Results 101 to 110 of about 3,939,397 (309)
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
Recent Advances in Polymeric Delivery Vehicles for Controlled and Sustained Drug Release
In the realm of modern therapeutics, the development of polymeric delivery vehicles has revolutionized drug administration, offering a sophisticated approach to controlled and sustained drug release [...
Hong Lu, Zheng Cai, Ping Hu
core +1 more source
Dynamic clinical trial success rates for drugs in the 21st century
Nature CommunicationsIn clinical drug development, two fundamental questions must be addressed: what is the success rate of drugs in clinical trial; how does such rate change over time. Here, a dynamic strategy for calculating clinical trial success rate (ClinSR) is proposed,
Ying Zhou +18 more
doaj +1 more source
Journal of Pharmaceutical AnalysisThe molecular complexity of active pharmaceutical ingredients (APIs) has increased over recent decades, with production largely relying on microbial processes such as fermentation.
Yangrui Zhang +8 more
doaj +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Zero-order drug release obtained with gradient matrix systems based on hydrophilic polymers
, 2011 The use of powder layering technology was explored to prepare hydrophilic matrix systems aimed at a zero-order release of drugs. Systems with 5 layers with decreasing drug concentration from the inner to the outer one were prepared by applying powders ...
A. Foppoli +5 more
core +2 more sources
The autophagic regulation of rosiglitazone-promoted adipocyte browning
Frontiers in PharmacologyObjective: Browning of white adipocytes is considered an efficient approach to combat obesity. Rosiglitazone induces the thermogenetic program of white adipocytes, but the underlying mechanisms remain elusive.Methods: Expression levels of browning and ...
Yue Li +7 more
doaj +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
Background and Objective: A previous study investigated the in vitro release of methylene blue (MB), a widely used cationic dye in biomedical applications, from nanocellulose/nanoporous silicon (NC/nPSi) composites under conditions simulating body fluids.
Paulo Zúñiga +3 more
core +1 more source
Modelling drug coatings: A parallel cellular automata model of ethylcellulose-coated microspheres [PDF]
, 2011 Pharmaceutical companies today face a growing demand for more complex drug designs. In the past few decades, a number of probabilistic models have been developed, with the aim of improving insight on microscopic features of these complex designs.
Crane, Martin +5 more
core +5 more sources