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Drug Repurposing

Proceedings of the 8th International Conference on Computational Systems-Biology and Bioinformatics, 2017
In the search of safer and more effective drugs while reducing costs and increasing productivity of novel drug discovery, scientists are changing their focus to an approach known as drug repurposing. This involves finding a new therapeutic effect of an already existing drug.
Eva Rahman Kabir, Mohammad Kawsar Sharif Siam, Sanam Madihah Kabir, Arafat Khan, Samiul Alam Rajib   +4 more
openaire   +1 more source

Drug repurposing for viral cancers: A paradigm of machine learning, deep learning, and virtual screening‐based approaches

Journal of Medical Virology, 2023
Cancer management is major concern of health organizations and viral cancers account for approximately 15.4% of all known human cancers. Due to large number of patients, efficient treatments for viral cancers are needed.
Faheem Ahmed, In Suk Kang, K. Kim, A. Asif, Chethikkattuveli Salih Abdul Rahim, A. Samantasinghar, F. H. Memon, Kyung-Hyun Choi   +7 more
semanticscholar   +1 more source

repurposing drugs

2023
This data set examines the practice of repurposing drugs for multiple therapeutic purposes, which is a persistent 'innovation' strategy in the pharmaceutical industry.
openaire   +1 more source

Drug repurposing for Alzheimer’s disease and other neurodegenerative disorders

Nature Communications
Repurposed drugs provide a rich source of potential therapies for Alzheimer’s disease (AD) and other neurodegenerative disorders (NDD). Repurposed drugs have information from non-clinical studies, phase 1 dosing, and safety and tolerability data ...
Jeffrey L. Cummings, Yadi Zhou, Alexandra Van Stone, D. Cammann, R. Tonegawa-Kuji, Jorge Fonseca, Feixiong Cheng   +6 more
semanticscholar   +1 more source

The discovery of novel antivirals for the treatment of mpox: is drug repurposing the answer?

Expert Opinion on Drug Discovery, 2023
Introduction Drugs that have demonstrated good activity against any member of the Orthopoxvirus genus are good candidates for repurposing studies against the mpox virus (MPXV).
Ahmed A. Ezat, J. M. Abduljalil, Ahmed M. Elghareib, A. Samir, Abdo A. Elfiky   +4 more
semanticscholar   +1 more source

Purposeful Drug Repurposing

JAMA Psychiatry
This Viewpoint discusses a proposal to identify candidates for drug repurposing and allocate US Food and Drug Administration funds to cover the cost of evaluating and approving such drugs for their novel indications.
Peter, Nagele, Charles R, Conway, Charles F, Zorumski   +2 more
openaire   +2 more sources

MRNDR: Multihead Attention-Based Recommendation Network for Drug Repurposing

Journal of Chemical Information and Modeling
As is well-known, the process of developing new drugs is extremely expensive, whereas drug repurposing represents a promising approach to augment the efficiency of new drug development.
Xin Feng, Zhansen Ma, Cuinan Yu, Ruihao Xin   +3 more
semanticscholar   +1 more source

Identification of LRRK2 Inhibitors through Computational Drug Repurposing.

ACS Chemical Neuroscience, 2023
Parkinson's disease (PD) is the second most common neurodegenerative disorder that affects more than ten million people worldwide. However, the current PD treatments are still limited and alternative treatment strategies are urgently required.
Shuoyan Tan, Ruiqiang Lu, Dahong Yao, Jun Wang, Peng Gao, Guotong Xie, Huanxiang Liu, X. Yao   +7 more
semanticscholar   +1 more source

Repurposed Drugs

Journal of Prescribing Practice
In this month's article, George Winter discusses the potential for repurposed drugs to change the therapeutic landscape
Duilio Cervantes, Aida Adlimoghaddam
openaire   +2 more sources

Drug Repurposing: A Leading Strategy for New Threats and Targets.

ACS Pharmacology & Translational Science
Less than 6% of rare illnesses have an appropriate treatment option. Repurposed medications for new indications are a cost-effective and time-saving strategy that results in excellent success rates, which may significantly lower the risk associated with ...
Ashish Sriram Mishra, Manimaran Vasanthan, S. P. Malliappan   +2 more
semanticscholar   +1 more source