Results 31 to 40 of about 629,459 (301)
Phage Products for Fighting Antimicrobial Resistance
Microorganisms, 2022 Antimicrobial resistance (AMR) has become a global public health issue and antibiotic agents have lagged behind the rise in bacterial resistance. We are searching for a new method to combat AMR and phages are viruses that can effectively fight bacterial ...
Yuanling Huang +6 more
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Hot-spot analysis for drug discovery targeting protein-protein interactions [PDF]
, 2018 Introduction: Protein-protein interactions are important for biological processes and pathological situations, and are attractive targets for drug discovery. However, rational drug design targeting protein-protein interactions is still highly challenging.
Fernández-Recio, Juan, Rosell, Mireia
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Drug Delivery, 2022 In order to solve the difficulties in the treatment of Staphylococcus aureus infections, a novel enrofloxacin-cyclodextrin (β-CD) inclusion complexes (IC) containing hyaluronic acid/chitosan (HA/CS) self-assemble composite nanosystems covered by ...
Zhiwei Liang, Dongmei Chen
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Structural Prediction of Protein–Protein Interactions by Docking: Application to Biomedical Problems [PDF]
, 2018 A huge amount of genetic information is available thanks to the recent advances in sequencing technologies and the larger computational capabilities, but the interpretation of such genetic data at phenotypic level remains elusive.
Barradas-Bautista, Didier +3 more
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Advance in strategies to build efficient vaccines against tuberculosis
Frontiers in Veterinary Science, 2022 Tuberculosis is a chronic consumptive infectious disease, which can cause great damage to human and animal health all over the world. The emergence of multi-drug resistant strains, the unstable protective effect of Bacillus Calmette-Guérin (BCG) vaccine ...
Wei Qu +9 more
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The role of pharmacokinetics in veterinary drug residues [PDF]
Drug Testing and Analysis, 2012 This review provides a summary of those pharmacokinetic properties of veterinary drugs relevant to marker residues, marker tissues, and residue depletion rates. The scientific literature in this field is very extensive and there is also a wealth of data available on the websites of various regulatory jurisdictions.
Lees, Peter, Toutain, Pierre-Louis
openaire +5 more sources
Mapping the druggable allosteric space of G-protein coupled receptors: a fragment-based molecular dynamics approach. [PDF]
, 2010 To address the problem of specificity in G-protein coupled receptor (GPCR) drug discovery, there has been tremendous recent interest in allosteric drugs that bind at sites topographically distinct from the orthosteric site. Unfortunately, structure-based
Ivetac, Anthony, McCammon, J Andrew
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Pharmacokinetic and Pharmacodynamic Drug–Drug Interactions: Research Methods and Applications
Metabolites, 2023 Because of the high research and development cost of new drugs, the long development process of new drugs, and the high failure rate at later stages, combining past drugs has gradually become a more economical and attractive alternative.
Lei Sun +7 more
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Influenza A nucleoprotein binding sites for antivirals: current research and future potential [PDF]
, 2014 This document is the Accepted Manuscript version of the following article: Andreas Kukol and Hershna Patel, ‘Influenza A nucleoprotein binding sites for antivirals: current research and future potential’, Future Biology, Vol 9(7): 625-627, July 2014. The
Kukol, A, Kukol, A, Patel, H., Patel, H.
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Preparation, characterization and pharmacokinetics of cyadox nanosuspension
Scientific Reports, 2017 An increase in number of newly developed synthetic drugs displays bioavailability constraints because of poor water solubility. Nanosuspensions formulation may help to overwhelm these problems by increasing dissolution velocity and saturation solubility.
Adeel Sattar +8 more
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