Results 231 to 240 of about 3,939,397 (309)

AI comes to the Nobel Prize and drug discovery

Journal of Pharmaceutical Analysis
Ying Zhou, Yintao Zhang, Zhichao Zhang, Zhimeng Zhou, Feng Zhu   +4 more
doaj   +1 more source

Predicting early and complete drug release from long-acting injectables using explainable machine learning. [PDF]

Int J Pharm
Robles KN, Samad MD.
europepmc   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Real-time drug release monitoring from acoustically responsive scaffolds. [PDF]

Ultrason Sonochem
Spiekhout S, Abeid BA, Estrada JB, Fowlkes JB, Fabiilli ML, Aliabouzar M.   +5 more
europepmc   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Interpretable Two-Stage Machine Learning for Early and Full Drug Release Prediction in PLGA Microspheres. [PDF]

Pharmaceuticals (Basel)
Song Y, Bashyal S, Cho HJ, Woo MR, Kim JO, Hwang D.   +5 more
europepmc   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Controlled drug release and electroconductive performance of 3D printed scaffolds for neural tissue regeneration. [PDF]

J Mater Sci Mater Med
Oktay B, Ciftci F, Abdulazez IF, Bingol AB, Kose A, Erarslan A, Ustundag CB.   +6 more
europepmc   +1 more source

Comparative assessment of crystallographic and cryo‐EM models in the Protein Data Bank

FEBS Open Bio, EarlyView.
Raw data obtained by X‐ray crystallography or cryo‐EM result in experimental maps, ultimately fitted by atomic models. Although the physical principles are different, the final results can be viewed, compared, and evaluated in the same way. With cryogenic electron microscopy (cryo‐EM) on track to surpass X‐ray crystallography as the preferred method ...
Alexander Wlodawer, Pawel Rubach, Zbigniew Dauter, Wojciech Dec, Dariusz Brzezinski, Marta Kulik, Wladek Minor, Mariusz Jaskolski   +7 more
wiley   +1 more source

Paclitaxel-eluting silicone airway stent with sustained drug release and potent anti-fibrotic activity. [PDF]

Front Bioeng Biotechnol
Ding M, Song J, Zhao C, Yang X, Ouyang Y, Zhuo Z, Chen X, Zhu R, Wang X, Yu T, Tian X, Yang F.   +11 more
europepmc   +1 more source