Results 201 to 210 of about 2,010 (261)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

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Residual contamination in antineoplastic drug packaging

Journal of Oncology Pharmacy Practice, 2023
Introduction The handling of antineoplastic drugs should follow strict supervision and safety rules to minimize the occupational exposure risks to professionals involved. The external surface contamination of drug vials is recognized as a health risk. So, our goal was to determine if there is residual contamination on the vials and containers surface ...
Luciana Stein e Silva, Cibele da Silva Barbosa Machado, Rafael Linden, Marina Venzon Antunes, Laura Cé da Silva, Carlos Alberto Yasin Wayhs, Edison Capp, Sandro Luís Ribeiro Ness   +7 more
openaire   +2 more sources

A drug-to-drug interaction package

Computer Methods and Programs in Biomedicine, 1989
This paper describes an electronic database for handling the interactions between active principles administered to various patients. The computer used is a personal computer with adequate mass memory, software, and data obtained from pharmacological sources.
PINCIROLI, FRANCESCO, POZZI, GIUSEPPE
openaire   +3 more sources

Packaging RNA drugs into extracellular vesicles

Nature Biomedical Engineering, 2020
The therapeutic dose of small interfering RNA can be reduced by endogenously expressing and packaging the RNA into extracellular vesicles through its integration with the backbone of a highly enriched pre-microRNA.
van Eijndhoven, Monique A J, Baglio, S Rubina, Pegtel, D Michiel   +2 more
openaire   +3 more sources

Clariant sells drug packaging business

C&EN Global Enterprise, 2019
Clariant has agreed to sell its health-care packaging business to Arsenal Capital Partners for $314 million.
openaire   +1 more source

Drug Packaging Invites Confusion

Anesthesiology, 1981
P, Freund, R J, Ward
openaire   +2 more sources

Similar Packaging of Ophthalmic Drugs

American Journal of Ophthalmology, 1981
L, Partamian, M, Kass
openaire   +2 more sources

Ophthalmic Drugs with Similar Packaging

American Journal of Ophthalmology, 1982
N N, Katz, E G, Foer
openaire   +2 more sources

Drug-Packaging Standards for Eye Drop Medications

Archives of Ophthalmology, 1988
To the Editor. —In a recent correspondence, the misuse of eye drops due to interchanged caps was presented. 1 The authors suggested a system for color-coding the bottle caps and labels of topical ophthalmic medications to decrease the incidence of confusion with similar bottles and the possibility of inadvertently misusing medications. This has been a
openaire   +2 more sources