Results 71 to 80 of about 9,770,479 (402)

Ergothioneine supplementation improves pup phenotype and survival in a murine model of spinal muscular atrophy

FEBS Letters, EarlyView.
Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile, Daniela Ratto, Giorgia Rastelli, Ottavia Eleonora Ferraro, Caterina Temporini, Sunil Kumar, Simona Boncompagni, Paola Rossi, Monica Canepari   +8 more
wiley   +1 more source

Cytomegalovirus infection initiates inflammatory bowel disease by activating a positive MyD88/NF-κB feedback loop in allogeneic skin transplantation mice

Virology Journal
Infection with the cytomegalovirus (CMV) is common. Inflammatory bowel disease (IBD) is characterized by chronic inflammation in the gastrointestinal tract. CMV infection is involved in IBD pathogenesis. The abnormal activation of myeloid differentiation
Ming-Xian Chen, Yu Chen, Rui Fu, Jie-Yi Wang, Sai-Yue Liu, Tang-Biao Shen   +5 more
doaj   +1 more source

Acute generalized exanthematous pustulosis induced by sulfasalazine: Uncommon presentation of a common culprit

Indian Journal of Rheumatology, 2022
Acute generalized exanthematous pustulosis (AGEP) is a severe cutaneous adverse drug reaction caused by drugs in the majority of cases. It is characterized by the sudden onset of nonfollicular sterile pustules, papules, and edematous plaques on an ...
Deepak Vashisht, Parul Kamboj, Manoj Gopal Madakshira, Preema Sinha, Arun Hegde, Juhi Sharma   +5 more
doaj   +1 more source

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

FEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source

Granulomatous Sarcoidosis Mimics

Frontiers in Medicine, 2021
Many granulomatous diseases can mimic sarcoidosis histologically and in terms of their clinical features. These mimics include infectious granulomatous diseases, granulomatous reactions to occupational and environmental exposures, granulomatous drug ...
Marc A. Judson
doaj   +1 more source

Factors Affecting Adverse Drug Reaction Reporting of Healthcare Professionals and Their Knowledge, Attitude, and Practice towards ADR Reporting in Nekemte Town, West Ethiopia

BioMed Research International, 2016
Background. Adverse drug reactions are global problems of major concern. Adverse drug reaction reporting helps the drug monitoring system to detect the unwanted effects of those drugs which are already in the market. Aims.
Lense Temesgen Gurmesa, Mohammed Gebre Dedefo   +1 more
semanticscholar   +1 more source

Electrochemical behaviour of carbamazepine in acetonitrile and dimethylformamide using glassy carbon electrodes and microelectrodes [PDF]

, 2010
The electrochemical reduction of carbamazepine in acetonitrile (ACN) and dimethylformamide (DMF) using a glassy carbon electrode and microelectrodes has been studied.
Anicet, Bardy, Cannes, Cantú, Carvalho, Farrington, Fisher, García-García, Hall, Jones, Jönsson, Kim, Longinotti, Mashayekhi, Moses, Nicholson, Pilgrim, Savéant, Sevilla, Spiller, Subramanian, Sullivan, Weaver   +22 more
core   +1 more source

Single cis‐elements in brassinosteroid‐induced upregulated genes are insufficient to recruit both redox states of the BIL1/BZR1 DNA‐binding domain

FEBS Letters, EarlyView.
Phytohormone brassinosteroid‐induced gene regulation by the transcription factor BIL1/BZR1 involves redox‐dependent DNA‐binding alternation and interaction with the transcription factor PIF4. The reduced BIL1/BZR1 dimer binds preferred cis‐elements, while oxidation alters its oligomerization state and disrupts DNA‐binding ability.
Shohei Nosaki, Masae Ohtsuka, Takeshi Nakano, Masaru Tanokura, Takuya Miyakawa   +4 more
wiley   +1 more source

Atox1 regulates macrophage polarization in intestinal inflammation via ROS-NLRP3 inflammasome pathway

Journal of Translational Medicine
Background Inflammation and oxidative stress play an important role in the pathophysiology of inflammatory bowel disease (IBD). This study aimed to explore the effects of copper chaperone Antioxidant-1 (Atox1) on macrophages in a mouse model of ...
MingXian Chen, Yu Chen, Rui Fu, SaiYue Liu, HaiXia Li, TangBiao Shen   +5 more
doaj   +1 more source

Exploring antibiotic safety: A prospective observational study from a tertiary care public sector hospital

Clinical Epidemiology and Global Health
Background: Antibiotics are the most commonly used drugs to treat bacterial infections; however, these life-saving drugs can also cause adverse drug reactions.
Garapati Pavan, Manish Kumar, Sameer Dhingra, Nitesh Kumar, Ravichandiran V, Krishna Murti   +5 more
doaj   +1 more source