Results 21 to 30 of about 843,571 (261)
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Sickle cell disease (SCD) is a chronic, inherited hemoglobinopathy that requires frequent hospitalization for disease‐related complications. Canadian data on inpatient care is limited. This study compared caregiver‐reported hospital experiences of children with SCD to those with cystic fibrosis (CF), a chronic, autosomal recessive ...
Hailey M. Zwicker +11 more
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Understanding and targeting resistance mechanisms in cancer
MedComm, 2023 Resistance to cancer therapies has been a commonly observed phenomenon in clinical practice, which is one of the major causes of treatment failure and poor patient survival. The reduced responsiveness of cancer cells is a multifaceted phenomenon that can
Zi‐Ning Lei +6 more
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FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
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Туберкулез и болезни лёгких, 2018 The article presents the evaluation of safety and efficiency of chemotherapy regimens including the new anti-tuberculosis agent of bedaquiline in 21 pulmonary tuberculosis patients with multiple and extensive drug resistance who were treated in Stavropol
N. M. Konovаlovа +3 more
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Туберкулез и болезни лёгких, 2022 The objective: to identify and systematize social and demographic risk factors for the development and spread of multiple drug resistant tuberculosis (MDR TB) in the Russian Federation (RF) by means of a systematic review of existing publications ...
I. A. Bykov
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Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
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Туберкулез и болезни лёгких, 2017 In 2015 the implementation of Edicts no. 951 by the Russian Ministry of Health On Guidelines on Improvement of Respiratory Tuberculosis Treatment and Diagnostics was started.Goal of the study: to analyze the characteristics of tuberculosis patients ...
E. P. Myshkova +2 more
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Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
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Lijecnicki vjesnik, 1994 The multidrug-resistance (MDR) phenotype expressed in mammalian cell lines is complex. A cell selected with a single agent can acquire cross-resistance to a remarkably wide range of compounds which have no structural or functional similarities. The basis for cross-resistance seems to be a decreased net cellular accumulation of the drugs involved, and ...
C R, Leveille, A S, Moore
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FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
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