Results 81 to 90 of about 1,787,106 (336)

A case report of cutaneous and systemic lupus erythematosus after bupropion usage

Turkish Journal of Internal Medicine, 2020
Bupropion is a drug used to smoke cessation. Various complications have been reported after using this drug. In a 58-year-old female patient, skin findings and anti-Ro52 positivity developed after the use of this drug. Later, signs of vasculitis appeared
Abdulmecit Yildiz, Mehmet Aydın, Saide Güllülü, Kamil Dilek, Oktay Ünsal, Alparslan Ersoy, Mahmut Yavuz, Mustafa Güllülü, Suat Akgür, Ayşegül Oruç   +9 more
doaj   +1 more source

Refining adverse drug reaction signals by incorporating interaction variables identified using emergent pattern mining [PDF]

, 2016
Purpose: To develop a framework for identifying and incorporating candidate confounding interaction terms into a regularised cox regression analysis to refine adverse drug reaction signals obtained via longitudinal observational data.
Bien, Brookhart, Brooks, Caster, Chambless, Cox, Davies, Goldman, Hahsler, Hoerl, Härmark, Jenna M. Reps, Lewis, Li, McGue, McMahon, Pirmohamed, Reps, Reps, Reps, Richard B. Hubbard, Ryan, Scheiber, Schneeweiss, Schuemie, Shepherd, Simon, Spruance, Therneau, Tibshirani, Uwe Aickelin, van Puijenbroek, Wu, Zou   +33 more
core   +3 more sources

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Extracting adverse drug reactions and their context using sequence labelling ensembles in TAC2017

, 2018
Adverse drug reactions (ADRs) are unwanted or harmful effects experienced after the administration of a certain drug or a combination of drugs, presenting a challenge for drug development and drug administration.
Belousov, Maksim, Dixon, William, Milosevic, Nikola, Nenadic, Goran   +3 more
core  

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Vegetable oil hybrid films cross-linked at the air-water interface: formation kinetics and physical characterization

, 2017
Vegetable oil based hybrid films were developed thanks to a novel solvent- and heating- free method at the air-water interface using silylated castor oil cross-linked via a sol-gel reaction.
Aubert-Pouessel, Anne, Bonnet, Laurent, Chopineau, Joel, Dieudonne-George, Philippe, Etienne, Pascal, Lapinte, Vincent, Massiera, Gladys, Oberdisse, Julian, Robin, Jean-Jacques, Theodoratou, Antigoni   +9 more
core   +2 more sources

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

Drug delivery systems - Winter school on recent advances in diagnosis and management of diseases in mariculture, 7th to 27th November 2002, Course Manual [PDF]

, 2002
Drug delivery systems are designed based on the action of the drug in the body, reaction of the body to these drugs and the active drug available in the body for therapeutic action.
Gopakumar, N
core