Adaptive HIV-1 evolutionary trajectories are constrained by protein stability [PDF]
, 2017 Despite the use of combination antiretroviral drugs for the treatment of HIV-1 infection, the emergence of drug resistance remains a problem. Resistance may be conferred either by a single mutation or a concerted set of mutations.
Kandathil, Shaun M. +3 more
core +2 more sources
miR-874 regulates multiple-drug resistance in gastric cancer by targeting ATG16L1.
International Journal of Oncology, 2018 Chemotherapy is an important treatment option for gastric cancer (GC); however, chemotherapy usually fails due to drug resistance, particularly multidrug resistance (MDR). In our previous studies, microRNA (miR)‑874 was demonstrated to serve an important
Haijin Huang +4 more
semanticscholar +1 more source
Molecular Dynamics Studies on HIV-1 Protease: Drug Resistance and Folding Pathways [PDF]
, 2001 Drug resistance to HIV-1 Protease involves accumulation of multiple mutations in the protein. Here we investigate the role of these mutations by using molecular dynamics simulations which exploit the influence of the native-state topology in the folding ...
Carloni, Paolo +3 more
core +2 more sources
Multiple Myeloma: Available Therapies and Causes of Drug Resistance
Cancers, 2020 Multiple myeloma (MM) is the second most common blood cancer. Treatments for MM include corticosteroids, alkylating agents, anthracyclines, proteasome inhibitors, immunomodulatory drugs, histone deacetylase inhibitors and monoclonal antibodies.
Vanessa Pinto +5 more
semanticscholar +1 more source
Epigenetic Regulation of Antifungal Drug Resistance
Journal of Fungi, 2022 In medical mycology, epigenetic mechanisms are emerging as key regulators of multiple aspects of fungal biology ranging from development, phenotypic and morphological plasticity to antifungal drug resistance.
Sandip Patra +3 more
doaj +1 more source
m6A Modification in Non-Coding RNA: The Role in Cancer Drug Resistance
Frontiers in Oncology, 2021 Cancer drug resistance has always been a major difficulty in cancer therapy. In the face of drug pressure, resistant cancer cells show complex molecular mechanisms including epigenetic changes to maintain survival. Studies prove that cancer cells exhibit
Chen Chen +9 more
doaj +1 more source
Draft Genome Sequences of Antibiotic-Resistant Commensal Escherichia coli [PDF]
, 2014 Antimicrobial resistance is a significant public health issue. We report here the draft genome sequences of three drug-resistant strains of commensal Escherichia coli isolated from a single healthy college student.
Garrett, Meghan +2 more
core +2 more sources
Antiretroviral drug resistance mutations in naïve and experienced patients in Shiraz, Iran, 2014 [PDF]
, 2016 Resistance to antiretroviral agents is a significant concern in the clinical management of HIV-infected individuals, particularly in areas of the world where treatment options are limited.
Aghasadeghi, M.R. +6 more
core +1 more source
Туберкулез и болезни лёгких, 2023 The objective: to evaluate the efficacy and safety of bedaquiline in new chemotherapy regimens in HIV-positive tuberculosis patients.Subjects and Methods.
O. E. Russkikh +3 more
doaj +1 more source
Rapid microarray-based method for monitoring of all currently known single-nucleotide polymorphisms associated with parasite resistance to antimalaria drugs. [PDF]
, 2007 Parasite drug resistance is partly conferred by single-nucleotide polymorphisms (SNPs), and monitoring them has been proposed as an alternative to monitoring drug resistance.
Beck, Hans-Peter +13 more
core +2 more sources