Results 281 to 290 of about 59,924 (341)

Improving drug repositioning with negative data labeling using large language models. [PDF]

J Cheminform
Picard M, Leclercq M, Bodein A, Scott-Boyer MP, Perin O, Droit A.   +5 more
europepmc   +1 more source

Making the Old New Again Through the Process of Recombinant Innovation

Journal of Product Innovation Management, EarlyView.
ABSTRACT Academic Summary Recombinant innovation—the process through which atypical and unexpected combinations of knowledge generate novel outcomes—is a critical driver of organizational distinctiveness and market transformation. While prior research has focused on firm‐ and industry‐level mechanisms, less attention has been given to multilevel ...
Vittoria Magrelli, Josip Kotlar, Alfredo De Massis, Federico Frattini, Antonio Messeni Petruzzelli   +4 more
wiley   +1 more source

Drug repositioning for pan-cancers of the digestive system: Identification of amonafide and BX795 as potential therapeutics via integrative Omics analysis. [PDF]

PLoS One
Liu W, Gao J, Ren S, Nashun B, Gao F.
europepmc   +1 more source

A BiO‐Optimizing Site Targeted (BOOST) Approach to Periodontal Regeneration Through Local Doxycycline Prior to Surgery: A Randomized Clinical Trial

Journal of Periodontal Research, EarlyView.
Localized pre‐surgical modulation of inflammation using doxycycline (BOOST) improved early wound healing and enhanced clinical and radiographic outcomes of periodontal regeneration at 1 year, demonstrating significant benefits in terms of CAL gain, defect fill, and pocket closure compared to standard care.
Mario Aimetti, Giacomo Baima, Virginia Lorenzetti, Nargiz Aliyeva, Mario Bottone, Giulia Maria Mariani, Federica Romano   +6 more
wiley   +1 more source

Soft Tissue Substitutes: Current Biomaterials and Indications at Teeth and Implant Sites

Journal of Periodontal Research, EarlyView.
This manuscript provides an updated overview of the current evidence on soft tissue graft substitutes for teeth and dental implants. When appropriately indicated, these biomaterials offer a reliable, less invasive alternative to autogenous grafts, effectively improving root coverage, keratinized mucosa width, and soft tissue thickness with reduced ...
Lorenzo Tavelli, Daniel Thoma, Maria Elisa Galarraga Vinueza, Mario Romandini, Shayan Barootchi   +4 more
wiley   +1 more source

Identifying novel therapeutic targets for non-alcoholic fatty liver disease using bioinformatics approaches: from drug repositioning to traditional Chinese medicine. [PDF]

Front Bioinform
Zhang J, Meng T, Gao W, Li X, Xu J.
europepmc   +1 more source

Effect of novel metabotropic glutamate receptor 5 antagonist on gastroesophageal reflux in dogs during anaesthesia

Journal of Small Animal Practice, EarlyView.
Objectives Gastroesophageal reflux during anaesthesia is a common event occurring in dogs with the potential to cause oesophageal injury and aspiration pneumonia. The objective of the current study was to evaluate the effect of the novel metabotropic glutamate receptor 5 antagonist TT001 on gastroesophageal reflux during anaesthesia in dogs using two ...
A. Glovéus, C. Ekstrand, A. Flöhr, S. Viskjer, O. Höglund   +4 more
wiley   +1 more source

Metformin and chloroquine enhanced the efficacy of cytarabine in acute lymphoblastic leukemia cell lines: a drug repositioning approach. [PDF]

Sci Rep
Poodeh AM, Sarab GA, Ravari MP, Najafzadeh M, Safarpour H, Zarban A, Sayadi M, Sajjadi SM.   +7 more
europepmc   +1 more source

Care of Older Adults as Nursing's Defining Ground: Leading the Transformation Toward Prevention‐Focused and Autonomy‐Promoting Healthcare Systems

Journal of Advanced Nursing, EarlyView.
José Manuel Hernández‐Padilla
wiley   +1 more source

In Silico Investigation of TATA-Binding Protein as a Therapeutic Target for Chagas Disease: Insights into FDA Drug Repositioning. [PDF]

Pharmaceuticals (Basel)
Gaona-López C, Méndez-Álvarez D, Gonzalez-Gonzalez A, Avalos-Navarro G, Paz-González AD, Moreno-Rodríguez A, Nogueda-Torres B, Rivera G.   +7 more
europepmc   +1 more source