Results 71 to 80 of about 592,323 (309)

History of antibiotic adaptation influences microbial evolutionary dynamics during subsequent treatment.

PLoS Biology, 2017
Antibiotic regimens often include the sequential changing of drugs to limit the development and evolution of resistance of bacterial pathogens. It remains unclear how history of adaptation to one antibiotic can influence the resistance profiles when ...
Phillip Yen, Jason A Papin
doaj   +1 more source

Overcoming the challenges of cancer drug resistance through bacterial-mediated therapy. [PDF]

, 2019
Despite tremendous efforts to fight cancer, it remains a major public health problem and a leading cause of death worldwide. With increased knowledge of cancer pathways and improved technological platforms, precision therapeutics that specifically target
Bivona, Trever G, Chang, Samantha, Hernández, Amanda C, Keasling, Jay D, Kothari, Ankita, Mao, Jian-Hua, Snijders, Antoine M, Wang, Jessica, Zargar, Amin   +8 more
core   +1 more source

Role of xenobiotic transporters in bacterial drug resistance and virulence [PDF]

IUBMB Life, 2008
AbstractSince the discovery of antibiotic therapeutics, the battles between humans and infectious diseases have never been stopped. Humans always face the appearance of a new bacterial drug‐resistant strain followed by new antibiotic development. However, as the genome sequences of infectious bacteria have been gradually determined, a completely new ...
Kunihiko, Nishino, Akihito, Yamaguchi
openaire   +2 more sources

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Origin and Proliferation of Multiple-Drug Resistance in Bacterial Pathogens [PDF]

Microbiology and Molecular Biology Reviews, 2015
SUMMARY Many studies report the high prevalence of multiply drug-resistant (MDR) strains. Because MDR infections are often significantly harder and more expensive to treat, they represent a growing public health threat. However, for different pathogens, different underlying mechanisms are traditionally used to explain these observations, and ...
Chang, Hsiao-Han, Cohen, Ted, Grad, Yonatan, Hanage, William, O, Thomas F., Lipsitch, Marc   +5 more
openaire   +3 more sources

Understanding bio‐based polymers: A study of origins, properties, biodegradation and their impact on health and the environment

FEBS Open Bio, EarlyView.
This review provides an overview of bio‐based polymer sources, their unique functional properties and their environmental impact, and addresses their role as sustainable alternatives. It discusses end‐of‐life options, including composting and anaerobic digestion for renewable energy.
Sabina Kolbl Repinc, Blaž Stres, Mirica Karlovits, Igor Karlovits, Petra Jerič, Ondrej Panák, Anja Verbič, Blaž Likozar, Uroš Novak   +8 more
wiley   +1 more source

Adenosine Monophosphate as a Metabolic Adjuvant Enhances Antibiotic Efficacy against Drug-Resistant Bacterial Pathogens

Pharmaceuticals
Global bacterial infections are on the rise, and drug resistance to bacteria is gradually rendering existing antibiotics ineffective. Therefore, the discovery of new strategies is urgently needed.
Wenxuan Zhang, Zhenyi Wu, Zulifukeer Maituersong, Ting Wang, Yubin Su   +4 more
doaj   +1 more source

Relapsing–Remitting Multiple Sclerosis Is Associated With a Dysbiotic Oral Microbiome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by inflammation, demyelination, and neurological impairment. While the gut microbiota's role in MS is extensively studied, the association between the oral microbiota and MS remains underexplored, particularly in North American cohorts.
Sukirth M. Ganesan, Meeta Yadav, Sudeep Ghimire, Peter C. Lehman, Apurva J. Patel, Sydney Woods, Heena Olalde, Jemmie Hoang, Mishelle Paullus, Catherine Cherwin, Christine Gill, Tracey Cho, Ashutosh K. Mangalam   +12 more
wiley   +1 more source

An evaluation of methods to assess the effect of antimicrobial residues on the human gut flora [PDF]

, 1993
1. Barrier effect. Relevant models should include an anaerobic dominant flora that antagonizes minor bacterial populations such as drug resistant E. coli. 2. Anaerobes vs. aerobes.
Corpet, Denis E.
core   +2 more sources

Exploring the evidence base for national and regional policy interventions to combat resistance [PDF]

, 2015
The effectiveness of existing policies to control antimicrobial resistance is not yet fully understood. A strengthened evidence base is needed to inform effective policy interventions across countries with different income levels and the human health and
Aarestrup, Aarestrup, Ahuja, Aidara-Kane, Alimuddin Zumla, Allegranzi, Allegranzi, Amábile-Cuevas, Anthony D So, Anthony Kessel, Baertlein, Belongia, Belongia, Bushnell, Catley, Catley, Cheng, Coenen, Crowther-Gibson, Dagan, Datema, Davey, David L Heymann, De Boeck, Earnshaw, Emmeline J Buckley, Fazal K Dar, Finkelstein, Fätkenheuer, Gerber, Govin Permanand, Grave, Grave, Grazia Caleo, Grundmann, Hammerum, Hanne Bak Pedersen, Harbarth, Haydar Giha, Hennessy, Henry Lishi Li, Heuer, Holloway, Huttner, Huttner, Jack, Jasper Littmann, John-Arne Røttingen, Jørgen Schlundt, Kariuki, Katakweba, Khalid M Bindayna, Khan, Komolafe, Kümmerer, Little, Luoto, Mandal, Mark Rweyemamu, Marti, McNulty, Mishal Khan, Mitj, Mohammed Shahid, Moyane, Mshana, Nisi, Ogan, Okeke, Okeke, Okeke, Osman A Dar, Parry, Pittet, Pletz, Radley, Ranji, Richard Kock, Rumina Hasan, Silverman, Simonsen, Song, Speksnijder, Spurling, Stephan Harbarth, Vanden Eng, Vernet, Versporten, Versporten, Viberg, Vlieghe, Walt, Xiao, Zingg   +93 more
core   +2 more sources