Results 51 to 60 of about 195,352 (95)
DeepDDS: deep graph neural network with attention mechanism to predict synergistic drug combinations [PDF]
arXiv, 2021 Drug combination therapy has become a increasingly promising method in the treatment of cancer. However, the number of possible drug combinations is so huge that it is hard to screen synergistic drug combinations through wet-lab experiments. Therefore, computational screening has become an important way to prioritize drug combinations.
arxiv
Predicting Drug Responses by Propagating Interactions through Text-Enhanced Drug-Gene Networks [PDF]
arXiv, 2019 Personalized drug response has received public awareness in recent years. How to combine gene test result and drug sensitivity records is regarded as essential in the real-world implementation. Research articles are good sources to train machine predicting, inference, reasoning, etc.
arxiv
When deep learning meets causal inference: a computational framework for drug repurposing from real-world data [PDF]
arXiv, 2020 Drug repurposing is an effective strategy to identify new uses for existing drugs, providing the quickest possible transition from bench to bedside. Existing methods for drug repurposing that mainly focus on pre-clinical information may exist translational issues when applied to human beings. Real world data (RWD), such as electronic health records and
arxiv
ASGARD: A Single-cell Guided pipeline to Aid Repurposing of Drugs [PDF]
arXiv, 2021 Intercellular heterogeneity is a major obstacle to successful precision medicine. Single-cell RNA sequencing (scRNA-seq) technology has enabled in-depth analysis of intercellular heterogeneity in various diseases. However, its full potential for precision medicine has yet to be reached.
arxiv
A Case of Intertriginous and Flexural Exanthema caused by Amoxicillin
Sultan Qaboos University Medical Journal, 2019 We report a 50-year-old male patient who presented to the Dermatological Outpatient Clinic at the Hospital Universitario San Cecilio, Granada, Spain, in 2017 with symmetrical inguinal eruption and eruption on the dorsum of both feet four hours after the ...
Bárbara Cancela-Díez +3 more
doaj +1 more source
Hypopigmented penile fixed drug eruption
Clinical Case Reports, 2022 Fixed drug eruptions (FDE) are typically associated with residual hyperpigmentation or non‐pigmenting lesions. There is no distinctive histopathological feature; though, drug provocation tests (DPT) can be confirmatory within 7 days.
Perpetua U. Ibekwe +5 more
doaj +1 more source
Allergy, Asthma & Clinical Immunology, 2020 Current recommendations for the management of penicillin allergy are to perform penicillin skin testing (PST) with penicilloyl-polylysine (PPL) and benzylpenicillin (BP) prior to drug challenge with amoxicillin.
Roxane Labrosse +6 more
doaj +1 more source
Journal of International Medical ResearchPregabalin is the first-line treatment for neuropathic pain. Cases of cutaneous hypersensitivity reactions caused by pregabalin generally occur within 2 weeks of initiating medication.
Mi Zhang +7 more
doaj +1 more source
Prague Medical Report, 2018 The current diagnostic algorithm for beta-lactam allergy is based on skin and provocation tests, both of which carry a certain risk of inducing hypersensitivity reactions.
Lenka Sedláčková +3 more
doaj +1 more source
The Role of the Basophil Activation Test in the Diagnosis of Drug-Induced Anaphylaxis
DiagnosticsThe diagnosis of drug-induced anaphylaxis (DIA) is a serious health problem. The Basophil activation test (BAT) is considered a specific in vitro provocation, and compared to in vivo provocation, it is more convenient, cheaper, and safer for the patient.
Maria Czarnobilska +4 more
doaj +1 more source