Results 51 to 60 of about 14,448,012 (256)

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Drug related problems in older adults living with dementia.

PLoS ONE, 2020
BackgroundCompared with those without dementia, older patients with dementia admitted to acute care settings are at higher risk for triad combination of polypharmacy (PP), potentially inappropriate medication (PIM), and drug-drug interaction (DDI), which
Sirasa Ruangritchankul, Nancye M Peel, Leila Shafiee Hanjani, Leonard C Gray   +3 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Drug-related and drug-misuse deaths 2008-2018.

, 2020
There were 189 drug-related deaths registered in Northern Ireland in 2018. Half (95) of these deaths were of men aged 25-44. These are some of the findings of the statistics published today by the Northern Ireland Statistics and Research Agency (NISRA).

core  

Identification and Resolution of Drug-related Problems Encountered by Individuals with Epilepsy in Nigeria

Archives of Epilepsy
Objective: Interventions by clinical pharmacists are required to identify and resolve medication-related problems. This study aimed to identify drug-related problems (DRPs) encountered by patients with epilepsy, provide pharmaceutical care (PC ...
Unyime Eshiet, Chukwuemeka Michael Ubaka, Nneka Igboeli   +2 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Pharmacist interventions for older adults with polypharmacy in an ambulatory geriatric clinic

Health Literacy and Communication Open
Introduction Polypharmacy is a concern among older adults. An academic medical center in northeast Ohio currently has an outpatient geriatric medicine clinic with an embedded board-certified geriatric pharmacist who performs comprehensive medication ...
Antonietta Paneccasio, Anna Bondar, Emily Fargo, Marcie Parker, Ardeshir Hashmi, Kenneth Koncilja, Gina Elder   +6 more
doaj   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Outcomes and drug-related admissions of cardiovascular patients in the emergency department at Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia

International Journal of Emergency Medicine
Introduction Cardiovascular diseases (CVDs) are the leading cause of death globally, with a rising prevalence. The increase in medications, recognized conditions, and polypharmacy has led to more drug-related problems and emergency admissions among ...
Hikma Husein, Tamrat Assefa Tadesse, Alemu Belayneh, Merahi Kefyalew, Mesfin Ayalew Tsegaye, Elias Gashaw Endegnanew, Matyas Wondwossen Elssa, Eskinder Ayalew Sisay   +7 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source