Results 171 to 180 of about 26,660 (305)

Targeting multiple conformations of SARS-CoV2 Papain-Like Protease for drug repositioning: An in-silico study

, 2021
Muhammad I. Ismail, Hanan M. Ragab, Adnan A. Bekhit, Tamer M. Ibrahim   +3 more
openalex   +2 more sources

Protecting Minors From Medical Malpractice Act: Implications for Otolaryngology–Head & Neck Surgery

The Laryngoscope, EarlyView.
Shiven Sharma, Margo K. McKenna, Julina Ongkasuwan, Michael J. Brenner   +3 more
wiley   +1 more source

Pharmacological Inhibition of APT2 by Solasonine Promotes Ferroptosis Through Palmitoylation Modulation in Gallbladder Cancer

Phytotherapy Research, EarlyView.
Schematic illustration of SS‐induced ferroptosis through targeting APT2‐mediated STAT3 palmitoylation in GBC cells. ABSTRACT Gallbladder cancer (GBC), the most prevalent and lethal biliary tract malignancy, lacks effective therapeutic strategies. Solasonine (SS), a bioactive steroidal alkaloid derived from Solanum nigrum L, exhibits antitumor activity ...
Liu‐qing Shi, Jing‐wei Zhao, Jia‐yun Zhu, Cheng Zhao, Zi‐yi Yang, Li‐jia Pan, Ben Ma, Zheng‐yu Chen, Zi‐ying Wang, Chun‐jie Li, Shi‐lei Liu, Jia‐wei Mei, Ping Dong   +12 more
wiley   +1 more source

Drug Repositioning for HPV Clade-Specific Cervicouterine Cancer Using the OCTAD Pipeline. [PDF]

Int J Mol Sci
Ruiz-Hernández J, Anda-Jáuregui G, Hernández-Lemus E.   +2 more
europepmc   +1 more source

Non-Negative Matrix Factorization for Drug Repositioning: Experiments with the repoDB Dataset.

, 2019
Gokhan Bakal, Halil Kilicoglu, Ramakanth Kavuluru   +2 more
openalex   +1 more source

Diurnal‐Only Foslevodopa/Foscarbidopa

Movement Disorders Clinical Practice, EarlyView.
Alexandra McGuckin, Yu‐Yan Poon, Galit Kleiner, Alfonso Fasano   +3 more
wiley   +1 more source

Farnesoid X receptor prevents hyperuricemia via activating ATP‐binding cassette subfamily G member 2

Rheumatology &Autoimmunity, EarlyView.
Farnesoid X receptor (FXR) activation reduces serum uric acid levels by upregulating the intestinal urate transporter ATP‐binding cassette subfamily G member 2 (ABCG2). These findings uncover a novel metabolic pathway for urate excretion and suggest that FXR agonists (e.g., obeticholic acid), represent a promising therapeutic strategy for the treatment
Rui Li, Guo Tang, Ye Yu, Guang‐Liang Chen, Liangjing Lu, Juan Wang   +5 more
wiley   +1 more source

Comparing isoflurane and desflurane: A prospective randomised blinded clinical trial in horses undergoing elective surgery

Veterinary Record, EarlyView.
Abstract Background The recovery period is associated with the greatest risk of injury for horses undergoing anaesthesia. Recovery quality and duration can be influenced by the volatile agent. Methods This prospective, randomised blinded clinical investigation recruited 101 healthy client‐owned horses undergoing elective surgery at one UK equine ...
Kate White, John Hird, Polly Taylor
wiley   +1 more source

Targeting Cancer Cell Energy Metabolism in Colorectal Cancer: Opportunities and Challenges from Drug Repositioning. [PDF]

Cells
Tomassini L, Pacifico T, Monteleone G, Stolfi C, Laudisi F.   +4 more
europepmc   +1 more source

A thermoplastic microfluidic platform with integrated electrospun scaffolds for assessing brain cell‐specific drug selectivity

VIEW, EarlyView.
Schematic representation of the microfluidic platform with its advantages. Abstract A major challenge in pharmacology is the limited selectivity of therapeutic compounds toward specific tissues or cells. Drugs often distribute systemically before reaching the intended site of action, affecting nontarget cells and potentially reducing efficacy or ...
Maria Testa, Laura Palumbo, Martina La Rosa, Antonella Girgenti, Fabio Salvatore Palumbo, Pasquale Picone, Francesco Lopresti, Domenico Nuzzo, Vincenzo La Carruba   +8 more
wiley   +1 more source