Results 271 to 280 of about 692,751 (314)
Some of the next articles are maybe not open access.
Microbial resistance to drug therapy: A review
American Journal of Infection Control, 1997Microbial resistance to the antimicrobials in standard use is becoming more prevalent. A historical perspective frames further discussion. Bacterial resistance is most common, but resistance has been identified in fungi, viruses, and parasites. Resistance is a complex phenomenon that involves the microorganism, the environment, and the patient ...
Felissa L. Cohen, Donna Tartasky
openaire +3 more sources
1955
Publisher Summary It is unfeasible and unnecessary to coerce the complex biological events contributing to the origin of resistance into a single theory. Experimental evidence suggests that a few models define most examples of resistance development, particularly if the models are so combined as to provide either genotypic or phenotypic alterations ...
Vernon Bryson, Waclaw Szybalski
openaire +3 more sources
Publisher Summary It is unfeasible and unnecessary to coerce the complex biological events contributing to the origin of resistance into a single theory. Experimental evidence suggests that a few models define most examples of resistance development, particularly if the models are so combined as to provide either genotypic or phenotypic alterations ...
Vernon Bryson, Waclaw Szybalski
openaire +3 more sources
The Design of New Drugs That Resist Microbial Inactivation
Clinical Infectious Diseases, 1979Several possible strategems for overcoming the development of bacterial resistance are discussed. The design of new drugs that resist microbial inactivation is reviewed, with particular emphasis on the aminoglycoside and beta-lactam antibiotics. Examples of alteration of the inactivation site, decreased enzyme affinity, steric hindrance of enzymic ...
L. D. Cama +2 more
openaire +3 more sources
Microbial Drug Resistance, 2020
Objective: To analyze the drug resistance data of carbapenem-resistant Klebsiella pneumoniae (CRKP) collected in 19 tertiary hospitals in the China Antimicrobial Resistance Surveillance Trial Program from 2007 to 2018.
Lei Gao, Y. Lv, Yun Li
semanticscholar +1 more source
Objective: To analyze the drug resistance data of carbapenem-resistant Klebsiella pneumoniae (CRKP) collected in 19 tertiary hospitals in the China Antimicrobial Resistance Surveillance Trial Program from 2007 to 2018.
Lei Gao, Y. Lv, Yun Li
semanticscholar +1 more source
1989
Most often when the subject of antimicrobial resistance is discussed, the organizational emphasis is on individual antimicrobial agents or groups of agents. Thus we tend to see discussion of resistance to f3-lactams, tetracyclines, amino glycosides etc.
L. E. Bryan, A. Böck
openaire +2 more sources
Most often when the subject of antimicrobial resistance is discussed, the organizational emphasis is on individual antimicrobial agents or groups of agents. Thus we tend to see discussion of resistance to f3-lactams, tetracyclines, amino glycosides etc.
L. E. Bryan, A. Böck
openaire +2 more sources
Microbial Development of Drug Resistance: Mechanisms and Clinical Significance
CRC Critical Reviews in Clinical Laboratory Sciences, 1975Bacteria have demonstrated a disconcerting ability to develop resistance to antimicrobial agents nearly as quickly as new compounds become available. During the past two decades the molecular bases of several types of resistance have been elucidated.
Ruth M. Lawrence +2 more
openaire +3 more sources
Repositioning of non-antibiotic drugs as an alternative to microbial resistance: a systematic review
International Journal of Antimicrobial Agents, 2021The global spread of microbial resistance coupled with high costs and slow pace in the discovery of a new antibiotic have made drug repositioning an attractive and promising alternative in the treatment of infections caused by multidrug resistant (MDR) microorganisms. The reuse involves the production of compounds with lower costs and development time,
Vitória S. Foletto +4 more
openaire +3 more sources
Microbial Pathogenesis and Antimicrobial Drug Resistance
2020Antimicrobial drug resistance has become a serious threat and it caused the death of 700,000 individuals in 2016. Gram-negative bacteria such as Acinetobacter, Pseudomonas, Enterobacter spp. Enterococcus faecium, Staphylococcus aureus, and Klebsiella pneumoniae are insensitive to antibiotics. E. faecium, S. aureus, K.
openaire +2 more sources
Exploring Microbial Nanotoxicity Against Drug Resistance in Bacteria
2021The growing threat of antimicrobial resistance on human health urgently calls for the need to look for novel solutions to mitigate the grave effect of this global problem and save thousands of lives each year. Nanotechnology is an emerging area that is expected to be able to have solutions toward containing the rise and spread of multidrug-resistant ...
Rajeshwari Sinha +2 more
openaire +2 more sources
Anti‐Microbial Drug Resistance: A Human Disaster in the Making
World Medical & Health Policy, 2011AbstractAnti‐microbial drug resistance (AMR or AMDR) is a complex multi‐dimensional and systemic failure in health education, social behavior, health care legislation and/or policies and practices. AMDR is a life threatening infection extending beyond national boundaries.
Thomas Zimmerman +3 more
openaire +2 more sources