AARS2‐SIRT5‐Driven DLD K445 Lactylation Promotes Cuproptosis Resistance in Glioblastoma Stem Cells
Advanced Science, EarlyView.Lactylation of DLD at K445 by AARS2 suppresses PDH complex activity and reduces DLAT lipoylation, thereby conferring cuproptosis resistance in glioblastoma stem cells. SIRT5‐mediated delactylation restores PDH function and enhances cuproptosis sensitivity.
Mingtian Ding +12 more
wiley +1 more source
If Supply-Oriented Drug Policy is Broken, Can Harm Reduction Help Fix It?—Melding Disciplines and Methods to Advance International Drug Control Policy [PDF]
Critics of the international drug control regime contend that supply-oriented policy interventions are not just ineffective, but they also produce unintended adverse consequences. Research suggests their claims have merit.
Victoria A. Greenfield, Letizia Paoli
core
Advanced Science, EarlyView.Lactate accumulation after SCI promotes H4K12la lactylation, which upregulates NDUFS7, triggering mitochondrial RET and ROS, enforcing pro‐inflammatory microglial polarization. MM@mPTC, a biomimetic nanotherapeutic, degrades LDHA in activated microglia, reducing H4K12la lactylation and blocking RET, thus curbing ROS, fostering a reparative phenotype ...
Chenglong Hong +13 more
wiley +1 more source
Harm Reduction or Psychedelic Support? Caring for Drug-Related Crises at Transformational Festivals
Dancecult: Journal of Electronic Dance Music Culture, 2015 Many of the EDM events known as “transformational festivals” provide psychedelic support spaces: volunteer projects caring for festivalgoers undergoing difficult drug experiences. Mostly drawn from the festival community, many volunteer carers (“sitters”)
Deirdre Ruane
doaj
Advanced Science, EarlyView.Incomplete microwave ablation induces animmunosuppressive microenvironment in tumor‐draining lymph nodes. An albumin‐based lipoprotein nanosystem enables coordinated delivery of immunomodulators to tumor‐draining lymph nodes and residual tumors, reverses post‐ablation immunosuppression, suppresses residual tumor growth, and promotes durable antitumor ...
Xuexia Shan +14 more
wiley +1 more source
Implications of the South African National Drug Policy on prescribing patterns: a case study of the Limpopo province. [PDF]
J Pharm Policy Pract, 2023 Akunne OO +4 more
europepmc +1 more source
Advanced Science, EarlyView.Field‐driven active colloids are framed as distributed micromachines in which externally supplied power, sensing, and control regulate task‐relevant states. By closing the loop between particle behavior, imaging, computation, and electric or magnetic actuation, these systems can progress from programmable motion toward adaptive functional outcomes ...
Ruchi Patel, Bhuvnesh Bharti
wiley +1 more source
Medical service pricing and pharmaceutical supply chain coordination contracts under the zero-markup drug policy. [PDF]
Front Public Health, 2023 Zhou N, Li S, Zhao G, Li C, Yu N.
europepmc +1 more source
Sweden and Holland – two drug policy models [Elektronisk resurs]
, 2003 It is a well known fact that since the 1960s, Sweden and Holland have developed completely different types of drug policy. But there are a number of misconceptions as to what the differences consist in and how they have arisen.
Lund University., Tops, Dolf,
core
“It should be hard to be a drug abuser” : An evaluation of the criminalization of drug use in Sweden
Background: Drug use was criminalized in Sweden in 1988 with aim of reducing the number of consumers and drug-related risks and harms. Imprisonment was introduced into the penalty scale in 1993 to improve the legislation's effectiveness.
Stenström, Albin, +2 more
core +1 more source