Results 91 to 100 of about 915,020 (267)

Synergistic effect of regorafenib with aminoglycosides in ferroptosis-mediated liver injury

Frontiers in Pharmacology
BackgroundCombination therapy of anticancer drugs with antibacterial agents has numerous advantages, but these may develop adverse drug events that were rarely studied.
Maha Raja Dahar, Maha Raja Dahar, Shaojun Zhou, Shaojun Zhou, Haihong Hu, Haihong Hu, Jinxiu Lei, Jinxiu Lei, Kui Zeng, Kui Zeng, Lushan Yu, Lushan Yu, Lushan Yu   +12 more
doaj   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Therapeutic potential of naturally derived carbon dots in sepsis-associated acute kidney injury

Chinese Medicine
Background Sepsis is a life-threatening infectious disease characterized by an uncontrolled inflammatory response and consequent multi-organ dysfunction.
Lei Wang, Zhong-Yao Li, Chong-Lei Zhong, Zi-Yang Teng, Bin Wang, Asma Rehman, Li-Wen Han, Ke-Wu Zeng, Ji-Guo Zhang, Zhi-Yuan Lu   +9 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Programmed enhancement of endogenous iron-mediated lysosomal membrane permeabilization for tumor ferroptosis/pyroptosis dual-induction

Nature Communications
Ferroptosis and pyroptosis, as emerging regulated forms of cell death capable of overcoming apoptotic resistance, demonstrate promising potential in tumor therapy. Given that iron manipulation and reactive oxygen species elevation serve as common stimuli
Luwen Zhu, Jiahao Hu, Xiaochuan Wu, Jucong Zhang, Xinyi Xu, Xiajie Huang, Bing Tian, Chun-Xia Zhao, Yongzhong Du, Liming Wu   +9 more
doaj   +1 more source

Sustained-release drug delivery systems

Eye
Abstract The design and development of a sustained-release drug delivery system targeting the administration of active pharmaceutical ingredients (APIs) to the eye could overcome the limitations of topically administered eye drops. Understanding how to modify or design new materials with specific functional properties that promote the ...
Rachel Williams, Helen Cauldbeck, Victoria Kearns   +2 more
openaire   +2 more sources

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Engineering Lipid Nanoparticles to Enhance Intracellular Delivery of Transforming Growth Factor-Beta siRNA (siTGF-β1) via Inhalation for Improving Pulmonary Fibrosis Post-Bleomycin Challenge

Pharmaceutics
Background/Objectives: Transforming Growth Factor-beta (TGFβ1) plays a core role in the process of pulmonary fibrosis (PF). The progression of pulmonary fibrosis can be alleviated by siRNA-based inhibiting TGF-β1.
Xu Deng, Yingjie Yang, Liming Gan, Xinliu Duan, Xiwei Wang, Jingyan Zhang, Aiping Wang, Anan Zhang, Zhizhao Yuan, Daquan Chen, Aiping Zheng   +10 more
doaj   +1 more source

Biodegradable implants for sustained drug release: Manufacturing considerations, drug stability, and drug release

Acta Ophthalmologica, 2017
SummaryPoly(D,L‐lactide‐co‐glycolide) (PLGA) is a biodegradable polymer used in preparing sustained release dosage forms including implants, microparticles, and nanoparticles. Indeed, an intravitreally injectable PLGA implant loaded with dexamethasone, an anti‐inflammatory corticosteroid, has been approved for treating retinal vein occlusion, posterior
openaire   +1 more source