Results 191 to 200 of about 3,896,424 (394)

Ubiquitination‐Driven Reprogramming of Proteostasis in Metastasis

Advanced Science, EarlyView.
The DCAF12–TRiC/CCT axis is a key regulator of metastasis in cancer. By reprogramming proteostasis to ensure efficient protein folding, it drives progression through a dual mechanism: enhancing cancer cell motility and invasiveness while concurrently activating pro‐growth and survival pathways.
Dongping Wei, Jiayan Chen, Yaping Xu
wiley   +1 more source

The future of pharmacology and therapeutics of the arachidonic acid cascade in the next decade: Innovative advancements in drug repurposing

Frontiers in Pharmacology
Many drugs can act on multiple targets or disease pathways, regardless of their original purpose. Drug repurposing involves reevaluating existing compounds for new medical uses. This can include repositioning approved drugs, redeveloping unapproved drugs,
Paola Patrignani, Paola Patrignani, Annalisa Contursi, Annalisa Contursi, Stefania Tacconelli, Stefania Tacconelli, Dieter Steinhilber   +6 more
doaj   +1 more source

Pharmacoepidemiology evaluation of bumetanide as a potential candidate for drug repurposing for Alzheimer's disease [PDF]

Jasmine Morales, Nico Gabriel, Loki Natarajan, Andrea Z. LaCroix, Aladdin H. Shadyab, Ronghui Xu, James D. Silverman, Howard Feldman, Inmaculada Hernandez   +8 more
openalex   +1 more source

Repurposing cholesterol lowering drugs in the treatment and management of monkeypox

, 2023
Saravanan Sekaran, Suresh Kumar R Sekar
openalex   +1 more source

Data science in unveiling COVID-19 pathogenesis and diagnosis: evolutionary origin to drug repurposing [PDF]

, 2020
Jayanta Kumar Das, Giuseppe Tradigo, Pierangelo Veltri, Pietro Hiram Guzzi, Swarup Roy   +4 more
openalex   +1 more source

What to Make and How to Make It: Combining Machine Learning and Statistical Learning to Design New Materials

Advanced Intelligent Discovery, EarlyView.
Combining machine learning and probabilistic statistical learning is a powerful way to discover and design new materials. A variety of machine learning approaches can be used to identify promising candidates for target applications, and causal inference can help identify potential ways to make them a reality.
Jonathan Y. C. Ting, Amanda S. Barnard
wiley   +1 more source

Review for "Bacitracin attenuates haemolysis‐induced insulin degradation during insulin sensitivity testing: Repurposing an old drug for use in metabolic research"

, 2020

openalex   +1 more source

Supplementary Tables 1 - 6, Figures 1 - 4 from Drug Repurposing for Gastrointestinal Stromal Tumor

, 2023
Ziyan Y. Pessetto, Scott J. Weir, Geetika Sethi, Melinda Broward, Andrew K. Godwin   +4 more
openalex   +2 more sources

Repurposed drugs and their progression against COVID-19 [PDF]

, 2021
Heena Rani, Simardeep Kaur, Rahul Sen, Mahesh Kumar Samota   +3 more
openalex   +1 more source

Artificial Intelligence for Bone: Theory, Methods, and Applications

Advanced Intelligent Discovery, EarlyView.
Advances in artificial intelligence (AI) offer the potential to improve bone research. The current review explores the contributions of AI to pathological study, biomarker discovery, drug design, and clinical diagnosis and prognosis of bone diseases. We envision that AI‐driven methodologies will enable identifying novel targets for drugs discovery. The
Dongfeng Yuan, Haicang Zhang, Liping Tong, Di Chen   +3 more
wiley   +1 more source