Results 41 to 50 of about 1,839,920 (311)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Knowledge among Drug Dispensers and Antimalarial Drug Prescribing Practices in Public Health Facilities in Dar es Salaam. [PDF]

, 2013
Irrational prescribing and dispensing of antimalarials has been identified as a contributing factor in the emergence of malaria parasites resistant to existing antimalarial drugs.
Kamuhabwa AA, Silumbe R, Kamuhabwa, Appolinary Ar, Silumbe, Richard   +3 more
core   +1 more source

Perceptions of the benefits of the basic medical insurance system among the insured: a mixed methods research of a northern city in China

Frontiers in Public Health, 2023
BackgroundThe perceptions of the benefits of the basic medical insurance system among the insured not only reflect the system's performance but also the public's basic medical insurance policy literacy, valuable information for countries that have ...
Peng Wang, Peng Wang, Shuyi Li, Shuyi Li, Zhizhen Wang, Zhizhen Wang, Mingli Jiao, Mingli Jiao, Yuchao Zhang, Yuchao Zhang, Weiqi Huang, Weiqi Huang, Ning Ning, Ning Ning, Lijun Gao, Lijun Gao, Linghan Shan, Linghan Shan, Ye Li, Ye Li, Qunhong Wu, Qunhong Wu   +21 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Hydroxychloroquine and Fabry Disease: Three Case Reports Examining an Unexpected Pathologic Link and a Review of the Literature

Case Reports in Rheumatology, 2022
Background. Hydroxychloroquine is an effective and widely used treatment in multiple autoimmune connective tissue diseases that gained a lot of publicity in the coronavirus disease 2019 (COVID-19) pandemic.
Rouhin Sen, Kathleen Borghoff, Kirk W. Foster, Stanley J. Radio, Alan Erickson, Michelene Hearth-Holmes   +5 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Intercambialidade de medicamentos: abordagem clínica e o ponto de vista do consumidor Drug interchangeability: clinical approach and consumer's point of view

Revista de Saúde Pública, 2006
A construção racional do arsenal terapêutico, considerando a necessidade do paciente, a segurança e a disponibilidade do medicamento, e o melhor custo-benefício pressupõem embasamento na tríade: segurança, eficácia e qualidade.
Davi Rumel, Sérgio de Andrade Nishioka, Adélia Aparecida Marçal dos Santos   +2 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Western Hemisphere Drug Policy Commission [website]

, 2021
Website of the Western Hemisphere Drug Policy Commission (WHDPC), charged to "evaluate a range of US counternarcotics programs in the Americas and then make recommendations to improve them" -- including a recording and transcript of the group's hearing ...
United States. Western Hemisphere Drug Policy Commission.
core  

La industria farmacéutica y la promoción de los medicamentos. Una reflexión necesaria

Gaceta Médica Espirituana, 2017
Fundamento: La industria farmacéutica a nivel internacional tiene entre sus estrategias la propaganda de medicamentos directa al consumidor, para incrementar sus ganancias.
Grisel Viña-Pérez, Francisco Debesa Garcia   +1 more
doaj