Results 11 to 20 of about 882,168 (215)

Selinexor Overcomes Hypoxia-Induced Drug Resistance in Multiple Myeloma

Translational Oncology, 2017
Increased levels of the nuclear export protein, exportin 1 (XPO1), were demonstrated in multiple myeloma (MM) patients. Targeting XPO1 with selinexor (the selective inhibitor of nuclear export; SINE compound KPT-330) demonstrates broad antitumor activity
Barbara Muz, Feda Azab, Pilar de la Puente, Yosef Landesman, Abdel Kareem Azab   +4 more
doaj   +1 more source

Clinical Resistance of Helicobacter pylori and Its Trend: A 10-year Data Analysis at Peking University People's Hospital

Xiehe Yixue Zazhi, 2023
Objective  To study the resistance of Helicobacter pylori(Hp) isolated from Peking University People's Hospital to commonly used antibiotics, in order to provide basis for clinical rational drug use.
ZHANG Feifei, WANG Qi, LI Shuguang, WANG Zhanwei, LIANG Xinyue, MENG Han, YANG Shuo, WANG Hui   +7 more
doaj   +1 more source

Epigenetic Regulation of Antifungal Drug Resistance

Journal of Fungi, 2022
In medical mycology, epigenetic mechanisms are emerging as key regulators of multiple aspects of fungal biology ranging from development, phenotypic and morphological plasticity to antifungal drug resistance.
Sandip Patra, Mayur Raney, Aditi Pareek, Rupinder Kaur   +3 more
doaj   +1 more source

Efficacy and safety of bedaquiline in treatment regimens in patients TB/HV co-infection in the Udmurt Republic

Туберкулез и болезни лёгких, 2023
The objective: to evaluate the efficacy and safety of bedaquiline in new chemotherapy regimens in HIV-positive tuberculosis patients.Subjects and Methods.
O. E. Russkikh, E. V. Savintseva, D. A. Kudlay, Zh. I. Krivosheeva   +3 more
doaj   +1 more source

m6A Modification in Non-Coding RNA: The Role in Cancer Drug Resistance

Frontiers in Oncology, 2021
Cancer drug resistance has always been a major difficulty in cancer therapy. In the face of drug pressure, resistant cancer cells show complex molecular mechanisms including epigenetic changes to maintain survival. Studies prove that cancer cells exhibit
Chen Chen, Chen Chen, Yuying Guo, Yaxin Guo, Yaxin Guo, Xiaoke Wu, Chaohua Si, Yanxin Xu, Qiaozhen Kang, Zhenqiang Sun   +9 more
doaj   +1 more source

Left-Sided Endocarditis Associated with Multi-Drug Resistance Acinetobacter Lwoffii [PDF]

Journal of Tehran University Heart Center, 2009
Acinetobacter lwoffii, an important nosocomial pathogen, is a gram-negative aerobic bacillus that is a component of the normal flora on the skin, oropharynx, and perineum of about 20-25% of healthy individuals.
Naghmeh Moshtaghi, Abbasali Karimi, Maryam Sotoudeh Anvari, Mohammad Ali Boroumand, Hossein Ahmadi   +4 more
doaj   +2 more sources

The role of non‐coding RNAs in drug resistance of oral squamous cell carcinoma and therapeutic potential

Cancer Communications, 2021
Oral squamous cell carcinoma (OSCC), the eighth most prevalent cancer in the world, arises from the interaction of multiple factors including tobacco, alcohol consumption, and betel quid.
Xiang Meng, Qiu‐Yue Lou, Wen‐Ying Yang, Yue‐Rong Wang, Ran Chen, Lu Wang, Tao Xu, Lei Zhang   +7 more
doaj   +1 more source

TUBERCULOSIS WITH MULTIDRUG-RESISTANT AND EXTENSIVELY DRUG-RESISTANT OF MICOBACTERIUM TUBERCULOSIS IN THE RUSSIAN FEDERATION

Паёми Сино, 2018
Objective: To assess the epidemic situation in the Russian Federation on tuberculosis with multidrug-resistant and extensively drug-resistant (MDR, XDR) of the pathogen and the effectiveness of its treatment.
A.E. ERGESHOV, V.V. PUNGA, L.I. RUSAKOVA, S.A. STERLIKOV, M.A. YAKIMOVA, Т.V. IZMAYLOVA   +5 more
doaj   +1 more source

Intra-Vesical Colistin for Pseudomonas aeruginosa Urinary Tract Infections

European Journal of Case Reports in Internal Medicine, 2019
The numbers of multiple drug-resistant Gram-negative bacterial infections are rising worldwide. The threat is increased by the lack of new antibiotics, so clinicians are turning to older drugs previously abandoned due to their recognized toxicity, such ...
Rui Encarnado Assis, Inês Coelho, André Real, Luís França, Ana Araújo, Tiago Pereira, Nuno Catorze   +6 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source