Results 91 to 100 of about 9,006,960 (303)

Global burden of bacterial antimicrobial resistance 1990-2021: a systematic analysis with forecasts to 2050 [PDF]

Background: Antimicrobial resistance (AMR) poses an important global health challenge in the 21st century. A previous study has quantified the global and regional burden of AMR for 2019, followed with additional publications that provided more detailed ...
GBD, 2021 Antimicrobial Resistance Collaborators, GBD 2021 Antimicrobial Resistance Collaborators   +1 more
core   +1 more source

Negligible risk of inducing resistance in Mycobacterium tuberculosis with single-dose rifampicin as post-exposure prophylaxis for leprosy [PDF]

, 2016
Post-exposure prophylaxis (PEP) for leprosy is administered as one single dose of rifampicin (SDR) to the contacts of newly diagnosed leprosy patients. SDR reduces the risk of developing leprosy among contacts by around 60 % in the first 2-3 years after ...
Richard Anthony, Steinmann, P. (Peter), Mieras, Liesbeth, Bratschi, M W, Jan Hendrik Richardus, Kasang, C. (Christa), Arielle Cavaliero, Mieras, L. (Liesbeth), Lee Reichman, Jacques van den Broek, Cavaliero, A. (Arielle), Christa Kasang, Yew, W.W. (Wing Wai), Anthony, R, van Brakel, Wim, Reichman, L, Emmanuelle Cambau, Anthony, Richard, Steinmann, Peter, Perera, G, Saunderson, P. (Paul), Saunderson, Paul, Cavaliero, Arielle, Saunderson, P, Richardus, Jan hendrik; id_orcid, Kasang, Christa, van den Broek, Jacques, Kasang, C, Richardus, J.H. (Jan Hendrik), Cavaliero, A, Cambau, E. (Emmanuelle), Peter Steinmann, Anthony, R. (Richard), Yew, W W, Reichman, L. (Lee), Mieras, L, Yew, Wing Wai, Perera, G. (Geethal), Richardus, Jan Hendrik, Wim van Brakel, Brakel, W.H. (Wim) van, Bratschi, M.W. (Martin W.), Paul Saunderson, van Brakel, W, Cambau, E, Reichman, Lee, van den Broek, J, Bratschi, Martin W., Steinmann, P, Cambau, Emmanuelle, Geethal Perera, Wing Wai Yew, van den Broek, J. (Jacques), Perera, Geethal, Liesbeth Mieras, Martin W. Bratschi   +55 more
core   +2 more sources

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Pharmacological modulation and manipulation of cancer drug resistance [PDF]

, 2010
The aim of this project was to investigate pharmacological methods of overcoming resistance in cancer. Novel compounds, targeted therapies and non-steroidal anti-inflammatory drugs (NSAIDs) were examined for their potential to modulate and manipulate ...
Devery, Aoife
core   +2 more sources

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Bacterial distribution and drug resistance patterns of urinary tract infection in tuberculosis patients: a 5-year retrospective study

Frontiers in Microbiology
ObjectiveTo investigate the bacterial distribution and drug resistance profile of urinary tract infections (UTIs) in tuberculosis patients, and to provide evidence-based support for the rational clinical use of antimicrobial agents in this specific ...
Jian Shui, Aichun Tan, Jianhua Pan, Guomin Shi   +3 more
doaj   +1 more source

Comparative Analysis of Two Consecutive Genome Sequencing Results of Enterococcus Faecium Strain Entfacye [PDF]

Archives of Razi Institute
Introduction: The overuse of antimicrobials in healthcare has driven the emergence, persistence, and rapid spread of antimicrobial-resistant pathogens.
Maryam Yazdanizad, Ali Akbar Saboor Yaraghi, Golshid Javdani Shahedin, Mahla Asadian, Ramin Mazaheri Nezhad Fard   +4 more
doaj   +1 more source

Molecular monitoring of HIV-1 drug resistance in Ifakara HIV-1 Cohort, Tanzania [PDF]

, 2013
HIV-1 resistance is one of the problems affecting success of antiretroviral therapy programmes worldwide. Many studies on efficacy of ART programmes, specifically on drug resistance, have been conducted in developed countries but not in developing ...
Masimba, Pax Jessey
core   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source