Results 91 to 100 of about 935,473 (268)

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Biodegradable implants for sustained drug release: Manufacturing considerations, drug stability, and drug release

Acta Ophthalmologica, 2017
SummaryPoly(D,L‐lactide‐co‐glycolide) (PLGA) is a biodegradable polymer used in preparing sustained release dosage forms including implants, microparticles, and nanoparticles. Indeed, an intravitreally injectable PLGA implant loaded with dexamethasone, an anti‐inflammatory corticosteroid, has been approved for treating retinal vein occlusion, posterior
openaire   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

NK‐Cell‐Derived Extracellular Vesicles Engineered to Carry Senolytics Eliminate Chemotherapy‐Induced Senescent Osteosarcoma Cells

Journal of Extracellular Vesicles
Osteosarcoma (OS) is a type of bone tumour characterized by high risk of metastatic progression and recurrence after therapy. Traditional tumour treatment methods such as radiotherapy and chemotherapy can lead to the accumulation of senescent cells in ...
Xianlin Yue, Jie Cui, Shifeng Ren, Yajun Zhang, Ying Li, Hongjuan Cui, Johnny Huard, Paul D. Robbins, Xiaodong Mu   +8 more
doaj   +1 more source

Extracellular vesicles for delivering therapeutic agents in ischemia/reperfusion injury

Asian Journal of Pharmaceutical Sciences
Ischemia/reperfusion (I/R) injury is marked by the restriction and subsequent restoration of blood supply to an organ. This process can exacerbate the initial tissue damage, leading to further disorders, disability, and even death. Extracellular vesicles
Weihang Zhou, Xinchi Jiang, Jianqing Gao
doaj   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Microneedle Patch for In Situ Neutrophil Monitoring

Advanced Science
Monitoring neutrophil levels plays an essential role in diagnosing infections and various diseases, as well as for managing specific treatments such as chemotherapy and radiotherapy. However, the traditional complete blood count technique is invasive and
Ziyi Lu, Ruisi Cai, Tianao Xie, Sheng Zhao, Sarun Juengpanich, Win Topatana, Shijie Li, Jiasheng Cao, Jiahao Hu, Tianen Chen, Jiachen Chen, Jicheng Yu, Tao Sheng, Wentao Zhang, Hao Wang, Jiahuan You, Yukai Shan, Yuchao Sun, Ruijing Shen, Zhengjie Zhao, Kangfan Ji, Ziqi Gao, Xinmin Yu, Xiujun Cai, Zhen Gu, Yuqi Zhang, Mingyu Chen   +26 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Interpretation of RNA Universe and Coding Potential Using IntRNA

Advanced Science
The interpretation of RNA universe and coding potential are long‐standing issues in modern RNA studies, and three crucial questions remain unanswered: a) how to detect and interpret the coding potential of RNA, b) how to annotate the sophisticated ...
Yunxia Wang, Minjie Mou, Shijie Huang, Wei Zhang, Ziqi Pan, Jing Tang, Yihao Wang, Qingxia Yang, Feng Zhu   +8 more
doaj   +1 more source