Results 111 to 120 of about 26,660 (305)

Macrophage‐targeted cerium‐tannic acid metal‐polyphenol framework nanoenzyme promotes in situ heart valves regeneration through adaptive immunomodulation

BMEMat, EarlyView.
A novel nanoenzyme based on cerium ions‐tannic acid metal‐polyphenol framework (FCT) has been developed and loaded onto DHVs for targeting M1 macrophages to reduce their ROS level and reprogram macrophage phenotype, thereby eliminating inflammation, promoting endothelialization and adaptive matrix remodeling of scaffolds, offering a promising strategy ...
Peng Song, Yunlong Wu, Xing Chen, Yafei Liu, Mengna Dong, Jiawei Shi, Xichi Wang, Nianguo Dong, Weihua Qiao, Qin Wang   +9 more
wiley   +1 more source

COMPUTATIONAL DRUG REPOSITIONING [PDF]

Biocomputing 2013, 2012
ZHIYONG LU, PANKAJ AGARWAL, ATUL J. BUTTE   +2 more
openaire   +1 more source

Artificial intelligence and machine learning‐assisted digital applications for biopharmaceutical manufacturing

Biotechnology Progress, EarlyView.
Abstract Artificial intelligence and automation are no longer just buzzwords in the biopharmaceutical industry. The manufacturing of a class of biologics, comprising monoclonal antibodies, cell therapies, and gene therapies, is far more complex than that of traditional small molecule drugs.
Shyam Panjwani, Hao Wei, John Mason
wiley   +1 more source

Chiari I Malformation: Review and Update of Current Treatment Options

Clinical Anatomy, EarlyView.
ABSTRACT The pathophysiology of Chiari malformation type I (CM‐I) is complex, involving structural abnormalities at the craniovertebral junction that result in herniation of the cerebellar tonsils through the foramen magnum. In this study, we aim to present and evaluate current treatment options for CM‐I, with a focus on evidence‐based clinical ...
Jordan J. Lo, Shuhei Shiino, Stephen Z. Shapiro, Brianna L. Hines, Noritaka Komune, Carmine Antonio Donofrio, Filippo Badaloni, Antonio Fioravanti, Joseph Lockwood, C. J. Bui, Aaron S. Dumont, R. Shane Tubbs   +11 more
wiley   +1 more source

A rare mental foramen variation and the role of cone‐beam computed tomography in preventing nerve injury: A case report

Clinical Advances in Periodontics, EarlyView.
Abstract Background The interforaminal space is frequently used for dental implant placement due to its strategic location between the bilateral mental foramina. However, neurosensory disturbances following surgical intervention near the mental foramen (MF) can occur in up to 43% of cases.
Magdalena Orlowska, Hend Abulatifa, Muhammad H. A. Saleh, Hom‐Lay Wang   +3 more
wiley   +1 more source

A successful periodontal‐orthodontic treatment of an advanced case of dental trauma in a 9‐year‐old patient: A case report with 16‐year follow‐up

Clinical Advances in Periodontics, EarlyView.
Abstract Background Traumatic dental injury (TDI) most often requires complex and interdisciplinary management. Several factors are associated with the success of TDI treatment, including proper treatment planning and periodontal maintenance. Methods The present 16‐year follow‐up report describes the interdisciplinary management of an extrusive ...
João Carnio, Maísa Casarin, João Kreling Carnio, Flavia Q. Pirih   +3 more
wiley   +1 more source

Learning Interpretable Disease Self-Representations for Drug Repositioning [PDF]

, 2019
Fabrizio Frasca, Diego Galeano, Guadalupe Gonzalez, Ivan Laponogov, Kirill Veselkov, Alberto Paccanaro, Michael M. Bronstein   +6 more
openalex   +1 more source

Dual Artery Compression for Patent Hemostasis and Prevention of Radial Artery Occlusion: The Quebec Terry2 Registry

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Radial artery occlusion (RAO) is a common complication following transradial artery access (TRA). Patent hemostasis is recommended to reduce RAO. Prophylactic ulnar artery compression is a technique to increase the rate of patent hemostasis.
Tomas A. Cieza, Francis Bonnenfant, Jimmy MacHaalany, Paola Ulacia‐Flores, Safia Ouarrak, Andres Ruhl, Erika Pomerleau, Joany Lapierre, Olivier F. Bertrand   +8 more
wiley   +1 more source

Excessive Ostial Stent Protrusion: Evaluation of Management Strategies and Clinical Outcomes of the Side Flap Technique

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Backgrounds Accurate stent positioning in aorto‐ostial lesions remains challenging due to complex three‐dimensional anatomy, lack of optimal fluoroscopic projections, and high rates of geographic miss. Stent overhang impairs guide catheter re‐engagement and complicates future revascularization.
Gregor Leibundgut, M. Bilal Iqbal, Claudiu Ungureanu, Anastasios Barmpas, Jasper Boeddinghaus, Teodor Buliga, Gabor G. Toth, Alexandru Achim   +7 more
wiley   +1 more source

Skeletal Editing from Pyridine to Aniline via C‐Insertion and N‐Isomerization

ChemistryEurope, EarlyView.
A concise protocol is presented that converts pyridines into anilines by externalizing the original pyridine nitrogen at either the "ipso" or "ortho" position, which results in para or meta‐primary aniline products. A key carbene‐insertion step precedes nitrogen migration, preserving both ring size and overall structure.
Yun Luo, Jing Dai, Yongchang Wei, Chang Min   +3 more
wiley   +1 more source