Overcoming multiple drug resistance mechanisms in medulloblastoma. [PDF]
Acta Neuropathol Commun, 2014 Introduction: Medulloblastoma (MB) is the most common malignant paediatric brain tumour. Recurrence and progression of disease occurs in 15-20% of standard risk and 30-40% of high risk patients.
Othman RT +8 more
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The complex relationship between multiple drug resistance and the tumor pH gradient: a review. [PDF]
Cancer Drug Resist, 2022 Multiple drug resistance (MDR) is the tumor’s way of escaping the cytotoxic effects of various unrelated chemotherapeutic drugs. It can be either innate or acquired.
Koltai T.
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Multiple drug resistance in hookworms infecting greyhound dogs in the USA. [PDF]
Int J Parasitol Drugs Drug Resist, 2021 The hookworm Ancylostoma caninum is the most prevalent nematode parasite of dogs. Recently, we confirmed multiple-drug resistance (MDR) in several A. caninum isolates to all anthelmintic drug classes approved for the treatment of hookworms in dogs in the
Jimenez Castro PD +9 more
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Tyrosol induces multiple drug resistance in yeast Saccharomyces cerevisiae [PDF]
Frontiers in Microbiology, 2023 In yeast, multiple (pleiotropic) drug resistance (MDR) transporters efflux xenobiotics from the cytoplasm to the environment. Additionally, upon the accumulation of xenobiotics in the cells, MDR genes are induced.
Elizaveta O. Noskova +5 more
doaj +2 more sources
Multiple drug resistance in the canine hookworm Ancylostoma caninum: an emerging threat? [PDF]
Parasit Vectors, 2019 The canine hookworm, Ancylostoma caninum is the most prevalent and important intestinal nematode parasite of dogs in the USA. Hookworms are typically well controlled by treatment with all commonly used anthelmintics that are approved for this use in dogs.
Jimenez Castro PD +5 more
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Selinexor Overcomes Hypoxia-Induced Drug Resistance in Multiple Myeloma [PDF]
Translational Oncology, 2017 Increased levels of the nuclear export protein, exportin 1 (XPO1), were demonstrated in multiple myeloma (MM) patients. Targeting XPO1 with selinexor (the selective inhibitor of nuclear export; SINE compound KPT-330) demonstrates broad antitumor activity
Barbara Muz +4 more
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Understanding the evolution of multiple drug resistance in structured populations [PDF]
eLife, 2021 The evolution of multidrug resistance (MDR) is a pressing public health concern. Yet many aspects, such as the role played by population structure, remain poorly understood.
David V McLeod, Sylvain Gandon
doaj +2 more sources
Multiple drug resistance and biocide resistance in Escherichia coli environmental isolates from hospital and household settings. [PDF]
Antimicrob Resist Infect Control, 2018 BackgroundAntibiotic resistance of environmental Escherichia coli in hospitals could be increased due to extensive use of biocides resulting in serious infections.
Ghanem B, Haddadin RN.
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Multiple Mechanisms Synergistically Induce Pseudomonas Aeruginosa Multiple Drug Resistance
Microbiology Research, 2023 The aim of this study was to understand the molecular epidemiological characteristics and drug resistance mechanism of carbapenem-resistant Pseudomonas aeruginosa (CRPA) and to provide a theoretical basis for the prevention and treatment of CRPA ...
Pei Dai +6 more
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Development, Maintenance, and Reversal of Multiple Drug Resistance: At the Crossroads of TFPI1, ABC Transporters, and HIF1. [PDF]
Cancers (Basel), 2015 Early detection and improved therapies for many cancers are enhancing survival rates. Although many cytotoxic therapies are approved for aggressive or metastatic cancer; response rates are low and acquisition of de novo resistance is virtually universal.
Arnason T, Harkness T.
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