Results 61 to 70 of about 9,103,151 (355)
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Journal of Community Safety and Well-Being, 2023 Addressing the harms associated with criminalizing the problematic and addictive use of substances is a complex undertaking. In many cases, problematic substance use has a relationship to prior and current adversities and has been characterized as an ...
Janos Botschner +2 more
doaj +1 more source
Value in Health Regional Issues, 2018 The objectives of this article were to describe the characteristics of the drug policy in Romania in the last 10 years and to present the consequences in terms of patient accessibility to drugs.The Romanian health care system with pricing and reimbursement legislation was studied while considering the evolution of pricing and reimbursement processes ...
Ciprian-Paul, Radu +2 more
openaire +2 more sources
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Scientific ReportsTo assess the health utility value (HUV) of Rheumatoid Arthritis (RA) patients and its influencing factors in China. A cross-sectional survey was conducted in 8 tertiary hospitals across four capital-cities.
Chuchuan Wan +4 more
doaj +1 more source
Frontiers in PsychiatryIntroductionBurnout is a widespread issue among physicians globally, with pronounced gender disparities observed in China. This paper aims to analyze the collaboration characteristics between clinical pharmacists and physicians in China, examine the ...
Yuancheng Jiang +5 more
doaj +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Value in Health Regional Issues, 2017 We present a brief overview of the health care system in Hungary, focusing particularly on the pricing and reimbursement procedures of medicines. The National Institute of Health Insurance Fund Management is responsible for the administration of the health insurance system and public reimbursement of health technologies.
András, Inotai +3 more
openaire +2 more sources
Orphans in the Market: The History of Orphan Drug Policy
Social history of medicine : the journal of the Society for the Social History of Medicine, 2017 Summary This paper examines the history of orphan drug policy, from the emergence of ‘orphans’ in the American pharmaceutical market in the 1960s, through the debates and agitations that resulted in the passage of the US Orphan Drug Act of 1983, to ...
Koichi Mikami
semanticscholar +1 more source
FEBS Open Bio, EarlyView.This review provides an overview of bio‐based polymer sources, their unique functional properties and their environmental impact, and addresses their role as sustainable alternatives. It discusses end‐of‐life options, including composting and anaerobic digestion for renewable energy.
Sabina Kolbl Repinc +8 more
wiley +1 more source