Results 71 to 80 of about 3,939,397 (309)
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
, 2020 Approximately one third of newly discovered drug molecules show insufficient water solubility and therefore low oral bio-availability. Self-nano-emulsifying drug-delivery systems (SNEDDSs) are one of the emerging strategies developed to tackle the issues
Beloqui Garcia, Ana +7 more
core +1 more source
Materials & DesignMethicillin-resistant Staphylococcus aureus (MRSA), recognized for its resistance, poses a formidable challenge to public health, primarily attributable to its biochemical resistant mechanisms, capacity to form protective biofilms, and capacity to evade ...
Wenting Li +6 more
doaj +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Advances in Medical Devices for Augmented Acupuncture Therapy
Advanced ScienceAcupuncture, as a traditional medicine applied worldwide, is considered an effective treatment for numerous chronic diseases. Many researches have explored the biological mechanisms of acupuncture, including the skin‐neuro‐immune axis and inflammation ...
Ruisi Cai +7 more
doaj +1 more source
Development and validation of an HILIC/MS/MS method for determination of nusinersen in rabbit plasma
HeliyonA hydrophilic interaction liquid chromatography tandem mass spectrometry (HILIC/MS/MS) method was developed and validated for the quantitative analysis of the fully phosphorothioate modified oligonucleotide nusinersen.
Xiao Zhang +6 more
doaj +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Design, development and optimisation of veterinary intravaginal controlled release drug delivery systems [PDF]
, 2014 This Thesis begins by discussing the application of controlled drug delivery to the intravaginal delivery of hormones to control the oestrous cycle of farmed animals, with particular emphasis on the delivery of progestagens to cattle and sheep.
Ogle, Colin Roger
core
Sustained release injectables formed "in-situ" for veterinary use [PDF]
, 2006 Repetitive oral administration of tablets to companion animals is particularly challenging and there is a continuing need for alternative options such as long acting injections or implants.
Sautter, Caroline Anne Françoise
core +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source