Results 81 to 90 of about 3,939,397 (309)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Targeted Enrichment of Engineered Bacteria on Triple‐Negative Breast Cancer Turns Immunologically Cold Tumors Hot

Advanced Science
Tumor immunotherapy has garnered significant attention, however, several notable challenges remain to be addressed, including: 1) enhancing active targeting, 2) effectively shielding immune checkpoints, and 3) inducing the transformation of “cold” tumor ...
Xuanxiang Zhai, Xiaoyi Shi, Xiao Liu, Xiaotong Gu, Wenting Li, Xiangjun Chen, Wei Hong   +6 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Photodynamic/Photothermal Gold Nanoclusters Chitosan Sponge for Hemostasis and MRSA Infected Wound Healing

International Journal of Nanomedicine
Xiaoyi Shi,1,* Jingqian Su,1,* Wenting Li,1 Keke Li,2 Xiangjun Chen,1 Wei Hong1 1School of Pharmacy, Shandong New Drug Loading & Release Technology and Preparation Engineering Laboratory, Binzhou Medical University, Yantai, Shandong ...
Shi X, Su J, Li W, Li K, Chen X, Hong W
doaj  

3D dynamic culture of muse cells on a porous gelatin microsphere after magnetic sorting: Achieving high purity proliferation

Regenerative Therapy
Muse cell has become a promising source of cells for disease treatment due to its remarkable characteristics, including stress tolerance, low tumorigenicity, effective homing ability, and differentiation into histocompatibility cells after ...
Zhe Lu, Shifeng Ren, Bingjie Wang, Yajun Zhang, Xiaodong Mu, Zhihui Wang   +5 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Flexible Coatings Facilitate pH-Targeted Drug Release via Self-Unfolding Foils:Applications for Oral Drug Delivery

Ingestible self-configurable proximity-enabling devices have been developed as a non-invasive platform to improve the bioavailability of drug compounds via swellable or self-unfolding devices.
Anja Boisen, Lasse Højlund Eklund Thamdrup, De Vittorio, Laura, Mahdi Ghavami, Nuray Göncü, Reece McCabe, Samvrta Krishnan, Milián-Guimerá, Carmen, Laura De Vittorio, Göncü, Nuray, Thamdrup, Lasse Højlund Eklund, Boisen, Anja, Carmen Milián-Guimerá, McCabe, Reece, Krishnan, Samvrta, Ghavami, Mahdi   +15 more
core   +1 more source

Remolding the tumor microenvironment by bacteria augments adoptive T cell therapy in advanced-stage solid tumors

Signal Transduction and Targeted Therapy
The intricate tumor microenvironment presents formidable obstacles to the efficacy of adoptive T cell therapy in the management of solid tumors by limiting the infiltration and inducing exhaustion of the transferred T cells.
Chaojie Zhu, Chao Liu, Qing Wu, Tao Sheng, Ruyi Zhou, En Ren, Ruizhe Zhang, Zhengjie Zhao, Jiaqi Shi, Xinyuan Shen, Zhongquan Sun, Zhengwei Mao, Kaixin He, Lingxiao Zhang, Yuan Ding, Zhen Gu, Weilin Wang, Hongjun Li   +17 more
doaj   +1 more source

Unveiling the bioactive landscape of drug inactive ingredients (DIGs) using deep transfer learning

Acta Pharmaceutica Sinica B
In a drug product, the major components by mass are the drug inactive ingredients (DIGs), which raises great concerns about their unwanted effects and clinical toxicities.
Minjie Mou, Jinsong Zhang, Xingang Liu, Hao Yang, Tingting Fu, Hengbin Zhang, Yimiao Zhu, Tianle Niu, Xuedong Li, Yichao Ge, Ziqi Pan, Xinyu Liu, Huaicheng Sun, Tianyuan Zhang, Yang Zhang, Feng Zhu, Jianqing Gao   +16 more
doaj   +1 more source