Results 121 to 130 of about 92,382 (306)

Dapagliflozin alleviates high‐fat‐induced obesity cardiomyopathy by inhibiting ferroptosis

open access: yesESC Heart Failure, Volume 12, Issue 2, Page 1358-1373, April 2025.
Abstract Aim: Dapagliflozin (Dapa) is a novel hypoglycaemic agent with multiple cardiovascular protective effects, and it is widely used in treatment of heart failure patients, but whether it can improve obese phenotype of heart failure and its mechanism is still unclear.
Di Chen   +7 more
wiley   +1 more source

Urban\u2013rural differences in drug overdose death rates, by sex, age, and type of drugs onvolved, 2017 [PDF]

open access: yes
Key findingsData from the National Vital Statistics System, MortalityThe age-adjusted rate of drug overdose deaths was higher in urban than in rural counties (22.0 and 20.0 per 100,000, respectively).For males, rates were higher in urban than in rural ...

core  

Trends in overdose and other drug-induced deaths in Australia, 2004-2023 [PDF]

open access: yes
The National Illicit Drug Indicators Project provides epidemiological data on trends over time in drug-related harms and forms part of the broader Drug Trends program.
Chrzanowska, Agata ; https://orcid.org/   +4 more
core   +2 more sources

Poisoning and drug overdoses in the Emergency Department at Songklanagarind Hospital

open access: yesJournal of Health Science and Medical Research (JHSMR), 2010
Objective: To study the prevalence of poisoning and drug overdoses in the Emergency Department (ED) Songklanagarind Hospital. Material and Methods: A Retrospective study from January 1, 2007 to December 31, 2007. The records of all patients who presented
Chaipluk Sriprapan   +1 more
doaj  

An individual-based dynamic model to assess interventions to mitigate opioid overdose risk

open access: yesHarm Reduction Journal
Background Illicit opioid overdose continues to rise in North America and is a leading cause of death. Mathematical modeling is a valuable tool to investigate the epidemiology of this public health issue, as it can characterize key features of population
Kirsten Gallant, Ryan Lukeman
doaj   +1 more source

Effects of fenfluramine and sigma‐1‐dependent pharmacological and genetic modulation in a mouse kindling model

open access: yesEpilepsia, EarlyView.
Abstract Objective Sigma‐1 is a chaperone protein that serves as a key homeostatic regulator, implicated in neuronal excitability and seizure control. Positive allosteric modulators offer a use‐dependent means to enhance Sigma‐1 activity, potentially with favorable tolerability compared to direct agonists.
Eva‐Lotta von Rüden   +5 more
wiley   +1 more source

Prescription drug poisoning/overdose in Oregon [PDF]

open access: yes, 2015
This archived document is maintained by the Oregon State Library as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.Title from PDF caption (viewed on May 1, 2015)."Updated ...

core  

Drug overdose deaths among women 1999–2021 in the United States: Differences by race, ethnicity, and age

open access: yesWomen's Health
Background: The U.S. drug overdose epidemic is increasingly severe and steep increases have been seen among women. Objective: To explore trends in drug overdose deaths among women in the United States by race, ethnicity, and age group. Design: This study
Abenaa A Jones   +4 more
doaj   +1 more source

Drug involvement in fatal overdoses

open access: yesSSM - Population Health, 2017
Death certificate data from the Multiple Cause of Death (MCOD) files were analyzed to better understand the drug categories most responsible for the increase in fatal overdoses occurring between 1999 and 2014. Statistical adjustment methods were used to account for the understatement in reported drug involvement occurring because death certificates ...
openaire   +3 more sources

Unique deficits in place coding across subfields of the hippocampus in a mouse model of temporal lobe epilepsy

open access: yesEpilepsia, EarlyView.
Abstract Objective Memory problems are comorbid with temporal lobe epilepsy (TLE). Animal models of TLE reveal impairments in spatial firing fields of hippocampal place cells, providing a potential neural substrate for memory problems. Each subfield of the hippocampus carries out unique aspects of spatial memory, yet little is known about how ...
Brittney L. Boublil   +4 more
wiley   +1 more source

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