Results 161 to 170 of about 1,830,783 (287)

Computational drug repurposing: approaches, evaluation of in silico resources and case studies

521542Repurposing of existing drugs for new indications has attracted substantial attention owing to its potential to accelerate drug development and reduce costs.
Beccari, Andrea Rosario, García-Serna, Ricard, Aittokallio, Tero, Fratelli, Maddalena, Ballante, Flavio, Kort, Martin de, Tanoli, Ziaurrehman, Wennerberg, Krister, Kalman, Adelinn, Cabri, Enrico, Mestres, Jordi, Vähä-Koskela, Markus, Carreras-Puigvert, Jordi, Costantini, Susan, Tanoli, Ziaurrehman Ur Rehman, Xhaard, Henri, Saunders, Gary, Budillon, Alfredo D.O., Ussi, Anton E., Polo, Andrea, Fernández-Torras, Adrià, Gadiya, Yojana, Benfenati, Emilio B., Fiorenza, Laura, Budillon, Alfredo, Seemab, Umair, Tampere, Marianna, Aittokallio, Tero A., Ianevski, Aleksandr, Miihkinen, Mitro, Talarico, Carmine, Nader, Kristen Michelle, Özcan, Umut Onur, Schaal, Wesley, Potdar, Swapnil, Lo, Donald C., Seashore-Ludlow, Brinton A., Spjuth, Ola, Jacobs, Marc, Östling, Päivi, Gribbon, Philip, Garcia, Ismael Gomez, Fratelli, Maddalena M., Gómez García, Ismael, Kushnir, Aleksandr, Saarela, Jani S., Quintana, Jordi, Seashore-Ludlow, Brinton, Leinonen, Henri, Saunders, Gary Ian, Leinonen, Henri O., Benfenati, Emilio, de Kort, Martin, Saarela, Jani   +53 more
core   +1 more source

Artificial Intelligence‐Driven Network Pharmacology: A Methodological Paradigm Shift Bridging Traditional Wisdom and Modern Science

Advanced Intelligent Discovery, EarlyView.
Artificial intelligence is redefining network pharmacology (NP). By integrating knowledge graph engineering, geometric deep learning, multiomics anchoring, and generative reasoning, AI‐driven NP (AI‐NP) transforms static target mapping into dynamic, predictive modeling.
Cong Wang, Sile Hu, Rigahai Ji, Riguna A, Siqige Hao, Ma Zhuo, Yi‐Hung Chen, Bisihalatu Hu, Ulana Bai, Xigui Hada   +9 more
wiley   +1 more source

SOLiD‐MaP: A Photoproximity Labeling Platform for Small Molecule Binding Site Mapping on RNA

Angewandte Chemie, EarlyView.
SOLiD‐MaP is a ligand‐directed photoproximity labeling strategy developed for RNA binding‐site analysis. Singlet oxygen‐mediated labeling creates a proximity‐dependent chemical footprint of bound small molecules on RNA. Coupling this chemistry with mutational profiling enables identification of the ligand‐binding region at nucleotide resolution ...
Lin L. Rietveld, Wei Wu, Filip M. Zawisza, Danny Incarnato, Zeshi Li   +4 more
wiley   +2 more sources

Drug Repurposing as an Effective Drug Discovery Strategy: A Critical Review

Drug Design, Development and Therapy
Abdulaziz H Al Khzem,1 Saad M Wali2 1Department of Pharmaceutical Chemistry, College of Pharmacy, Imam Abdulrahman Bin Faisal University, Dammam, 31441, Eastern Province, Kingdom of Saudi Arabia; 2Pharmacology and Toxicology Department, College of ...
Al Khzem AH, Wali SM
doaj  

Ceftriaxone's Multifaceted Neuroprotection in Parkinson's Disease: Preclinical Evidence and Implications for Drug Repurposing. [PDF]

Drug Des Devel Ther
Wen P, Dou L, Yang X, Han D, Wang J, Wu H, Ren C.   +6 more
europepmc   +1 more source

Therapy for Myhre Syndrome: Goals, Misconceptions, and Current Agents

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Myhre Syndrome (MYHRS, MIM #139210) is a rare, multisystem connective tissue disorder caused by recurrent heterozygous gain‐of‐function pathogenic variants in the SMAD4 gene, a key player in TGF‐β signaling and a regulator of extracellular matrix homeostasis.
Alessandro De Falco, Alfonso Manuel D'Alessio, Nicola Brunetti‐Pierri   +2 more
wiley   +1 more source

Cobalt‐Catalyzed C─N Bond Formation via Metal‐Hydride Hydrogen Atom Transfer (MHAT)

Angewandte Chemie, EarlyView.
Cobalt‐catalyzed metal‐hydride hydrogen atom transfer (Co‐MHAT) converts simple alkenes into C─N bonds under mild, near‐neutral conditions. A shared Co─H‐initiated radical/organocobalt intermediate is channeled into radical trapping, radical‐polar crossover, or radical ligand transfer, unifying hydroamination, hydroazidation, hydroamidation, and remote
Arman Khosravi, Ming‐Yu Ngai
wiley   +2 more sources

Leveraging neural network models for drug repurposing: a case study on cardiac hypertrophy. [PDF]

Sci Rep
Magnusson R, Johansson M, Hagvall S, Synnergren J.   +3 more
europepmc   +1 more source

Review of the Molecular and Developmental Basis of Myhre Syndrome, Bench Research

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Myhre syndrome (MS) is a connective‐tissue disorder within the acromelic dysplasia spectrum. It is characterized by congenital craniofacial, skeletal, cutaneous anomalies, respiratory, cardiovascular along with intellectual disability, deafness, and progressive fibrosis.
Camille Viaut, Valerie Cormier‐Daire
wiley   +1 more source

Exploring drug repurposing for monkeypox virus: A structural and computational approach. [PDF]

J Taibah Univ Med Sci
Gul S, Akhtar F, Rehman I, Shah M, Rashid U, Rauf A.   +5 more
europepmc   +1 more source