‐fat‐induced obesity cardiomyopathy by inhibiting ferroptosis

ESC Heart Failure, Volume 12, Issue 2, Page 1358-1373, April 2025.
Abstract Aim: Dapagliflozin (Dapa) is a novel hypoglycaemic agent with multiple cardiovascular protective effects, and it is widely used in treatment of heart failure patients, but whether it can improve obese phenotype of heart failure and its mechanism is still unclear.
Di Chen, Jiahao Shi, Yue Wu, Lizhu Miao, Zilin Wang, Yixuan Wang, Siwei Xu, Yu Lou   +7 more
wiley   +1 more source

Effects of fenfluramine and sigma‐1‐dependent pharmacological and genetic modulation in a mouse kindling model

Epilepsia, EarlyView.
Abstract Objective Sigma‐1 is a chaperone protein that serves as a key homeostatic regulator, implicated in neuronal excitability and seizure control. Positive allosteric modulators offer a use‐dependent means to enhance Sigma‐1 activity, potentially with favorable tolerability compared to direct agonists.
Eva‐Lotta von Rüden, Verena Buchecker, Amelie Wagner, Victoria M. Stocker, Liga Zvejniece, Heidrun Potschka   +5 more
wiley   +1 more source

Associations among drug acquisition and use behaviors, psychosocial attributes, and opioid-involved overdoses

BMC Public Health
Aims This study sought to develop and assess an exploratory model of how demographic and psychosocial attributes, and drug use or acquisition behaviors interact to affect opioid-involved overdoses.
James A. Swartz, Peipei Zhao, Ross Jacobucci, Dennis P. Watson, Mary Ellen Mackesy-Amiti, Dana Franceschini, A. David Jimenez   +6 more
doaj   +1 more source

Former prisoners are most at risk from drug overdose after jail release or cash windfall.

Former prisoners were most at risk from a drug overdose following a cash windfall, or immediately after leaving rehab or jail, a campaign to combat drug deaths said. An information sheet for vulnerable users said people also needed to be aware of “common
Foxe, Ken
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