Results 241 to 250 of about 3,939,397 (309)

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

Precision Temperature Control of Volume Phase Transition in Biocompatible PEG-Based Nanogels for Triggered Drug Release. [PDF]

ACS Nano Med
Patri S, Agrawal S, Kempen PJ, Thanh NTK, Kamaly N.   +4 more
europepmc   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Silk protein plastics for sustained and controlled drug release. [PDF]

Int J Pharm
Fajardo Cortes KA, Gordon EB, Arral ML, Abel A, Rivera J, Kaplan DL.   +5 more
europepmc   +1 more source

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

Structural color-based microneedle patch with NIR-triggered on-demand drug release for intelligent treatment of infected wounds. [PDF]

J Nanobiotechnology
Huang S, Yang M, Ding C, Du W, Yang S, Xi Q, Xiao F.   +6 more
europepmc   +1 more source

Selective elimination of quiescent cancer cells by dequalinium chloride via ROS‐mediated ferroptosis

FEBS Open Bio, EarlyView.
Dequalinium chloride (DQ) selectively eliminates quiescent cancer cells (QCCs) by amplifying mitochondrial ROS. QCCs exhibit elevated basal ROS and limited redox‐buffering capacity, making them vulnerable to further ROS increases. DQ‐induced ROS exceeds the tolerance threshold, triggering lipid peroxidation and ferroptosis, whereas proliferating cells ...
Kotaro Miyamoto, Shiori Sakai, Minori Endo, Terigele, Mizuho Niibori, Taiki Morita, Yu Goto, Arisa Yoshida, Tomohiro Tanaka, Ning Lin, Takahiro Kuchimaru, Hiroyuki Nakamura, Masahiro Inoue, Shinae Kizaka‐Kondoh, Tetsuya Kadonosono   +14 more
wiley   +1 more source

Self-Driven Drug Release Dual-Layer Dressing Composed of Electrospun Membrane and Hydrogel with Dynamic Structure Based on Piezoelectricity Transformation and Electrical Responsiveness. [PDF]

Polymers (Basel)
Wu Q, Zhao Y, Zhu W, Lv F, Si G.
europepmc   +1 more source

Preparation and Characterization of PCL/PEO-PVP ECM-Mimicking Coaxial Electrospun Membranes Loaded with Ciprofloxacin and Curcumin for Sequential Dual-Drug Release. [PDF]

Biomimetics (Basel)
Zhang H, Jiang F, Gao Q, Hu Q, Feng J.
europepmc   +1 more source

Selenium-Loaded Calcium Phosphate with Long-Term and Curative Dosage Drug Release for Post-Surgical Osteosarcoma Management and Osteogenesis. [PDF]

Int J Mol Sci
Yan Y, Chen Y, Meng D, Liu S, Wan Y, Xie Z, Xu D, Du C.   +7 more
europepmc   +1 more source