Results 111 to 120 of about 377,494 (308)

Blocking the Hemagglutinin of Influenza A Virus by Multivalent Inhibitors [PDF]

, 2019
The aim of this thesis is to develop multivalent carbohydrate-based ligands as inhibitors of the adhesion of the Influenza A virus (IAV). The adhesion protein hemagglutinin (HA) plays a central role in the infection process, and has potential as a drug ...
Afd Chemical Biology and Drug Discovery, Chemical Biology and Drug Discovery, Lu, Wenjing   +2 more
core  

Can we cook away veterinary drug residues in food? [PDF]

, 2014
When most people think of food safety they think of food poisoning and bacteria. They also, one hopes, generally follow the well-understood public advice on bacterial risks and store their food properly and cook it thoroughly.
Cooper, Kevin, Gadaj, Anna
core   +2 more sources

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Polysaccharide drug delivery systems based on pectin and chitosan [PDF]

, 2010
Chitosans and pectins are natural polysaccharides which show great potential in drug delivery systems. Chitosans are a family of strongly polycationic derivatives of poly-N-acetyl-D-glucosamine.
Kok, M. S., Adams, G. G., Morris, Gordon, Harding, S. E.   +3 more
core  

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Surveillance of veterinary drug residues in pork meat, Madagascar [PDF]

, 2013
Antibiotics are used in animal feeds as growth promoters or for disease prevention and treatment. Drugs and metabolites are accumulated into body cells and are known as drug residue.
Pognon, Damien, Randriamparany, Tantely, Porphyre, Vincent, Rakotoharinome, Vincent Michel, Cardinale, Eric, Chane Ming, Jimmy, Idoumbin, Jean-Patrick   +6 more
core  

Correction: Antimicrobial resistance and molecular typing of Salmonella in the chicken production chain in Hubei Province, China

Animal Diseases, 2023
Cuirong Wu, Lihui Liu, Yuxin Sui, Lulu Huang, Yang Chen, Haihong Hao, Yuanhu Pan, Zhenli Liu, Guyue Cheng   +8 more
doaj   +1 more source

Preparation and interaction mechanism analysis of single-chain fragment variables against phenylethanolamine A

Animal Diseases
This is the first report on the screening, expression, and recognition mechanism analysis of single-chain fragment variable (scFv) against phenylethanolamine A (PEAA), a newly emerged β-adrenergic agonist illegally used as a feed additive for growth ...
Long Li, Ren Hou, Huaming Li, Shiyun Han, Jixiang Liang, Yu Si, Dapeng Peng   +6 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source