Results 61 to 70 of about 861,905 (315)

Drug susceptibility of M. tuberculosis in tuberculosis patients from various population groups in Khanty-Mansiyskiy Autonomous Region

Туберкулез и болезни лёгких, 2015
The study included 287 cultures of tuberculous mycobacteria received from specimens of patients from Khanty-Mansiysky TB Dispensary in 2011-2012. Patients from Khanty-Mansiysky TB Dispensary have a fairly high rate (24.0%) of co-infection of TB and HIV ...
Yu. V. Reshetnikova, S. N. Аndreevskaya, E. E. Larionova   +2 more
doaj  

Understanding and targeting resistance mechanisms in cancer

MedComm, 2023
Resistance to cancer therapies has been a commonly observed phenomenon in clinical practice, which is one of the major causes of treatment failure and poor patient survival. The reduced responsiveness of cancer cells is a multifaceted phenomenon that can
Zi‐Ning Lei, Qin Tian, Qiu‐Xu Teng, John N. D. Wurpel, Leli Zeng, Yihang Pan, Zhe‐Sheng Chen   +6 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

EXPERIENCE OF USING BEDAQUILINE IN THE TREATMENT OF PULMONARY TUBERCULOSIS PATIENTS WITH MULTIPLE ANDEXTENSIVE DRUG RESISTANCE

Туберкулез и болезни лёгких, 2018
The article presents the evaluation of safety and efficiency of chemotherapy regimens including the new anti-tuberculosis agent of bedaquiline in 21 pulmonary tuberculosis patients with multiple and extensive drug resistance who were treated in Stavropol
N. M. Konovаlovа, V. S. Odinets, T. I. Vаsilenko, T. A. Zаdremаylovа   +3 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Post-translational modifications in drug resistance

Resistance to antitumor drugs, antimicrobial drugs, and antiviral drugs severely limits treatment effectiveness and cure rate of diseases. Protein post-translational modifications (PTMs) represented by glycosylation, ubiquitination, SUMOylation ...
Zhang, Cheng, Miao, Chenggui, Zhou, Xinyue, Chen, Zhe Sheng, Huang, Yurong, Wang, Bing, Song, Yingqiu, Feng, Yibin, Wu, Peng, Wang, Xiao   +9 more
core   +1 more source

ANALYSIS OF THE PATIENTS REFERRED FOR TREATMENT TO NOVOSIBIRSK TUBERCULOSIS RESEARCH INSTITUTE FROM THE AREAS SUPERVISED BY THIS INSTITUTE. CHANGES IN CHEMOTHERAPY EFFICIENCY AFTER INTRODUCTION OF THE UPDATED TREATMENT REGIMENS AND MICROBIOLOGICAL DIAGNOSTICS

Туберкулез и болезни лёгких, 2017
In 2015 the implementation of Edicts no. 951 by the Russian Ministry of Health On Guidelines on Improvement of Respiratory Tuberculosis Treatment and Diagnostics was started.Goal of the study: to analyze the characteristics of tuberculosis patients ...
E. P. Myshkova, E. M. Zhukova, T. A. Reykhrud   +2 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Significant geographical differences in prevalence of mutations associated with Plasmodium falciparum and Plasmodium vivax drug resistance in two regions from Papua New Guinea [PDF]

, 2015
Drug resistance remains a major obstacle to malaria treatment and control. It can arise and spread rapidly, and vary substantially even at sub-national level.
Jonah Iga (175169), Barnadas, Céline, Zimmerman, Peter A., Timinao, Lincoln, Koepfli, Cristian, Peter Siba (112258), Sarah Javati (464175), John Reeder (3400391), Kiniboro, Benson, Ivo Mueller (46609), Senn, Nicolas, Javati, Sarah, Iga, Jonah, Malau, Elisheba, Rare, Lawrence, Mueller, Ivo, Elisheba Malau (3518690), Benson Kiniboro (191309), Lincoln Timinao (423264), CĂŠline Barnadas (3506528), Siba, Peter, Timothy Davis (268628), Harin Karunajeewa (336719), Davis, Timothy M., Leanne Robinson (175144), Reeder, John C., Nicolas Senn (137902), Peter Zimmerman (34037), Robinson, Leanne J., Siba, Peter M., Karunajeewa, Harin, Cristian Koepfli (191306), Lawrence Rare (377507)   +32 more
core   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source