Results 41 to 50 of about 525,118 (262)

Drug related problems in older adults living with dementia.

PLoS ONE, 2020
BackgroundCompared with those without dementia, older patients with dementia admitted to acute care settings are at higher risk for triad combination of polypharmacy (PP), potentially inappropriate medication (PIM), and drug-drug interaction (DDI), which
Sirasa Ruangritchankul, Nancye M Peel, Leila Shafiee Hanjani, Leonard C Gray   +3 more
doaj   +1 more source

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

Prediction of drug-related problems in diabetic outpatients in a number of hospitals, using a modeling approach

Drug, Healthcare and Patient Safety, 2017
Ghaith M Al-Taani,1 Sayer I Al-Azzam,2 Karem H Alzoubi,2 Feras W Darwish Elhajji,3 Michael G Scott,4 Hamzah Alfahel,5 Mamoon A Aldeyab6 1Department of Pharmacy Practice, Faculty of Pharmacy, Yarmouk University, 2Department of Clinical Pharmacy, Faculty ...
Al-Taani GM, Al-Azzam SI, Alzoubi KH, Darwish Elhajji FW, Scott MG, Alfahel H, Aldeyab MA   +6 more
doaj  

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Identification and Resolution of Drug-related Problems Encountered by Individuals with Epilepsy in Nigeria

Archives of Epilepsy
Objective: Interventions by clinical pharmacists are required to identify and resolve medication-related problems. This study aimed to identify drug-related problems (DRPs) encountered by patients with epilepsy, provide pharmaceutical care (PC ...
Unyime Eshiet, Chukwuemeka Michael Ubaka, Nneka Igboeli   +2 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Outcomes and drug-related admissions of cardiovascular patients in the emergency department at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia

International Journal of Emergency Medicine
Introduction Cardiovascular diseases (CVDs) are the leading cause of death globally, with a rising prevalence. The increase in medications, recognized conditions, and polypharmacy has led to more drug-related problems and emergency admissions among ...
Hikma Husein, Tamrat Assefa Tadesse, Alemu Belayneh, Merahi Kefyalew, Mesfin Ayalew Tsegaye, Elias Gashaw Endegnanew, Matyas Wondwossen Elssa, Eskinder Ayalew Sisay   +7 more
doaj   +1 more source

Pharmacist interventions for older adults with polypharmacy in an ambulatory geriatric clinic

Health Literacy and Communication Open
Introduction Polypharmacy is a concern among older adults. An academic medical center in northeast Ohio currently has an outpatient geriatric medicine clinic with an embedded board-certified geriatric pharmacist who performs comprehensive medication ...
Antonietta Paneccasio, Anna Bondar, Emily Fargo, Marcie Parker, Ardeshir Hashmi, Kenneth Koncilja, Gina Elder   +6 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Patient involvement is essential in identifying drug‐related problems [PDF]

British Journal of Clinical Pharmacology, 2018
AimsThe aim of this study is to evaluate how critical patient involvement is in pharmacist‐led clinical medication reviews and in identifying the most significant clinical drug‐related problems (DRPs).MethodsPharmacist‐led clinical medication reviews were conducted with 161 consenting patients aged ≥75 years with at least seven prescribed medicines ...
Heini Kari, Hanna Kortejärvi, Marja Airaksinen, Raisa Laaksonen   +3 more
openaire   +2 more sources