Results 171 to 180 of about 3,856,896 (414)

Who is Overdosing? An Updated Picture of Overdose Deaths From 2008 to 2015

open access: yesHealth Services Research & Managerial Epidemiology, 2017
Purpose: To determine the role of opioids in drug overdose deaths in Allen County, Indiana between January 1, 2008, and December 31, 2015. Methods: File review of 418 overdose deaths was performed using Indiana State Department of Health death ...
Gregory Eigner   +6 more
doaj   +1 more source

Noradrenergic and cholinergic innervation of the normal human heart and changes associated with cardiomyopathy

open access: yesThe Anatomical Record, EarlyView.
Abstract Autonomic nerves are crucial in cardiac function and pathology. However, data on the distribution of cholinergic and noradrenergic nerves in normal and pathologic human hearts is lacking. Nonfailing donor hearts were pressure‐perfusion fixed, imaged, and dissected. Left ventricular cardiomyopathy samples were also obtained.
Peter Hanna   +15 more
wiley   +1 more source

Dietary supplement of sodium butyrate improves the growth performance and intestinal health by targeting Wnt/β‐catenin signaling pathway in rabbits

open access: yesAnimal Research and One Health, EarlyView.
Dietary supplement of sodium butyrate, may relate to regulating intestinal health and thus the growth performance and meat quality of rabbits by regulating the continuous process of promoting the periodic cycle of cecal epithelial cells. Abstract Supplementation of sodium butyrate (SB) has been proved to be beneficial for improving the growth ...
Mengke Ni   +8 more
wiley   +1 more source

Feasibility and population exposure of 5‐fluorouracil using therapeutic drug monitoring (PREDICT‐5FU): A multicentre clinical trial

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aim PREDICT‐5FU aimed to document 5‐fluorouracil (5FU) exposure in a cancer population and to evaluate the feasibility of 5FU and capecitabine therapeutic drug monitoring (TDM) in patients receiving standard doses and schedules. Methods Multicentre, prospective, observational single‐arm study.
Sarah Glewis   +12 more
wiley   +1 more source

Effect of hydration schedules on dose‐limiting toxicity in patients with head and neck squamous cell carcinoma treated with cisplatin

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Abstract Aims The aim of this study was to determine if head and neck squamous cell carcinoma (HNSCC) patients treated with cisplatin chemoradiotherapy and short hydration (SH) experience less dose‐limiting toxicity (DLT) and receive more cisplatin than those with medium hydration (MH) or long hydration (LH).
Anouk W. M. A. Schaeffers   +10 more
wiley   +1 more source

Large Language Models for Drug Overdose Prediction from Longitudinal Medical Records [PDF]

open access: yesarXiv
The ability to predict drug overdose risk from a patient's medical records is crucial for timely intervention and prevention. Traditional machine learning models have shown promise in analyzing longitudinal medical records for this task. However, recent advancements in large language models (LLMs) offer an opportunity to enhance prediction performance ...
arxiv  

A Knowledge Graph-based Approach for Exploring the U.S. Opioid Epidemic [PDF]

open access: yesarXiv, 2019
The United States is in the midst of an opioid epidemic with recent estimates indicating that more than 130 people die every day due to drug overdose. The over-prescription and addiction to opioid painkillers, heroin, and synthetic opioids, has led to a public health crisis and created a huge social and economic burden.
arxiv  

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