Results 241 to 250 of about 2,335,473 (307)

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Occurrence of tetracycline residues in cattle manure from southern Malawi: implications for antimicrobial resistance and One Health

Kapalamula T, Masitala P, Mwenda N, Chatanga E, Nambala P, Mkakosya R, Manning S.   +6 more
europepmc   +1 more source

Texture Analyzer-Derived SeDeM-ODT Extension for Bisoprolol Fumarate Orodispersible Tablets: Formulation Discrimination Within a Pharmacopoeial Disintegration-Compliant Space. [PDF]

Pharmaceutics
Afşin Ç, Şahbaz S, Özer-Önder S, Uğurlu T.   +3 more
europepmc   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

Integrative In Silico Profiling of Major Phytochemicals From a Sclerocarya birrea-Nauclea latifolia-Piper longum Mixture: Docking, Molecular Dynamics, ADMET, and Ligand-Based Target Prediction on Shared Pathways in Type 2 Diabetes Mellitus and Alzheimer's Disease. [PDF]

ChemistryOpen
Tientcheu JPD, İstifli ES.
europepmc   +1 more source

Harnessing snake venom cardiotoxins for antimicrobial peptide discovery. [PDF]

NPJ Drug Discov
Mendes B, Almeida JR, Castelletto V, Hamley IW, Barrett G.   +4 more
europepmc   +1 more source

CMA-DTI: a cross-modal fusion and attentive interaction network for interpretable drug-target interaction prediction. [PDF]

Front Bioinform
Qin C, Zheng D, Wang Z, Li Y, Cao J, Qiu H, Kan H, Sun L, Liu Y, Hu J.   +9 more
europepmc   +1 more source

Insights on the Generation of Polymeric Drug Carriers via Supercritical Fluid-Assisted Technologies. [PDF]

Materials (Basel)
Zanotti A, Cardea S.
europepmc   +1 more source

Phospholipid-Prednisolone Conjugates for Targeted IBD Therapy: Structural Design, Synthetic Approaches, Optimization, and Computational Evaluation. [PDF]

Molecules
Ifrah S, Jabarin A, Yarmolinsky L, Cohen-Hagai K, Deutsch M, Dahan A, Ben-Shabat S.   +6 more
europepmc   +1 more source

Secondary-Amine Relay Enables Lysine-Directed Multicomponent Functionalization of Peptides. [PDF]

JACS Au
Ren C, Zhang M, Jiang T, Wan F, Lv Y, Yang L, Li C.   +6 more
europepmc   +1 more source