Results 51 to 60 of about 3,939,397 (309)

Controlled Drug Release from Biodegradable Polymer Matrix Loaded in Microcontainers Using Hot Punching

, 2020
Microcontainers are reservoir-based advanced drug delivery systems (DDS) that have proven to increase the bioavailibity of the small-molecule drugs, targeting of biomolecules, protection of vaccines and improved treatment of Pseudomonas aeruginosa ...
Petersen, Ritika Singh, Keller, Stephan Sylvest, Tomas Rindzevicius, Anja Boisen, Rindzevicius, Tomas, Boisen, Anja, Line Hagner Nielsen, Stephan Sylvest Keller, Ritika Singh Petersen, Nielsen, Line Hagner   +9 more
core   +1 more source

SLC29A1 and SLC29A2 are human nicotinamide cell membrane transporters

Nature Communications
Nicotinamide (NAM), a main precursor of NAD+, is essential for cellular fuel respiration, energy production, and other cellular processes. Transporters for other precursors of NAD+ such as nicotinic acid and nicotinamide mononucleotide (NMN) have been ...
Mingyang Chen, Luexiang Yuan, Binxin Chen, Hui Chang, Jun Luo, Hengbin Zhang, Zhongjian Chen, Jiao Kong, Yaodong Yi, Mengru Bai, Minlei Dong, Hui Zhou, Huidi Jiang   +12 more
doaj   +1 more source

Stimuli-responsive structural transformation of adaptive peptide nanomaterials toward biomedical applications

Materials Today Bio
Self-assembling peptide nanomaterials have attracted widespread attention in the biomedical field due to their inherent advantages, such as programmable design, intrinsic bioactivity, and excellent biocompatibility.
Jikang Liu, Xunan Kan, Yong Su, Yao Yao, Jiawen Zhao, Jianwei Bao, Yong Jin, Qianli Zou   +7 more
doaj   +1 more source

Bone and Soft Tissue Neoplasms in Infants Versus Older Children: A Report From the Cancer in Young People in Canada Program

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background and Aims Infant bone and soft tissue neoplasms present distinct clinical challenges and lack large‐scale data to inform treatment decisions. This study aims to characterize bone and soft tissue neoplasms in infants in Canada and to compare their outcomes with those of older pediatric patients.
Samuel Sassine, Hallie Coltin, Maria Kondyli, Monia Marzouki, Nicolas Prud'homme, Nida Usmani, Rebecca J. Deyell, Lesleigh Abbott, Tony H. Truong, Sapna Oberoi, Ketan Kulkarni, Josée Brossard, Lynette Bowes, Paul Gibson, Sarah McKillop, Roona Sinha, Lillian Sung, Catherine Vezina, Laura Wheaton, Alexandra P. Zorzi, Marie‐Claude Pelland‐Marcotte, Thai Hoa Tran   +21 more
wiley   +1 more source

Lipid implants for controlled release of proteins [PDF]

, 2007
In recent years, we have seen significant progress towards understanding the role of proteins in both physiological and pathological processes. Especially neurotrophic factors have increasingly come into focus for the treatment of neurodegenerative ...
Könnings, Stephanie
core   +1 more source

Interaction of Alkannin with CPEB4 Contributes to Its Antitumor Effects in Melanoma

Biomolecules
Melanoma is a highly aggressive malignancy characterized by strong invasive and metastatic potential. CPEB4 has been implicated in melanoma progression and may serve as a potential therapeutic target.
Parwen Parhat, Min Li, Wenying Li, Jinyan Li, Mubarak Obulkasim, Yinglan Ma   +5 more
doaj   +1 more source

Impact of Initial Treatment Setting on Survival in Relapsed Pediatric and AYA Bone Sarcomas: A Secondary Analysis of a Prospective Clinical Trial

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Outcomes in relapsed or refractory pediatric and AYA bone sarcomas remain poor, and the impact of early referral to specialized sarcoma centers on survival is unclear. Early centralization of care may improve local and systemic treatment quality, but evidence in this population is limited.
Justyna Antoniuk‐Majchrzak, Katarzyna Bilska, Tomasz Koziński, Jadwiga Węcławek‐Tompol, Dorota Sega‐Pondel, Radosław Chaber, Wanda Badowska, Katarzyna Rosłan, Hanna Koseła‐Paterczyk, Anna Raciborska   +9 more
wiley   +1 more source

Effect of DFPP on Ferroptosis in Peripheral Blood CD14+ Monocytes of Hyperlipidemic Patients Involving the ACSL4/LPCAT3/ALOX5 Pathway

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Hyperlipidemia is a major risk factor for atherosclerotic cardiovascular disease (ASCVD). Although statins are the cornerstone of lipid‐lowering therapy, their use may be limited in some patients by adverse effects. This study evaluated the possible impact of non‐drug treatment using double‐filtration plasmapheresis (DFPP) on CD14+
Yun Cheng, Lan Li, Qingmei Yang, Meipeng Wu   +3 more
wiley   +1 more source

Measuring and locating the changes in protein structure using MELO

Nature Communications
Understanding the impact that subtle variations (missense mutation, environmental change, ion chelation, ligand binding, etc.) have on protein structure helps to reveal their biological effects, but remain extremely challenging due to the difficulty in ...
Lingyan Zheng, Yang Liao, Yintao Zhang, Mingxuan Liu, Mingkun Lu, Tingting Fu, Shuiyang Shi, Xiuna Sun, Chengbin Gu, Huaicheng Sun, Minjie Mou, Haibin Dai, Feng Zhu   +12 more
doaj   +1 more source

Study on the Physical Properties and Application of a Novel Pharmaceutical Excipient Made from Starch and Cellulose Co-Processing

Pharmaceuticals
Objective: This article investigated the structural characteristics, powder properties, and performance variations of co-processed pregelatinized starch (PS) and microcrystalline cellulose (MCC) at varying ratios.
Yong Bi, Hanfang Lei, Ying Fang, Simeng Wang, Jihui Tang   +4 more
doaj   +1 more source