Results 181 to 190 of about 235,245 (306)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Critical Analysis of Fixed-Dose Antibiotic Combinations Sold in Kinshasa-Democratic Republic of the Congo. [PDF]

Antibiotics (Basel)
Mankulu JK, Ive DK, Kasago FM, Mpuya EM, Mfuamba BK, Mufusama Koy Sita JP, Ciza Hamuli P, Kimbeni Malongo T, Mbinze Kindenge J, Liesse Iyamba JM, Mana Kialengila D.   +10 more
europepmc   +1 more source

Packaging challenge for COVID-19 drug [PDF]

, 2020
Chand Anupam
openalex   +1 more source

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

Comprehensive E-Cigarette Policies Are Associated With Lower Use Among U.S. Adolescents and Young Adults. [PDF]

J Stud Alcohol Drugs
Kcomt L, Mongilio J, Lim C, Clift J, Pasman E, Evans-Polce RJ.   +5 more
europepmc   +1 more source

Research on Inclusive Design Strategies for Packaging of OTC Drugs for the Elderly [PDF]

Keyi Huang
openalex   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Exploring Influencing Factors of Medication Adherence Among Chinese Patients With Alzheimer Disease: Delphi Study Informing Future Artificial Intelligence-Supported Interventions. [PDF]

JMIR Form Res
Zhang X, Elmansy R.
europepmc   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Commentary Paper on Cooling Flavors in Cigarette and Non-Cigarette Tobacco Products. [PDF]

Nicotine Tob Res
Bansal-Travers M, Villanti AC, Page MK, Goniewicz ML, O'Connor RJ, Giovenco DP, Krishnan-Sarin S, Bold KW, Barnes AJ, Price SM.   +9 more
europepmc   +1 more source