Results 41 to 50 of about 11,154 (267)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Hydroxychloroquine and Fabry Disease: Three Case Reports Examining an Unexpected Pathologic Link and a Review of the Literature

Case Reports in Rheumatology, 2022
Background. Hydroxychloroquine is an effective and widely used treatment in multiple autoimmune connective tissue diseases that gained a lot of publicity in the coronavirus disease 2019 (COVID-19) pandemic.
Rouhin Sen, Kathleen Borghoff, Kirk W. Foster, Stanley J. Radio, Alan Erickson, Michelene Hearth-Holmes   +5 more
doaj   +1 more source

PubChem as a public resource for drug discovery [PDF]

Drug Discovery Today, 2010
PubChem is a public repository of small molecules and their biological properties. Currently, it contains more than 25 million unique chemical structures and 90 million bioactivity outcomes associated with several thousand macromolecular targets. To address the potential utility of this public resource for drug discovery, we systematically summarized ...
Qingliang, Li, Tiejun, Cheng, Yanli, Wang, Stephen H, Bryant   +3 more
openaire   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Intercambialidade de medicamentos: abordagem clínica e o ponto de vista do consumidor Drug interchangeability: clinical approach and consumer's point of view

Revista de Saúde Pública, 2006
A construção racional do arsenal terapêutico, considerando a necessidade do paciente, a segurança e a disponibilidade do medicamento, e o melhor custo-benefício pressupõem embasamento na tríade: segurança, eficácia e qualidade.
Davi Rumel, Sérgio de Andrade Nishioka, Adélia Aparecida Marçal dos Santos   +2 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

La industria farmacéutica y la promoción de los medicamentos. Una reflexión necesaria

Gaceta Médica Espirituana, 2017
Fundamento: La industria farmacéutica a nivel internacional tiene entre sus estrategias la propaganda de medicamentos directa al consumidor, para incrementar sus ganancias.
Grisel Viña-Pérez, Francisco Debesa Garcia   +1 more
doaj  

The threat of carbapenem-resistant Enterobacteriaceae in Lebanon: An update on the regional and local epidemiology

Journal of Infection and Public Health, 2012
Summary: Bacterial resistance to antimicrobial agents is increasing. Complex resistant mechanisms have resulted in a wide spectrum of species and strains with multidrug-resistant patterns.
Rima I. El-Herte, Souha S. Kanj, Ghassan M. Matar, George F. Araj   +3 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Propagandas de medicamentos em revistas femininas

Saúde em Debate
Este artigo tem como objetivo analisar as propagandas de medicamentos veiculadas em revistas femininas de circulação nacional, conforme a RDC 102/00.
Marselle Nobre de Carvalho, José Augusto Cabral de Barros   +1 more
doaj   +2 more sources