Results 71 to 80 of about 861,905 (315)

Repair of DNA interstrand crosslinks as a mechanism of clinical resistance to melphalan in multiple myeloma

, 2002
Melphalan is widely used as a preparative agent in patients with multiple myeloma (MM) undergoing autologous stem cell transplantation (SCT). Although disease relapse is the major cause of death after a melphalan-conditioned autograft, the mechanism ...
Mahendra, P, Hochhauser, D, Hockhauser, D, Spanswick, VJ, Shankaranarayana, P, Mahendra, Premini, Hughes, RG, Craddock, Charles; id_orcid, Craddock, C, Sekhar, M, Hartley, JA, Spanswick, V   +11 more
core   +1 more source

Prevalence, Trend, and Risk Factors of Antibiotic Resistance of Klebsiella Pneumoniae in the Center of Iran During the COVID-19 Pandemic [PDF]

Epidemiology and Health System Journal
Background and aims: The emergence and spread of bacterial strains resistant to multiple antimicrobials have made the treatment of these infections increasingly challenging.
Maryam Kazemi, Mohammad Hasan Lotfi, Hengameh Zandi, Moslem Taheri Soodejani   +3 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

EXPERIENCE OF USING THE TB DRUG OF PERCHLOZON IN TUBERCULOSIS PATIENTS WITH MULTIPLE DRUG RESISTANCE IN BURYATIA REPUBLIC

Туберкулез и болезни лёгких, 2015
Lately the main TB epidemiological rates are becoming stable in Buryatia Republic. In 2013-2014 the e¾ciency of use of perchlozon was studied within integral treatment of pulmonary tuberculosis patients with multiple and extensive drug resistance (MDR ...
S. V. Nikolaeva
doaj  

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Characterisation and modulation of drug resistance in lung cancer cell lines [PDF]

, 2010
Chemotherapy drug resistance is a major obstacle in the treatment of cancer. It can result from an increase in levels of cellular drug efflux pumps such as P-glycoprotein (P-gp).
Dunne, Gráinne
core  

Antibiotic Resistance of Vibrio cholerae Isolates from Kashan, Iran

International Archives of Health Sciences, 2016
Aims: Cholera is an acute diarrheal disease that can lead to severe dehydration and death. Antibiotic resistance is a big challenge in infective disease like Cholera.
Afzali H.MD,, Momen-Heravi M.* MD,, Razzaghi R. MD   +2 more
doaj  

In Vitro Efficacy of Imipenem/Relebactam Against Imipenem Resistant Gram-Negative Strains Isolated from a Tertiary Care Hospital

Pakistan Armed Forces Medical Journal
Objective: To determine in vitro efficacy of Imipenem/Relebactam against multi-drug resistant strains. Study Design: Cross-sectional study. Place and Duration of Study: Department of Microbiology, Fauji Foundation Hospital (FFH) Rawalpindi, Pakistan
Saima Ishtiaq, Sonia Tahir, Muhammad Waqas Abbas, Haider Ali, Saima Syed, Fatima Kareem   +5 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source