Results 291 to 300 of about 3,896,424 (394)

Advancing Medulloblastoma Treatment: Molecular Mechanisms, Drug Repurposing, and Precision Therapies. [PDF]

Mol Diagn Ther
Abdel-Rasol MA, El-Sayed WM.
europepmc   +1 more source

Drug repurposing for COVID-19 using graph neural network and harmonizing multiple evidence.

, 2022
Kang‐Lin Hsieh, Yinyin Wang, Luyao Chen, Zhongming Zhao, Sean I. Savitz, Xiaoqian Jiang, Jing Tang, Yejin Kim   +7 more
openalex   +1 more source

Artificial intelligence in preclinical epilepsy research: Current state, potential, and challenges

Epilepsia Open, EarlyView.
Abstract Preclinical translational epilepsy research uses animal models to better understand the mechanisms underlying epilepsy and its comorbidities, as well as to analyze and develop potential treatments that may mitigate this neurological disorder and its associated conditions. Artificial intelligence (AI) has emerged as a transformative tool across
Jesús Servando Medel‐Matus, Cesar Santana‐Gomez, Ruby G. Escalante, Dominique Duncan, Pedro F. Viana, Giulia Sofia Cereda, Naoto Kuroda, Aristea S. Galanopoulou   +7 more
wiley   +1 more source

Statins as Antifungal Agents: A Review on Drug Repurposing and Nanotechnology-Driven Delivery Strategies. [PDF]

Fundam Clin Pharmacol
E Silva DM, de Souza Lacerda L, de Souza Andrioli A, Braz WR, Campos LM, de Paiva MRB, Pittella F, Fabri RL, Tavares GD.   +8 more
europepmc   +1 more source

Areas of research priorities in epilepsy: A position paper of the European Reference Network for Rare and Complex Epilepsies, EpiCARE

Epilepsia Open, EarlyView.
Abstract Objective To define and articulate research priorities in epilepsy identified by the European Reference Network for Rare and Complex Epilepsies (ERN EpiCARE), addressing key unmet needs across the spectrum of rare and complex epilepsies. Methods This position paper was developed through a structured collaborative process involving patient ...
Sébile Tchaicha, Stéphane Auvin, Sándor Beniczky, Andreas Brunklaus, Lieven Lagae, Emilio Perucca, Rainer Surges, Sophie Adler, Christoph Helmstaedter, Floor Jansen, Guido Rubboli, Philippe Ryvlin, Nicola Specchio, Eugen Trinka, Ingmar Blümcke, Valentina de Giorgis, Katarzyna Kotulska, Gaetan Lesca, Masa Malenica, Amy McTague, Rima Nabbout, Rikke Steensbjerre Møller, Sandra Silva Arrieta, Isabella Brambilla, Małgorzata Kosla, Kees Braun, J. Helen Cross, Alexis Arzimanoglou   +27 more
wiley   +1 more source

Discovery of drug candidate to inhibit bronchogenic carcinoma genes biomarkers based on drug repurposing. [PDF]

Discov Oncol
Khalvati B, Kavousi K, Behmard E, Keyhanipour AH, Arabfard M.   +4 more
europepmc   +1 more source

Cytotoxicity of 19 Pesticides in Rainbow Trout Gill, Liver, and Intestinal Cell Lines

Environmental Toxicology and Chemistry, EarlyView.
Abstract The rainbow trout gill cell line (RTgill‐W1), via test guideline 249 of the Organisation for Economic Co‐operation and Development, has been established as a promising New Approach Methodology, although to advance confidence in the method more case studies are needed that: 1) expand our understanding of applicability domains (chemicals with ...
Sophie Emberley‐Korkmaz, Krittika Mittal, Na'im Temlock, Jessica Head, Niladri Basu   +4 more
wiley   +1 more source

Drug Repurposing for Targeting Cancer Stem-like Cells in Glioblastoma. [PDF]

Cancers (Basel)
De Sousa-Coelho AL, Solaković B, Bento AD, Fernandes MT.   +3 more
europepmc   +1 more source

Current Advancements of Probiotic Foods and Their Role in Sustainable Food Security

Food Bioengineering, EarlyView.
ABSTRACT Probiotic foods have evolved from traditional fermented products to scientifically validated functional foods, defined by the FAO and WHO as live microorganism that confer a health benefit on the host when administered in adequate amounts, with effects being strain, does and end point specific.
Ashenafi Teklay Yaekob, Gebremedhin Gebreslassie, Etsay Mesele, Tesfakiros Semere   +3 more
wiley   +1 more source

Integrated screening for small molecules interfering with PKM2: a drug repurposing strategy against glioblastoma. [PDF]

J Transl Med
Costantini S, Romeo I, Fanelli G, Roca MS, Gualtieri G, Bagnara P, Polo A, Di Gennaro E, Ortuso F, Alcaro S, Budillon A, Ciliberto G, Paggi MG, Abbruzzese C.   +13 more
europepmc   +1 more source