Results 201 to 210 of about 235,245 (306)

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Environmental resource footprinting of drug manufacturing : effects of scale up and drug administration [PDF]

, 2013
Boone, Lieselot, De Soete, Wouter, Dewulf, Jo, Heirman, Bert, Willemse, Filip   +4 more
core   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Identical drug packaging: Heparin and midazolam-yet another instance of similar drug packaging

Annals of Cardiac Anaesthesia, 2009
Misra Satyajeet, Koshy Thomas, Sinha Prabhat   +2 more
doaj  

A framework for enhancing pharmaceutical integrity and patient safety: novel mobile health solution integrating smart packaging and computer vision. [PDF]

Sci Rep
K H, Parikh V, K PS, D S, S RVI.
europepmc   +1 more source

Proposed initial drug dosage in normal renal/hepatic function, hepatic impairment, and renal impairment based on package insert and pharmacokinetic studies.

Harri Hardi (21571490), Zahra Fitrianti (21571496), Karen Elliora Utama (21807507), Ananda Pipphali Vidya (21807510), Nurul Gusti Khatimah (21807513), Kevin Aristyo (21807516), Hana Khairina Putri Faisal (21807519), Vivian Soetikno (10231437)   +7 more
openalex   +1 more source

EFFECTIVENESS OF INFORMATION, EDUCATION AND COMMUNICATION (IEC) PACKAGE ON KNOWLEDGE AND ATTITUDE REGARDING OVER THE COUNTER (OTC) DRUGS AMONG ADULTS

, 2020
R. Jayalakshmi, S. Ani Grace Kalaimathi
openalex   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

''Sugar for the Heart'', a bitter pill for tenecteplase: the crystallisation trap of pre-hospital fibrinolysis. [PDF]

Scand J Trauma Resusc Emerg Med
Prevautel T, Adet A, Michoud G.
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source