Results 251 to 260 of about 361,408 (311)
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Drug repurposing to overcome microbial resistance
Drug Discovery Today, 2022Infections are a growing global threat, and the number of resistant species of microbial pathogens is alarming. However, the rapid development of cross-resistant or multidrug-resistant strains and the development of so-called 'superbugs' are in stark contrast to the number of newly launched anti-infectives on the market. In this review, I summarize the
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1955
Publisher Summary It is unfeasible and unnecessary to coerce the complex biological events contributing to the origin of resistance into a single theory. Experimental evidence suggests that a few models define most examples of resistance development, particularly if the models are so combined as to provide either genotypic or phenotypic alterations ...
V, BRYSON, W, SZYBALSKI
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Publisher Summary It is unfeasible and unnecessary to coerce the complex biological events contributing to the origin of resistance into a single theory. Experimental evidence suggests that a few models define most examples of resistance development, particularly if the models are so combined as to provide either genotypic or phenotypic alterations ...
V, BRYSON, W, SZYBALSKI
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Microbial and viral drug resistance mechanisms
Trends in Microbiology, 2002Microorganisms and viruses have developed numerous resistance mechanisms that enable them to evade the effect of antimicrobials and antivirals. As a result, many have become resistant to almost every available means of treatment. This problem, although not new, is becoming increasingly acute and it is now clear that a fundamental understanding of the ...
Kenneth S, McKeegan +2 more
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Biocides, drug resistance and microbial evolution
Current Opinion in Microbiology, 2001Antimicrobial biocides are widely used in critical human health situations in which rigorous infection control is needed. Increasingly, biocidal agents are being marketed for home use, although there is little evidence that they significantly improve home hygiene. Biocide resistance mechanisms share many themes with antibiotic resistance mechanisms.
D G, White, P F, McDermott
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JAMA: The Journal of the American Medical Association, 1997
The stated intention of Microbial Drug Resistance is to be "an international journal that provides a multi-disciplinary forum for peer reviewed original papers as well as topical reviews and special reports." It focuses primarily upon "the emergence and spread of antibiotic-resistant microbial pathogens and resistance genes, and the challenges they ...
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The stated intention of Microbial Drug Resistance is to be "an international journal that provides a multi-disciplinary forum for peer reviewed original papers as well as topical reviews and special reports." It focuses primarily upon "the emergence and spread of antibiotic-resistant microbial pathogens and resistance genes, and the challenges they ...
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Microbial resistance to drug therapy: A review
American Journal of Infection Control, 1997Microbial resistance to the antimicrobials in standard use is becoming more prevalent. A historical perspective frames further discussion. Bacterial resistance is most common, but resistance has been identified in fungi, viruses, and parasites. Resistance is a complex phenomenon that involves the microorganism, the environment, and the patient ...
F L, Cohen, D, Tartasky
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Microbial Development of Drug Resistance: Mechanisms and Clinical Significance
CRC Critical Reviews in Clinical Laboratory Sciences, 1975Bacteria have demonstrated a disconcerting ability to develop resistance to antimicrobial agents nearly as quickly as new compounds become available. During the past two decades the molecular bases of several types of resistance have been elucidated.
Ruth M. Lawrence +2 more
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Exploring Microbial Nanotoxicity Against Drug Resistance in Bacteria
2021The growing threat of antimicrobial resistance on human health urgently calls for the need to look for novel solutions to mitigate the grave effect of this global problem and save thousands of lives each year. Nanotechnology is an emerging area that is expected to be able to have solutions toward containing the rise and spread of multidrug-resistant ...
Rajeshwari Sinha +2 more
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The Design of New Drugs That Resist Microbial Inactivation
Clinical Infectious Diseases, 1979Several possible strategems for overcoming the development of bacterial resistance are discussed. The design of new drugs that resist microbial inactivation is reviewed, with particular emphasis on the aminoglycoside and beta-lactam antibiotics. Examples of alteration of the inactivation site, decreased enzyme affinity, steric hindrance of enzymic ...
B G, Christensen +2 more
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