Results 181 to 190 of about 1,830,783 (287)

The cell-type specific interaction based drug repurposing for psychiatric disorders. [PDF]

Transl Psychiatry
Tang Y, Zhou Y, Wei Z, Wen Y, Peng C.
europepmc   +1 more source

Drug Repurposing durch Netzwerkmedizin

The dissertation seeks to improve drug research efficiency through drug repurposing, the exploration of new applications for existing drugs. The dissertation presents CoVex, designed for COVID-19, and NeDRex, a general platform for all drug repurposing ...
Sadegh, Sepideh
core  

A drug repurposing screen identifies antiviral compounds against Puumala Orthohantavirus. [PDF]

Sci Rep
Christ W, Porebski B, Fernandez-Capetillo O, Klingström J.   +3 more
europepmc   +1 more source

Activation of Metal Complexes With Ultrasound Waves for Targeted Anticancer Therapy

Angewandte Chemie International Edition, EarlyView.
Ultrasound enables non‐invasive activation of metal‐based therapeutics deep within tumors. Acoustic cavitation can drive sonodynamic reactive oxygen species generation or mechanochemical metal–ligand bond dissociation, enabling controlled release of bioactive payloads.
Félix Grosjean, Nicolás Montesdeoca, Gilles Berger, Johannes Karges   +3 more
wiley   +1 more source

A transcriptomics-based computational drug repurposing pipeline identifies simvastatin and primaquine as therapeutics for endometriosis. [PDF]

iScience
Oskotsky TT, Tang X, Arthurs E, Govil A, Abbasi F, Bhoja A, Bunis DG, Lau A, Einhaus J, Diop M, Irwin JC, Gaudilliere B, Stevenson DK, Giudice LC, McAllister SL, Sirota M.   +15 more
europepmc   +1 more source

Drug Repurposing as a Broad-Spectrum Strategy Against Coronaviruses: Frontiers in Mechanisms and Clinical Translation. [PDF]

Viruses
Du S, Wang Y, Liu C, Han Y, Zong R, Wang S, Du W, Yu L, Li Y.   +8 more
europepmc   +1 more source

In Silico to In Cerebro—Development of the Orexin Receptor Antagonist “Photorexant” for Photomodulation In Vitro and in Mouse Brains

Angewandte Chemie International Edition, EarlyView.
Following a structure‐based design approach, photoswitchable derivatives of the FDA‐approved drug suvorexant were designed, docked, synthesized, and characterized pharmacologically at the orexin 1 and 2 receptors (OX1R and OX2R). Optimized “photorexant” showed up to an 11‐fold difference in IC50 between photoisomers, enabled dynamic and reversible ...
Marcus Angermann, Marie H. Deventer, Vicente Ledesma‐Martin, Nuno Martinho, Alix Flake, Silvia Mori, Angel Nuñez, Jaime Pignatelli, Rita C. Guedes, Christophe P. Stove, Michael Decker   +10 more
wiley   +1 more source

Pharmacogenomic Stratification for Oncology Drug Repurposing: An Exposure Target Context Eligibility Framework. [PDF]

Pharmaceuticals (Basel)
El-Tanani M, Wali AF, Rabbani SA, El-Tanani Y, Rangraze I, Muhana F.   +5 more
europepmc   +1 more source

Human evolution and the obstetrical dilemma: The pelvic floor hypothesis

The Anatomical Record, EarlyView.
Abstract Human childbirth is mechanically difficult because a large‐headed, broad‐shouldered fetus must pass through a comparatively narrow, twisted bony birth canal. Traditional explanations of this “obstetrical dilemma” emphasize the role of bipedal locomotion in inhibiting the evolution of a wider, more spacious pelvis.
Barbara Fischer, Ekaterina Stansfield
wiley   +1 more source

G2DR: a genotype-first framework for genetics-informed target prioritization and drug repurposing. [PDF]

Brief Bioinform
Muneeb M, Ascher DB.
europepmc   +1 more source